Abstract: Mounting systems for solar panel assemblies and related methods are generally described. In some embodiments, a clamp adapter may be used to mount a conventional panel support structure of a solar panel assembly to a conventional bracket of a base assembly without the use of bolts in at least some embodiments. The clamp adapter may include a rail slot for receiving the structure, a lower flange for receiving a lower surface of a mounting lip of the bracket, and a lateral flange for receiving an upper surface of the mounting lip. The lower flange may be angled to accommodate a variety of mounting lip angles. In some embodiments, the mounting system may also include a connector configured to mechanically connect the bracket and structure.

Abstract: Disclosed herein are methods, systems, and devices for oral drug delivery. The method generally involves orally administering a drug delivery device to the subject in need of treatment and triggering iontophoresis. The drug delivery device includes one or more active agents for delivery to the subject. The method can include the step of delivering the active agent to the intestinal mucosa after iontophoresis is triggered at the site, or simultaneously as iontophoresis is applied at the site. After the active agent(s) are delivered, the drug delivery device can be released from the intestinal mucosa. The iontophoresis can be performed for a period of time and at an electrical current that is effective to improve permeability of the one or more active agents across the intestine compared to orally administering the same drug delivery device in the absence of iontophoresis.

Abstract: Systems and methods for generative adversarial networks (GANs) to remove artifacts from undersampled magnetic resonance (MR) images are described. The process of training the GAN can include providing undersampled 3D MR images to the generator model, providing the generated example and a real example to the discriminator model, applying adversarial loss, L2 loss, and structural similarity index measure loss to the generator model based on a classification output by the discriminator model, and repeating until the generator model has been trained to remove the artifacts from the undersampled 3D MR images. At runtime, the trained generator model of the GAN can be generate artifact-free images or parameter maps from undersampled MRI data of a patient.

Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.

Abstract: The present disclosure provides a high-performance integrated strain sensing device that is highly stretchable, rehealable, recyclable and reconfigurable. This device can include dynamic covalent thermoset polyimine as the substrate and encapsulation, eutectic liquid metal alloy as the strain sensing unit and interconnects, and off-the-shelf chip components for measuring and magnifying functions. The device can be attached on the knee, elbow, wrist and finger joints for strain sensing and motion monitoring, and can also be attached on the abdomen to accurately measure respiration cycles.

Abstract: Disclosed herein, inter alia, are compounds for binding STRAD pseudokinase and uses thereof.

Abstract: Disclosed are reversibly-expandable polymer-integrated crystals (PIX) materials, devices, and methods for controllably encapsulating and releasing molecular cargo. The disclosed PIX materials are engineered crystalline materials with large pores that can entrap macromolecules, such as proteins and nanoparticles. The material expands and contracts reversibly, allowing controlled encapsulation and release of guest/cargo molecules.

Abstract: Provided are methods of analyzing capped ribonucleic acids (RNAs). The methods include translocating an adapted RNA through a nanopore of a nanopore device. The adapted RNA includes an RNA region, a 5? cap, and an adapter polynucleotide attached to the 5? cap. The methods include monitoring ionic current through the nanopore during the translocating, translocating the 5? cap through the nanopore, and identifying one or more ionic current features characteristic of the 5? cap (e.g., a triphosphate linkage between the 5? cap and nucleotide N1 of the RNA region, a 5? to 5? orientation of the 5? cap and nucleotide N1 of the RNA region, and/or the like), translocating through the nanopore. Also provided are computer-readable media, computer devices, and systems that find use, e.g., in practicing the methods of the present disclosure.

Abstract: An instrument cart configured to position an instrument controller at a desired location and attitude pitch with respect to an incision location of a patient includes a base, a lift member moveable with respect to the base, a first planar translation member connected to the lift member and arcuately moveable with respect thereto, a second planar translation member connected to the first planar translation member and arcuately moveable with respect thereto, a third planar translation member connected to the second planar translation member and arcuately moveable with respect thereto, an arcuate slide base connected to the third planar translation member and moveable with respect thereto and an arcuate slide coupled to the arcuate slide base, and moveable with respect thereto; and an instrument controller coupling connected to the arcuate slide member, the instrument controller connected thereto and movable with respect thereto.

Abstract: A computer-implemented method includes receiving a raw data set representing an image of a sample, identifying a first set of extremum by analyzing the raw data set using a metric algorithm, identifying a second set of extremum by analyzing the first set of extremum, and generating, based on the second set of extremum, a reconstructed image of the sample. A phase correcting scanner includes one or more processors, one or more scanner adapted to sequentially sample an object to generate a vector of raw data representing the object in a Lissajous pattern, and memory storing instructions that, when executed by the one or more processors, cause the computing system to receive the vector of raw data, identify a first set of extremum by analyzing the raw data set using a metric algorithm, and identify a second set of extremum by analyzing the first set of extremum.

Abstract: The present disclosure relates to methods, devices, kits and systems for enhancing the efficacy and longevity of denervation procedures.

Abstract: Manufacturing a neural interface device. Forming a neural interface probe of an implantable microelectrode body. PECVD a first amorphous silicon carbide insulation layer, forming a thin film metal trace and interface pad on the first layer, the pad on a portion of the trace. PECVD a second amorphous silicon carbide insulation layer on the first layer and covering the trace and the pad. Forming an opening in the second layer to expose the pad to an ambient environment. Patterning the first and second layers to define the neural interface probe. The probe has a rectangular cuboid shape, a cross-sectional area perpendicularly transverse to a long axis length of the probe and through any perpendicularly transverse cross-section along the long axis length is less than about 50 microns. The layers are the principle material of construction of the probe.

Abstract: Provided herein are methods and materials for detecting and/or treating subject (e.g. a human) having cancer. In some embodiments, methods and materials for identifying a subject as having cancer (e.g., a localized cancer) are provided in which the presence of member(s) of two or more classes of biomarkers are detected. In some embodiments, methods and materials for identifying a subject as having cancer (e.g. a localized cancer) are provided in which the presence of member(s) of at least one class of biomarkers and the presence of aneuploidy are detected. In some embodiments, methods described herein provide increased sensitivity and/or specificity in the detection of cancer in a subject (e.g. a human).

Abstract: Methods, apparatuses, systems, and implementations for creating 3-dimensional (3D) representations exhibiting geometric and surface characteristics of brain lesions are disclosed. 2D and/or 3D MRI images of the brain may be acquired. Brain lesions and other abnormalities may be identified and isolated with each lesion serving as a region of interest (ROI). Saved ROI may be converted into stereolithography format, maximum intensity projection (MIP) images, and/or orthographic projection images. Data corresponding to these resulting 3D brain lesion images may be used to create 3D printed models of the isolated brain lesions using 3D printing technology. Analysis of the 3D brain lesion images and the 3D printed brain lesion models may enable a more efficient and accurate way of determining brain lesion etiologies.

Abstract: The present disclosure provides methods for molecular neighborhood detection of molecules, such as by iterative proximity ligation or split-and-pool methods for obtaining positional information.

Abstract: A method in a data processing system including at least one processor and at least one memory including instructions executed by the at least one processor to implement a lane change system is provided by the present disclosure. The method includes receiving, from at least one of a plurality of sensors coupled to a vehicle, information associated with a location of an object longitudinally ahead of the vehicle, determining a sequence of control inputs associated with a time horizon to avoid a collision between the vehicle and the object based on a constraint and the location of the object, and the determining the sequence of control inputs including minimizing a maximum tire slip angle of the vehicle during the time horizon subject to the constraint, and causing a vehicle control system of the vehicle to perform a vehicle maneuver based on the sequence of control inputs.

Abstract: This disclosure provides systems, methods, and apparatus related to metal-supported proton conducting solid oxide electrochemical devices. In one aspect, a method includes forming an electrode on a metal support of a device with a first proton-conducting ceramic. The metal support comprises an iron-chromium alloy. The first proton-conducting ceramic is in a powder form. An electrolyte layer is formed on the electrode and on the metal support of the device with a second proton-conducting ceramic. The second proton-conducting ceramic is in a powder form. The device is thermally treated at about 1200° C. to 1550° C.

Abstract: Provided herein are energy storage devices high energy and power densities, cycle life, and safety. In some embodiments, the energy storage device comprise a non-flammable electrolyte that eliminate and/or reduce fire hazards for improved battery safety, with improved electrode compatibility with electrode materials.

Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

Abstract: In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a citrate-presenting composition to the population of bone cells. In some embodiments, the citrate-presenting composition is provided to the bone cells at a first stage of cell development selected to obtain a first cell differentiation or phenotype progression. Additionally, in some cases, a second citrate-presenting composition is further provided to the bone cells at a second stage of cell development selected to obtain a second cell differentiation or phenotype progression.