Patents Assigned to The Regents of the University of
  • Molecules with effects on cellular development and function
    Publication number: 20090202471
    Abstract: This invention relates to methods to stabilize and/or improve the function of parenchymal cells. Also provided are systems of co-cultures of hepatocyte-stabilizing non-parenchymal cells used in bioreactor microenvironments to identify hepatic stabilizing factors by gene-expression profiling.
    Type: Application
    Filed: August 4, 2005
    Publication date: August 13, 2009
    Applicant: The Regents of the University of California
    Inventors: Salman R. Khetani, Sangeeta N. Bhatia
  • METHOD FOR TREATING CANCER USING ANTI-WNT2 MONOCLONAL ANTIBODIES AND siRNA
    Publication number: 20090202539
    Abstract: This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor.
    Type: Application
    Filed: January 30, 2009
    Publication date: August 13, 2009
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Liang You, Biao He, Zhidong Xu, David M. Jablons
  • METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS
    Publication number: 20090203077
    Abstract: Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the cell under conditions for producing commercially viable Factor VIII protein. Also provided are nucleic acid molecules which encode a Factor VIII protein operably linked to a Chinese hamster elongation factor 1-? (CHEF1) promoter, which may be used in the methods provided herein.
    Type: Application
    Filed: October 15, 2008
    Publication date: August 13, 2009
    Applicant: The Regents of the University of Michigan
    Inventors: Randal J. Kaufman, Steven W. Pipe, Michael Griffith
  • POLARIZED LIGHT-EMITTING FILM AND METHOD FOR PRODUCING THE SAME
    Publication number: 20090202712
    Abstract: A polarized light-emitting layer that comprises a porous silica film formed on a substrate and a conjugated polymer held in the uniaxially oriented, tubular mesopores in the porous silica film. The film can emit fluorescence polarized in a direction parallel to the alignment direction of the mesopores. The film can act as a lasing layer with a low excitation threshold.
    Type: Application
    Filed: March 12, 2009
    Publication date: August 13, 2009
    Applicants: CANON KABUSHIKI KAISHA, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Hirokatsu Miyata, Sarah H. Tolbert, William C Molenkamp, Benjamin Joel Schwartz, Ignacio Bartolome Martini
  • Atomic magnetic gradiometer for room temperature high sensitivity magnetic field detection
    Patent number: 7573264
    Abstract: A laser-based atomic magnetometer (LBAM) apparatus measures magnetic fields, comprising: a plurality of polarization detector cells to detect magnetic fields; a laser source optically coupled to the polarization detector cells; and a signal detector that measures the laser source after being coupled to the polarization detector cells, which may be alkali cells. A single polarization cell may be used for nuclear magnetic resonance (NMR) by prepolarizing the nuclear spins of an analyte, encoding spectroscopic and/or spatial information, and detecting NMR signals from the analyte with a laser-based atomic magnetometer to form NMR spectra and/or magnetic resonance images (MRI). There is no need of a magnetic field or cryogenics in the detection step, as it is detected through the LBAM.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: August 11, 2009
    Assignee: The Regents of the University of California
    Inventors: Shoujun Xu, Thomas L. Lowery, Dmitry Budker, Valeriy V. Yashchuk, David E. Wemmer, Alexander Pines
  • System and method of string matching for uniform data classification
    Patent number: 7574742
    Abstract: A system and method comprising providing a plurality of signature strings, inputting a plurality of strings, separating the signature strings into a plurality of signature groups, respectively detecting common features for the signature strings for each of the signature groups and the input strings, comparing the detected common features for each of the signature groups with those of the input strings, and matching the input strings and the signature groups if the detected common features for the signature groups match those of the input strings. In one aspect, the string matching further comprises matching the input strings with the signature strings for those of the signature groups having common features that match the common features of the input strings. In another aspect, the common features comprise distances or gaps between characters in the input strings and the signature strings.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: August 11, 2009
    Assignees: Industrial Technology Research Institute, The Regents of the University of California
    Inventors: Tzy-Jian Yang, Kuan-Ming Lin, Shing-Hung Lee, Shyhtsun Felix Wu
  • EEG feedback controlled sound therapy for tinnitus
    Patent number: 7572234
    Abstract: An automated method for treating tinnitus by habituation through use of neurological feedback, comprising the steps of connecting a subject through a set of attached headphones to an electronic sound player that is connected to a PC workstation presenting sound examples by software to the subject who can refine them by manipulating a series of controllers on the player, making an electronic recording of the sound in a digital music format, storing the recording in the computer, transferring a copy of the electronic sound file to the subject's electronic music player, generating an EEC signature of the subject's brain activity in response to the presented sound, sound using the customized sound to stimulate the auditory system while the brain activity is recorded, wherein the computer continuously monitors for the feedback signatures and drives the sound stimuli appropriately.
    Type: Grant
    Filed: November 30, 2005
    Date of Patent: August 11, 2009
    Assignee: The Regents of the University of California
    Inventors: Erik Viirre, Jaime A. Pineda, John D. Hestenes, Andrey Vankov
  • Kidney-specific tumor vaccine directed against kidney tumor antigen G-250
    Patent number: 7572891
    Abstract: This invention provides an anti-cancer immunogenic agent(s) (e.g. vaccines) that elicit an immune response specifically directed against renal cell cancers expressing a G250 antigenic marker. Preferred immunogenic agents comprise a chimeric molecule comprising a kidney cancer specific antigen (G250) attached to a granulocyte-macrophage colony stimulating factor (GM-CSF). The agents are useful in a wide variety of treatment modalities including, but not limited to protein vaccination, DNA vaccination, and adoptive immunotherapy.
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: August 11, 2009
    Assignee: The Regents of the University of California
    Inventors: Arie Belldegrun, Cho-Lea Tso
  • Cleavable linkers for polynucleotides
    Patent number: 7572908
    Abstract: In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: August 11, 2009
    Assignees: Agilent Technologies, Inc., The Regents of the University of Colorado
    Inventors: Douglas J Dellinger, Zoltan Timar, Joel Myerson, Geraldine Dellinger, Marvin Caruthers
  • Compositions and methods relating to novel compounds and targets thereof
    Patent number: 7572788
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: August 11, 2009
    Assignee: The Regents of the University of Michigan
    Inventors: Gary D. Glick, Anthony W. Opipari
  • Selected antibody compositions for binding to aminophospholipids
    Patent number: 7572442
    Abstract: Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
    Type: Grant
    Filed: July 15, 2003
    Date of Patent: August 11, 2009
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Sophia Ran
  • Methods and compounds for polynucleotide synthesis
    Patent number: 7572907
    Abstract: Methods of forming polynucleotides are disclosed.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: August 11, 2009
    Assignees: Agilent Technologies, Inc., The Regents of the University of Colorado
    Inventors: Douglas J. Dellinger, Geraldine Dellinger, Marvin H. Caruthers, Zoltan Kupihar
  • Engineered self healing cementitious composites
    Patent number: 7572501
    Abstract: Cementitious composites engineered for self-healing, combining self-controlled tight crack width and extreme tensile ductility. Self-healing takes place automatically at cracked locations without external intervention. In the exemplary embodiment, fiber-reinforced cementitious composites with self-controlled tight crack width less than 50 ?m and tensile ductility more than 2% are prepared. Self-healing in terms of mechanical and transport properties recovery of pre-damaged (by pre-cracking) composite is revealed in a variety of environmental exposures, include wetting and drying cycles, water permeation, and chloride submersion.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: August 11, 2009
    Assignee: The Regents of the University of Michigan
    Inventors: Victor C. Li, En-Hua Yang
  • Method for fabricating vertically-offset interdigitated comb actuator device
    Patent number: 7573022
    Abstract: The present invention relates to systems and methods for fabricating microscanners. The fabrication processes employed pursuant to some embodiments are compatible with well known CMOS fabrication techniques, allowing devices for control, monitoring and/or sensing to be integrated onto a single chip. Both one- and two-dimensional microscanners are described. Applications including optical laser surgery, maskless photolithography, portable displays and large scale displays are described.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: August 11, 2009
    Assignee: The Regents of the University of California
    Inventors: Hyuck Choo, David Garmire, Richard S. Muller, James Demmel
  • Combined cancer treatment methods using selected antibodies to aminophospholipids
    Patent number: 7572448
    Abstract: Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: August 11, 2009
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Xianming Huang, Sophia Ran
  • VERTICAL OUTGASSING CHANNELS
    Publication number: 20090194787
    Abstract: InP epitaxial material is directly bonded onto a Silicon-On-Insulator (SOI) wafer having Vertical Outgassing Channels (VOCs) between the bonding surface and the insulator (buried oxide, or BOX) layer. H2O and other molecules near the bonding surface migrate to the closest VOC and are quenched in the buried oxide (BOX) layer quickly by combining with bridging oxygen ions and forming pairs of stable nonbridging hydroxyl groups (Si—OH). Various sizes and spacings of channels are envisioned for various devices.
    Type: Application
    Filed: January 14, 2009
    Publication date: August 6, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Di Liang
  • ENHANCEMENT OF OPTICAL POLARIZATION OF NITRIDE LIGHT-EMITTING DIODES BY INCREASED INDIUM INCORPORATION
    Publication number: 20090194761
    Abstract: An increase in the Indium (In) content in light-emitting layers of light-emitting diode (LED) structures prepared on nonpolar III-nitride substrates result in higher polarization ratios for light emission than LED structures containing lesser In content. Polarization ratios should be higher than 0.7 at wavelengths longer than 470 nm.
    Type: Application
    Filed: February 2, 2009
    Publication date: August 6, 2009
    Applicant: The Regents of the University of California
    Inventors: Hisashi Masui, Hisashi Yamada, Kenji Iso, James S. Speck, Shuji Nakamura, Steven P. DenBaars
  • Ostial Stenting System
    Publication number: 20090198178
    Abstract: A method and apparatus provide techniques for stenting ostial legions and other restenosis in vessels through a stenting apparatus that includes both a guidewire and a separate marker wire. In some examples, the marker wire is threaded through a tubular body of the stenting apparatus and in other examples, the marker wire may be threaded externally through the tubular body. In both such examples, the marker wire may be aligned with a radiopaque marker of the apparatus to guide marker wire positioning.
    Type: Application
    Filed: December 24, 2008
    Publication date: August 6, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Hitinder Gurm
  • LITHOGRAPHICALLY PATTERNED NANOWIRE ELECTRODEPOSITION
    Publication number: 20090197209
    Abstract: Lithographically patterned nanowire electrodeposition (LPNE) combines attributes of photolithography with the versatility of bottom-up electrochemical synthesis. Photolithography is employed to define the position of a sacrificial nanoband electrode, preferably formed from a metal such as nickel, copper, silver, gold or the like, which is stripped using electrooxidation or a chemical etchant to advantageously recess the nanoband electrode between a substrate surface and the photoresist to form a trench defined by the substrate surface, the photoresist and the nanoband electrode. The trench acts as a “nanoform” to form an incipient nanowire during its electrodeposition. The width of the nanowire is determined by the electrodeposition duration while its height is determined by the height of the nanoband electrode.
    Type: Application
    Filed: August 21, 2007
    Publication date: August 6, 2009
    Applicant: The Regents of the University of California
    Inventors: Reginald M. Penner, Erik J. Menke, Michael A. Thompson, Chengxiang Xiang
  • BIOCIDAL FIBERS
    Publication number: 20090197084
    Abstract: The present invention provides graft biocidal N-halamine polymers. The biocidal polymers are prepared by contacting precursor graft polymers with a halogen source. The precursor graft polymers are prepared by grafting a polymer, such as a polyolefin, with a vinyl monomer under suitable conditions, for example, a reactive extrusion condition. In one embodiment, the graft polymerization is carried out in the presence of a vinyl monomer and a radical initiator. The biocidal polymers have potent antimicrobial activities against a broad spectrum of microorganisms and virus, such as E. coli and flu viruses.
    Type: Application
    Filed: March 4, 2009
    Publication date: August 6, 2009
    Applicant: The Regents of the University of California
    Inventors: Gang Sun, Mohammad Reza Badrossamay