Patents Assigned to The Regents of the University of
  • Compositions, devices, systems, and methods for using a nanopore
    Patent number: 9481908
    Abstract: The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: November 1, 2016
    Assignee: The Regents of the University of California
    Inventors: Felix A. Olasagasti, Kathy R. Lieberman, Seico Benner, Mark A. Akeson
  • Method of destroying and preventing bacterial and fungal biofilm by amino acid infusion
    Patent number: 9480669
    Abstract: Disclosed is a method comprising the administration of a 3% amino acid and 3% glycerin solution for the use of prevention and disruption of bacterial biofilms. Also disclosed is method comprising the administration of L-cysteine 0.4 g per 100 ml for the prevention and destruction of fungal biofilms.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: November 1, 2016
    Assignee: The Regents of The University of California
    Inventors: Thomas Benedict Bryan, Clarissa J. Nobile
  • Digital microfluidic platform for radiochemistry
    Patent number: 9481615
    Abstract: Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing 18F.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: November 1, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: R. Michael Van Dam, Chang-Jin Kim, Supin Chen, Huijiang Ding, Gaurav Jitendra Shah, Pei Yuin Keng
  • RNA silencing in animals as an antiviral defense
    Patent number: 9481886
    Abstract: The present invention provides recombinant DNA constructs for inactivation of viral or endogenous genes in a cell, wherein the construct comprises viral sequence sufficient to activate RNA silencing. In another aspect, the invention provides methods for identifying RNA silencing suppressors by sequence analysis and functional tests. In yet another aspect, the invention provides a method for identifying inhibitors of RNA silencing suppressors. In still other aspects, the invention comprises methods for identifying genes in the antiviral RNA silencing pathway, enhancers of the antiviral pathway, and methods of treating or preventing viral infections using enhancers of the pathway.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: November 1, 2016
    Assignee: The Regents of the University of California
    Inventors: Shou-Wei Ding, Hong-Wei Li, Wan-Xiang Li
  • Method and apparatus for scanning detection
    Patent number: 9482611
    Abstract: An apparatus for scanning and detecting analytes in real time as they move through a separation conduit is provided. The apparatus may include a detector mounted on a scanner containing a separation conduit positions under the scanner such that the scanner may move back and forth along the conduit, producing time and space data of the column as the analyte moves through and providing information regarding elution of the analyte in real time. A method for real time analysis of analytes as they move through a separation conduit is also provided.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: November 1, 2016
    Assignee: Board of Regents, The University of Texas System
    Inventors: Purnendu K. Dasgupta, Brian N. Stamos
  • Seriniquinones, melanoma-specific anticancer agents
    Patent number: 9481662
    Abstract: There are provided, inter alia, derivatives of seriniquinone and methods useful for the treatment of cancer, and in particular treatment of melanoma and prostate cancer.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: November 1, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: William Fenical, Paul R. Jensen, James J. La Clair, Lynnie Trzoss, Takashi Fukuda
  • Acrylic polymers containing metallic nanoparticles
    Patent number: 9480260
    Abstract: Methods of forming antimicrobial polymeric materials comprising metallic nanoparticles are disclosed. Such methods generally comprise: combining a metal-containing material with a resin in situ; and curing the resin in the presence of a metal-containing material. Antimicrobial polymeric materials formed by said methods are also disclosed.
    Type: Grant
    Filed: June 7, 2014
    Date of Patent: November 1, 2016
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Kyumin Whang, H. Ralph Rawls, Barry K. Norling
  • Lectins and uses thereof
    Patent number: 9481717
    Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides antiviral and antimicrobial lectin compounds and methods of their use.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: November 1, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David Markovitz, Michael Swanson, Irwin Goldstein, Harry Winter
  • Mineralization and biological modification of biomaterial surfaces
    Patent number: 9480773
    Abstract: Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: November 1, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: William L. Murphy, Martin C. Peters, David J. Mooney
  • PHASE NOISE MEASUREMENT AND FILTERING CIRCUIT
    Publication number: 20160315601
    Abstract: Methods and apparatuses for measuring a phase noise level in an input signal are disclosed. An input signal can be delayed to generate a delayed version of the input signal. Next, a phase difference can be detected between the input signal and the delayed version of the input signal. A phase noise level in the input signal can then be determined based on the detected phase difference. The measured phase noise level can then be used to suppress phase noise in the input signal.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Applicant: The Regents of the University of California
    Inventor: Qun Gu
  • FAST THREE DIMENSIONAL T2 WEIGHTED BALANCED STEADY-STATE FREE PRECESSION IMAGING
    Publication number: 20160313427
    Abstract: A fast 3D T2-weighted imaging system and method is disclosed that uses balanced steady state free precession (bSSFP), variable flip angles, and an interleaved multi-shot spiral-out phase encode ordering strategy to acquire high resolution T2-weighted images quickly while maintaining spatial resolution.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniel B. Ennis, Subashini Srinivasan, Holden H. Wu
  • TUSC2 THERAPIES
    Publication number: 20160310569
    Abstract: A method for predicting a subject's response to a TUSC2 therapy is provided. In particular, a subject's response is predicted based on the proportion of cancers cells that are apoptotic. Also provided is a method of treating a subject previously predicted to have a favorable response with a TUSC2 therapy. Methods for treating cancer by administration of a TUSC2 therapeutic in conjunction with an EGFR inhibitor and/or a protein kinase inhibitor are also disclosed. Kits and reagents for use in TUSC2 therapy are provided.
    Type: Application
    Filed: July 11, 2016
    Publication date: October 27, 2016
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jack ROTH, David STEWART, Charles LU, Ignacio I. WISTUBA, Shaoyu YAN, Maria I. NUNEZ
  • MODULATION OF NKG2D
    Publication number: 20160311906
    Abstract: The present invention relates to methods and compositions for treating and/or preventing inflammation associated with viral infection and solid organ transplant rejection. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D.
    Type: Application
    Filed: March 25, 2016
    Publication date: October 27, 2016
    Applicant: The Regents of the University of California
    Inventors: Lewis L. LANIER, Koetsu OGASAWARA, Jeffrey A. BLUESTONE
  • PHOTOVOLTAIC DESALINATION SYSTEM
    Publication number: 20160310899
    Abstract: A photovoltaic desalination system can comprise a solar cell, configured to receive solar radiation, including an n-doped semiconductor layer, a p-doped semiconductor layer, the two semiconductor layers forming a p-n junction, and an channel array, formed in the p-n junction; an input reservoir, coupled to the solar cell, the input reservoir configured to contain a salty fluid, and to release the salty fluid to the solar cell; an output fluid management system, coupled to the solar cell, the output fluid management system configured to receive an output fluid from the solar cell; wherein the channel array is configured to receive the salty fluid from the input reservoir, and to output the output fluid to the output fluid management system.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Applicant: The Regents of the University of California
    Inventors: Yemaya C. Bordain, Manas Ranjan Gartia, Gang Logan Liu, Lisa Plucinski, Luman Qu, Harry B. Radousky, Brent Trenhaile, Gergely T. Zimanyi
  • Mapping cell identity determinants in chromatin
    Publication number: 20160312267
    Abstract: The invention provides materials and methods to identify and analyze in a genome-wide manner the structural determinants of this organization. Next generation sequencing methods, combined with a novel assay and integrated data analysis, are used to map the long-range interactions in chromatin that are involved in the regulation of transcription.
    Type: Application
    Filed: April 26, 2016
    Publication date: October 27, 2016
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zbyszek Otwinowski, Dominika Borek
  • VARIABLE THICKNESS DIAPHRAGM FOR A WIDEBAND ROBUST PIEZOELECTRIC MICROMACHINED ULTRASONIC TRANSDUCER (PMUT)
    Publication number: 20160315247
    Abstract: A diaphragm for a piezoelectric micromachined ultrasonic transducer (PMUT) is presented having resonance frequency and bandwidth characteristics which are decoupled from one another into independent variables. Portions of at least the piezoelectric material layer and backside electrode layer are removed in a selected pattern to form structures, such as ribs, in the diaphragm which retains stiffness while reducing overall mass. The patterned structure can be formed by additive, or subtractive, fabrication processes.
    Type: Application
    Filed: April 21, 2016
    Publication date: October 27, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Bernhard Boser, David Horsley, Richard Przybyla, Ofer Rozen, Stefon Shelton
  • POLYMER NETWORK SINGLE ION CONDUCTORS
    Publication number: 20160315348
    Abstract: The disclosure provides for polymer networks that can effectively conduct single ion electrolytes.
    Type: Application
    Filed: December 8, 2014
    Publication date: October 27, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jeffrey R. Long, Jeffrey Van Humbeck, Rob P. Ameloot
  • FABRICATION AND APPLICATION OF NANOFIBER RIBBONS AND SHEETS AND TWISTED AND NON-TWISTED NANOFIBER YARNS
    Publication number: 20160312387
    Abstract: A device including an array of aligned conductive channels. The conductive channels are operable for directional transport of species selected from the group consisting of electrons, ions, phonons, and combinations thereof. The conductive channels are provided for by nanofibers in a form selected from the group consisting of ribbons, sheets, yarns, and combinations thereof.
    Type: Application
    Filed: July 1, 2016
    Publication date: October 27, 2016
    Applicant: Board of Regents, The University of Texas System
    Inventors: Mei Zhang, Shaoli Fang, Ray H. Baughman, Anvar A. Zakhidov, Kenneth Ross Atkinson, Ali E. Aliev, Sergey Li, Chris Williams
  • CHARGED PARTICLE BEAM PROCESSING OF THERMOELECTRIC MATERIALS
    Publication number: 20160315243
    Abstract: This disclosure provides systems, methods, and apparatus related to thermoelectric materials. In one aspect, a thermoelectric material is provided. The thermoelectric material is then irradiated with charged particles to generated native defects in the thermoelectric material. The charged particles have energies of 100 keV or greater. The irradiation of the thermoelectric material may improve its thermoelectric properties.
    Type: Application
    Filed: March 4, 2016
    Publication date: October 27, 2016
    Applicant: The Regents of the University of California
    Inventors: Junqiao Wu, Joonki Suh, Kin M. Yu, Wladyslaw Walukiewicz
  • FLYWHEEL/BATTERY HYBRID ENERGY STORAGE AND POWER MANAGEMENT SYSTEM
    Publication number: 20160311325
    Abstract: A hybrid/electric vehicle power management system in which an Inertial Storage and Recovery System (INSTAR) utilizes an enhanced Flywheel Energy Storage (FES) system to reach higher vehicle efficiencies. INSTAR allows regenerative braking energy surges to be readily stored at high efficiency on the flywheel, whose energy is then converted to power for driving the motors, or charging the batteries at an efficient charging rate.
    Type: Application
    Filed: April 21, 2016
    Publication date: October 27, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dennis K. Lieu, Daniel R. Talancon