Abstract: A combination collar and muzzle is used as a humane method of restraining, controlling, and achieving obedient behavior of animals, dogs in particular. A collar member or loop encircles the neck immediately behind the ears, and a second loop encircles the upper and lower jaws of the animal to form a type of a figure eight combination collar and muzzle. The two loops are coupled together with a ring behind the jaw. The loops are slidably connected so that when a leash is attached to the portion of the muzzle loop extending out from the connecting ring it will slide easily and at the same time will exert a downward pressure on the neck immediately behind the ears. Pressure is thus simultaneously applied to nerves and muscles tending to control the dog humanely and without choking or applying pressure to the trachea and larynx.

Abstract: A simple method for making EDTA, ED3A or DTPA analogs from amide derivatives of alpha amino acids is disclosed. These EDTA, ED3A or DTPA analogs are useful chelating agents, and preferably are useful as bifunctional chelating agents which may be attached to biological molecules and which form physiologically stable chelates with a variety of metal ions.

Abstract: A novel compound, 4-amino-3-iodobenzylguanidine, in radioiodinated form is useful in radiopharmaceutical compositions in nuclear medicine as an imaging agent for the heart, adrenal medulla, and tumors of the adrenal medulla and can be used for treatment of tumors of the adrenal medulla. The radioactive compound can be readily made by reacting 4-aminobenzylguanidine and an N-chloro oxidant in the presence of a radioiodide.

Abstract: A pyramidal data processing system comprising a plurality of levels of processor arrays, the number of processors in an array increases in number from a level of lowest resolution to a level of highest resolution. Each processor in an array is coupled for data transfer to a neighborhood of processors including laterally and diagnoally adjacent processors in the same level, a processor in the level of next lowest resolution, and processors in the level of next greatest resolution. A memory is associated with each processor to store value of data elements. A controller and control memory generate control signals to perform in synchrony data transformations on selected data elements associated with each neighborhood of processors.

Abstract: An improved, energy efficient, hot rolling method for direct production of cold formable dual-phase steel is provided. The steel is heated to completely austenitize it and then continuously hot rolled and cooled down into the ferrite-austenite two phase region to a temperature which is just below the effective Ar.sub.3 temperature. The hot rolled steel is then rapidly quenched to provide an alloy containing strong, tough lath martensite (fibers) in a ductile soft ferrite matrix. The method is particularly useful for providing rods in which form the alloy is capable of being drawn into high strength wire or the like in a cold drawing operation without any intermediate annealing or patenting, and has excellent strength, ductility and fatigue characteristics.

Abstract: BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation in animals are disclosed.

Abstract: This invention relates to apparatus and the method for preparing corneal tissue for surgical graft, implantation or transplantation referred to herein as "surgical techniques" or "surgical procedures." Use of the apparatus and method for preparing the corneal tissue avoids significant modification of the ultrastructure of corneal tissue during preparation of the tissue samples themselves.

Abstract: Methods and compositions are provided for the detection of a particular low density lipoprotein which has been found to be a marker for patients suffering from type IV hypertriglyceridemia. A monoclonal antibody capable of specifically binding to a characteristic epitopic site on this LDL subspecies can be utilized in a wide variety of immunoassays.Hybridoma cell line SPL.IVA5A1 was deposited at the American Type Culture Collection on Mar. 29, 1984, and granted accession no. HB 8535.

Abstract: Novel hybridomas, human monoclonal antibodies, and their uses are provided. Specifically CLNH5 is a human-human hybridoma which secretes IgM monoclonal antibodies specific for cervical of carcinomas. The monoclonal antibodies can find use in therapy and diagnosis, both in vitro and in vivo.The hybridoma CLNH5 was deposited at the A.T.C.C. for patent purposes as defined in M.P.E.P. 608.01(p) on Jan. 28, 1983 and given A.T.C.C. Accession No. HB8206.

Abstract: Continuous hybrid cell lines for producing monoclonal antibodies, the antibodies specific for an antigenic determinant unique to cervical cancer cells, have been developed. The hybrid cell lines were established by fusing differentiated lymphoid cells primed with intact human cervical cancer cells with myeloma cells, particularly plasmacytoma cells. The resulting fused hybrid cells were cultured in HAT tissue culture media which included a small concentration of deoxycytidine. Deoxycytidine was found to enhance the growth of the hybrid cells and subsequent yield of monoclonal antibodies secreted therefrom. Hybrid cell lines secreting monoclonal antibodies to antigenic determinants unique for human cervical cancer cells can be maintained indefinitely in culture to produce large amounts of homogenous anti-cervical cancer cell antibody.

Abstract: An optically active alpha-amino acid derivative having the formula: ##STR1## wherein: X is OH, Cl, Br, I, or OCOR.sub.3 ;Y is a radical selected to stabilize the alpha carbon atom of the alpha-amino acid derivative sufficiently to prevent significant change in symmetry thereof during replacement of X with an alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, alkenaryl or alkynaryl radical, or such radical having one or more chemical constituents thereon; andR.sub.1 and R.sub.2 are different from one another and are each hydrogen or an alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, alkenaryl, or alkynaryl radical, or such radical having one or more non-protic chemical constituents thereon is conventionally synthesized from the corresponding alpha-amino acid. The ##STR2## portion of the above derivative is converted to a ketone functionality without racemization.

Abstract: A plate of suitable nutrient medium and agar is inoculated with bacteria from a biological sample. Bacterial colonies are cultured on the plate and are then overlaid with a soft agar layer containing bacterial lysing agents. A removable sheet with bound first animal antibodies for cholera toxin is used to contact the overlaid lysed colonies. The sheet is then exposed to a second animal antibody to cholera toxin followed by treatment with a third animal antibody against the second animal antibody, said third animal antibody being coupled to an enzyme capable of generating a chromophoric product. The sheet is then developed by immersion in a substrate and system for the bound enzyme to produce chromophoric products at the sites of enterotoxigenic bacterial colonies.

Abstract: A high strength, high ductility, low carbon, dual phase steel wire, bar or rod and process for making the same is provided. The steel wire, bar or rod is produced by cold drawing to the desired diameter in a single multipass operation a low carbon steel composition characterized by a duplex microstructure consisting essentially of a strong second phase dispersed in a soft ferrite matrix with a microstructure and morphology having sufficient cold formability to allow reductions in cross-sectional area of up to about 99.9%. Tensile strengths of at least 120 ksi to over 400 ksi may be obtained.

Abstract: An infant-sized mannequin is provided for use in training or practicing cardiopulmonary resuscitation involving synchronized insufflation and external cardiac massage manipulations. The mannequin is provided with lung-simulating structure, including a pressure switch transducer actuated by insufflations applied to the mannequin and producing an electrical signal indicative of the rate and pressure of the applied insufflations. The mannequin is also provided with a plunger mechanism actuatable by cardiac massage manipulations applied to the mannequin. The plunger mechanism in turn actuates a potentiometer transducer which produces an electrical signal indicative of the rate and depth of cardiac massage. The electrical signals are conveyed by wire connections to a recorder producing separate record traces of cardiac massage action and insufflation, for providing a visual record of the several CPR parameters indicative of the performance skill of one performing CPR on the mannequin.

Abstract: Functional oxygen transport systems (OTS) have been devised which may serve as temporary blood substitutes in the circulatory system. The OTS comprises pure crystalline hemoglobin dissolved in an aqueous solution and encapsulated within a complex lipid and carbohydrate modified lipid phase. The hemoglobin encapsulated inner aqueous phase and the encapsulating lipid phase are dispensed in an outer isotonic aqueous phase to form a suspension of the multiple water-in-oil-in water emulsion type. The emulsion is suitable to transfusion into the circulatory system to assist in oxygen transport. The carbohydrate modified lipids are included in the lipid phase to "mask" the OTS from the tissue binding and take up by the reticuloendothelial system. The OTS are also suitable for use as calibrating fluids in gas analysis apparatus.

Abstract: An integrated circuit pyroelectric sensor includes two MOSFETS coupled in a differential amplifier configuration, each MOSFET having a common source. A pyroelectric capacitor is coupled to the gate of a respective one of the MOSFET. A polysilicon filament is disposed between the pyroelectric capacitors which acts as a heating element when a current is passed therethrough. The voltage difference between the drain of each MOSFET is thus a function of the voltage difference between the pyroelectric capacitors. One of the pyroelectric capacitors is disposed at the leading edge of the sensor with respect to the direction of a fluid flow. The fluid flow across the sensor will cause the first capacitor to have a different temperature than the other capacitor of the trailing edge of the sensor whose temperature is a function of the temperature of the heating element.

Abstract: A method for controlling the function of a bladder, includes identification of the anatomical location of at least one nerve controlling the muscles for the bladder and/or its sphincter and positioning of an electrode on the nerve to selectively stimulate the nerve for continence and evacuation purposes. The electrode can be implanted in a patient either surgically or percutaneously and may be either removed after proper stimulation has achieved the desired result (neurostimulation) or may be left intact on the nerve for selective stimulation thereof. An electronic control system is disclosed for electrically energizing two or more implanted electrodes in a preselected timed relationship.

Abstract: The disclosure is directed to a wristwatch dosimeter utilizing a CdTe detector, a microprocessor and an audio and/or visual alarm. The dosimeter is entirely housable with a conventional digital watch case having an additional aperture enabling the detector to receive radiation.

Abstract: NMR imaging apparatus having at least one pulsed magnetic field gradient coil generating pulsed magnetic gradient fields and having at least one other coil structure magnetically linked thereto (and therefore subject to induced pulsed currents which create opposing magnetic fields if permitted to flow) includes apparatus connected in circuit with the other coil structure for suppressing such induced currents. The suppression is effected by causing the other coil structure to have increased electrical impedance with respect to such induced currents. Where the other coil structure is a radio frequency transmit/receive coil having plural parallel connected turns, the suppression apparatus includes at least one capacitor in series with at least some of the turns so as to present a substantially open circuit condition at the relatively lower frequencies of the unwanted induced currents.

Abstract: A method for obtaining ovipositional disruption of navel orangeworm. The air of nut orchard area, e.g., almonds, where egg-laying by the moth of the navel orangeworm is expected is permeated, as by spraying, by a composition of matter incorporating as an active ingredient as effective amount of crude almond oil. The composition may be a water emulsion of crude almond oil or may be a water emulsion of a wettable powder formulation containing appreciably equal amounts of crude almond oil and ground almond press cake.