Patents Assigned to The Regents of the University of
  • Ophthalmic implant system for drug delivery
    Patent number: 11399977
    Abstract: An ophthalmic implant configured for peri-operative, intra-operative, or post-operative assembly and disassembly. Drug delivery devices may be implanted with an intraocular lens, and later removed and replaced with new drug delivery devices.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: August 2, 2022
    Assignees: SPYGLASS PHARMA, INC., THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: James R. Dennewill, Malik Y. Kahook, Glenn R. Sussman, Craig Alan Cable, II
  • Method of treating microbial infections
    Patent number: 11400098
    Abstract: The disclosure provides for novel antimicrobial agents, methods of making, and methods of use thereof.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: August 2, 2022
    Assignee: The Regents of the University of California
    Inventors: Richard L. Gallo, Teruaki Nakatsuji
  • Skeletal removal of bisphosphonates
    Patent number: 11400104
    Abstract: Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: August 2, 2022
    Assignees: The Regents of the University of California, BioVinc LLC, University of Southern California
    Inventors: Frank Hallock Ebetino, Ichiro Nishimura, Shuting Sun, Mark Walden Lundy, Akishige Hokugo, Charles McKenna, Keivan Sadrerafi
  • Using synthetic data sets to train a neural network for three-dimensional seismic fault segmentation
    Patent number: 11403495
    Abstract: A machine learning system efficiently detects faults from three-dimensional (“3D”) seismic images, in which the fault detection is considered as a binary segmentation problem. Because the distribution of fault and nonfault samples is heavily biased, embodiments of the present disclosure use a balanced loss function to optimize model parameters. Embodiments of the present disclosure train a machine learning system by using a selected number of pairs of 3D synthetic seismic and fault volumes, which may be automatically generated by randomly adding folding, faulting, and noise in the volumes. Although trained by using only synthetic data sets, the machine learning system can accurately detect faults from 3D field seismic volumes that are acquired at totally different surveys.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: August 2, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Xinming Wu, Yunzhi Shi, Sergey Fomel
  • Compositions and methods for treatment of homocystinuria
    Patent number: 11400143
    Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: August 2, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Jan P. Kraus, Tomas Majtan, Erez Bublil
  • Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
    Patent number: 11401532
    Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: August 2, 2022
    Assignees: The Regents of the University of California, University of Vienna
    Inventors: Jennifer A. Doudna, Martin Jinek, Krzysztof Chylinski, Emmanuelle Charpentier
  • Methods of producing polyol lipids
    Patent number: 11401539
    Abstract: Provided are methods and yeast cultures for producing polyol lipids and polyol lipid compositions.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: August 2, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kyria Boundy-Mills, Luis Antonio Garay Almada, Irnayuli Rosaleida Sitepu, J. Bruce German, Tomas Cajka, Oliver Fiehn
  • Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling
    Patent number: 11400108
    Abstract: Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: August 2, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Maria Emilia Di Francesco, Philip Jones, Michael A. Curran
  • Method of transcutaneous electrical spinal cord stimulation for facilitation of locomotion
    Patent number: 11400284
    Abstract: In various embodiments, non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries are provided. In some embodiments the methods involve administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces locomotor activity.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: August 2, 2022
    Assignee: The Regents of the University of California
    Inventors: Yury P. Gerasimenko, Victor Reggie Edgerton, Roland R. Roy, Daniel C. Lu
  • Small molecules for the treatment of autoimmune disorders
    Patent number: 11400096
    Abstract: Certain embodiments are directed to methods of treating autoimmune disorders by administering P2 purnergic receptor antagonist and/or adenosine receptor antagonists. The P2 purnergic receptor antagonist being chemical analogs of adenosine receptor antagonist 8-Ethoxy-9-ethyl-9H-purin-6-amine. The adenosine receptor antagonists being chemical analogs of the non-hydrolysable ATP analog adenosine 5?[?-thio]triphosphate (ATP?S). Certain embodiments are directed to the use of the chemical analogs to modulate IL-17 activity.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: August 2, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventor: Jean X. Jiang
  • Apparatus and method for measuring toe flexion and extension
    Patent number: 11402284
    Abstract: A toe dynamometer is configured to accurately and precisely measure toe extensor strength. The toe dynamometer includes a platform configured to accommodate a patient's foot, and a sensor assembly comprising a force sensor and a toe cap connected to the force sensor. The force sensor is configured to measure forces applied to the force sensor by toe flexion on the force sensor and from toe extension away on the force sensor through the toe cap.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: August 2, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Hongwu Wang, Elizabeth Hile, Mustafa Ghazi
  • Quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof
    Patent number: 11401243
    Abstract: The present invention relates to quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), the preparation thereof and uses thereof. Formula (I).
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: August 2, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Stanley Watowich, Harshini Neelakantan, Hua-Yu Wang, Stanton Mchardy
  • All silicon broadband ultra-violet metasurfaces
    Patent number: 11402543
    Abstract: A device has a substrate transparent to ultraviolet (UV) light, and at least one metalens formed of a material having large permittivity of UV light on the substrate. A device has a UV reflector, a UV transparent film on the reflector, and at least one metalens formed of a material having large permittivity of UV light on the film.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: August 2, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yang Deng, Xi Wang, Zilun Gong, Jie Yao
  • Generation of airway basal stem cells from human pluripotent stem cells
    Patent number: 11401510
    Abstract: Described herein is a method of generating in-vitro differentiated airway basal cells and compositions thereof. Also described herein is a method of treating a pulmonary disease comprising administering the in-vitro differentiated airway basal cells and compositions thereof. In another aspect, described herein is a disease model comprising patient-derived or genetically modified in-vitro differentiated airway basal cells and compositions thereof.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: August 2, 2022
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Finn Joseph Hawkins, Darrell N. Kotton, Shingo Suzuki, Brian R. Davis, Cristina Barillà
  • Single screen fabrication of symmetric multilayer magnetic resonance imaging (MRI) receive coils
    Patent number: 11402446
    Abstract: Methods for forming flexible magnetic resonance imaging (MRI) receive coil devices having at least one receive coil with at least one capacitor are provided and include providing a flexible substrate having a first surface and a second surface opposite the first surface, forming a first conductor pattern on the first surface by printing a first layer of conductive material on the first surface using a printing mask having a pattern, and forming a second conductor pattern on the second surface by printing a second layer of conductive material on the second surface using the same printing mask or identical printing mask, wherein a portion of the first conductor pattern on the first surface overlaps with a portion of the second conductor pattern on the second surface with the flexible substrate therebetween to form the at least one capacitor element.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: August 2, 2022
    Assignee: The Regents of the University of California
    Inventors: Shimon Michael Lustig, Ana Claudia Arias, Joseph R. Corea, Anita M. Flynn
  • Post-operative surgical site wound treatment and method for device removal
    Patent number: 11400203
    Abstract: A device and method for treatment of post-operative surgical site wounds. Device includes an elongated hollow shaft that spans from the wound closure to the deep wound area, the internal end abutting a wound dressing and the external end connecting to a device that can provide negative-pressure suction and irrigation. Device providing one or more of irrigation, suction, and/or local antibiotic delivery to deep infections through a closed-wound. The method for removal includes narrowing a removal element relative to the long axis, collapsing the wound dressing; removing the wound dressing through the elongated shaft; and removing the device through a closed wound, avoiding a second removal surgery.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: August 2, 2022
    Assignees: Cor Medical Ventures, Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Vikas Patel, Christopher Kleck, Brian Bowman, Tina John, Jude Paganelli
  • METHOD AND DEVICE FOR IMAGING FLUORESCENT PROTEINS IN NEAR- AND SHORT-WAVE INFRARED
    Publication number: 20220236280
    Abstract: The present invention relates to systems, methods and fluorescent polypeptide for real-time multicolor shortwave infrared fluorescence imaging. The systems and methods of the present invention further relate to real-time multi-color in vivo SWIR imaging systems employing high-power excitation sources in combination with state of the art InGaAs SWIR detectors and SWIR illuminated fluorescent polypeptide.
    Type: Application
    Filed: June 7, 2020
    Publication date: July 28, 2022
    Applicants: HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH), THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Oliver BRUNS, Jakob LINGG, Juan-Pablo FUENZALIDA-WERNER, Andre STIEL, Martin WARMER, Shyam S. RAMAKRISHNAN,, Emily COSCO, Ellen SLETTEN
  • MUTANTS AND DRUG CONJUGATES OF R-SPONDINS AND USE THEREOF
    Publication number: 20220233704
    Abstract: Recombinant R-spondin (RSPO) polypeptides are provided, such as RSPO that is fused with Fc and/or comprises a conjugated therapeutic agent. Methods for using such polypeptides, for example in treating cancer are also provided.
    Type: Application
    Filed: January 27, 2022
    Publication date: July 28, 2022
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Qingyun J. LIU, Kendra S. CARMON, Soohyun PARK, Jie CUI
  • METHODS FOR PREPARATION OF ACTIVE SEPARASE
    Publication number: 20220235345
    Abstract: Provided herein are polypeptide constructs containing a securin, e.g., a full-length securin or a truncated securin, fused to a separase. The polypeptide constructs may further contain linker peptides, protease recognition sites, and unfoldase recognition sites to facilitate expression and/or purification. Methods for obtaining the polypeptide constructs with active separase activity are also described, as well as methods for identify separase modulator compounds such as separase inhibitors.
    Type: Application
    Filed: June 24, 2020
    Publication date: July 28, 2022
    Applicant: Regents of the University of California
    Inventors: Laura E. Rosen, David O. Morgan
  • COMPOSITIONS AND METHODS OF FABRICATION OF NEAR INFRARED DEVICES
    Publication number: 20220235067
    Abstract: A composition of matter including a donor including a dithiophene unit combined with a non-fullerene acceptor. Further disclosed is a device comprising an active region including the composition of matter. Example devices include a solar cell or a photodetector.
    Type: Application
    Filed: June 26, 2020
    Publication date: July 28, 2022
    Applicant: The Regents of the University of California
    Inventors: Guillermo C. Bazan, Jaewon Lee, Seyeong Song, Ziyue Zhu, Thuc-Quyen Nguyen, Seo-Jin Ko