Abstract: Antibodies that bind to ?v?8 are provided.

Abstract: Systems and methods for training and implementing a sensorimotor control framework in accordance with embodiments of the invention are illustrated. One embodiment includes a method for operating a sensorimotor control framework. The method includes steps for determining a current state of a musculoskeletal model, determining a desired state of the musculoskeletal model, computing a set of muscle activations, based on a difference between the current and desired states, and driving a musculoskeletal model based on the computed muscle activations.

Abstract: Provided are methods of analyzing capped ribonucleic acids (RNAs). The methods include translocating an adapted RNA through a nanopore of a nanopore device. The adapted RNA includes an RNA region, a 5? cap, and an adapter polynucleotide attached to the 5? cap. The methods include monitoring ionic current through the nanopore during the translocating, translocating the 5? cap through the nanopore, and identifying one or more ionic current features characteristic of the 5? cap (e.g., a triphosphate linkage between the 5? cap and nucleotide N1 of the RNA region, a 5? to 5? orientation of the 5? cap and nucleotide N1 of the RNA region, and/or the like), translocating through the nanopore. Also provided are computer-readable media, computer devices, and systems that find use, e.g., in practicing the methods of the present disclosure.

Abstract: The present disclosure provides a high-performance integrated strain sensing device that is highly stretchable, rehealable, recyclable and reconfigurable. This device can include dynamic covalent thermoset polyimine as the substrate and encapsulation, eutectic liquid metal alloy as the strain sensing unit and interconnects, and off-the-shelf chip components for measuring and magnifying functions. The device can be attached on the knee, elbow, wrist and finger joints for strain sensing and motion monitoring, and can also be attached on the abdomen to accurately measure respiration cycles.

Abstract: Systems and methods for generative adversarial networks (GANs) to remove artifacts from undersampled magnetic resonance (MR) images are described. The process of training the GAN can include providing undersampled 3D MR images to the generator model, providing the generated example and a real example to the discriminator model, applying adversarial loss, L2 loss, and structural similarity index measure loss to the generator model based on a classification output by the discriminator model, and repeating until the generator model has been trained to remove the artifacts from the undersampled 3D MR images. At runtime, the trained generator model of the GAN can be generate artifact-free images or parameter maps from undersampled MRI data of a patient.

Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

Abstract: Disclosed are reversibly-expandable polymer-integrated crystals (PIX) materials, devices, and methods for controllably encapsulating and releasing molecular cargo. The disclosed PIX materials are engineered crystalline materials with large pores that can entrap macromolecules, such as proteins and nanoparticles. The material expands and contracts reversibly, allowing controlled encapsulation and release of guest/cargo molecules.

Abstract: Provided are methods for simultaneously detecting analytes. The methods include exposing a tip of a nanosensor to a biological sample, measuring ionic current flow through the nanosensor tip to detect a first analyte and a second analyte in the biological sample, and distinguishing the first analyte from the second analyte based on a first diffusion limited current peak resulting from binding of a first specific binding member to the first analyte being distinguishable from a second diffusion limited current peak resulting from binding of a second specific binding member to the second analyte. Sensing apparatuses that find use, e.g., in practicing the methods of the present disclosure, are also provided.

Abstract: A system, apparatus and method are provided for robotically assisting the harvest of a crop. Instrumented picker carts include sensors for detecting amounts of harvested crop (e.g., fill ratios) of containers carried by the carts, communication modules for communicating their locations and detected crop amounts to a field computer, and components for signaling for robotic service. The field computer predicts when a cart that requests service will have a full container and where it will be located at that time, then decides whether to approve the request. If the request is approved, a robot is assigned and is given (or generates) a path to the cart's predicted location, and begins moving toward the location so as to arrive near (and preferably before) the predicted time. Robots include means for moving (e.g., wheels, motors, steering components, power sources), navigation modules, computing components for controlling their movement, and communication modules.

Abstract: This disclosure provides systems, methods, and apparatus related to metal-supported proton conducting solid oxide electrochemical devices. In one aspect, a method includes forming an electrode on a metal support of a device with a first proton-conducting ceramic. The metal support comprises an iron-chromium alloy. The first proton-conducting ceramic is in a powder form. An electrolyte layer is formed on the electrode and on the metal support of the device with a second proton-conducting ceramic. The second proton-conducting ceramic is in a powder form. The device is thermally treated at about 1200° C. to 1550° C.

Abstract: Systems and methods are provided for a mechanical actuator based on a fiber optic platform. A material that is configured to be activated by light is incorporated into an optical fiber that serves as both an actuator and a power delivery network. This platform is adaptable to different materials, types of motions, and length scales and allows for precise delivery of photons to the material.

Abstract: The present embodiments relate to a soft magnetic composite synthesized via spark plasma sintering with both high saturation magnetic polarization and high electrical resistivity for efficient soft magnetic cores. CoFe powder particles coated with an insulating layer of Al2O3 were used as feedstock material to improve the electrical resistivity while retaining high saturation magnetic polarization. By maintaining a continuous non-magnetic Al2O3 phase throughout the material, both a high saturation magnetic polarization, above 1.5 T, and high electrical resistivity, above 100 ??·m, were achieved. Through microstructural characterization of samples consolidated at various temperatures, the role of microstructural evolution on the magnetic and electronic properties of the composite was elucidated.

Abstract: New antibodies and methods of use are described.

Abstract: Provided herein are methods for detecting a RAS pathway mutations in a subject. The methods include obtaining a biological sample from the subject, isolating nucleic acids from the biological sample, and analyzing the expression level of extracellular RNAs in the nucleic acids, wherein a differential expression level of the extracellular RNAs compared to a control sample indicates that the subject has a RAS pathway mutation.

Abstract: Nearly all existing direct current (DC) chemical vapor sensing methodologies are based on charge transfer between sensor and adsorbed molecules. However, the high binding energy at the charge-trapped sites, which is critical for high sensitivity, significantly slows sensors' response and makes the detection of non-polar molecules difficult. By exploiting the incomplete screening effect of graphene, this disclosure demonstrates a DC graphene electronic sensor for rapid (sub-second) and sensitive (ppb) detection of a broad range of vapor analytes, including polar, non-polar, organic and inorganic molecules. Molecular adsorption induced capacitance change in the graphene transistor is revealed to be the main sensing mechanism. This work provides an avenue for a broad spectrum real-time gas sensing technology and serves as an ideal testbed for probing molecular physisorption on graphene.

Abstract: Prodrugs of antibiotic teixobactin, methods of their synthesis, and methods of their use as antimicrobial treatments are described. The teixobactin prodrugs incorporate one or more O-acyl linkages. The O-acyl linkages can be utilized in substitution of amide peptide bonds between an amino acid containing an alcohol side chain and the immediately preceding amino acid.

Abstract: Methods and apparatuses for treating a patient having a brain lesion (e.g., a stroke patient) by applying a charge-balanced, low-frequency alternating current stimulation (ACS) to a region of the patient's brain immediately before and/or during a directed movement. The charge-balanced, low-frequency ACS may have a depolarizing phase that is slower than the hyperpolarizing phase (e.g., the depolarizing phase may have a frequency of 15 Hz or less and the hyperpolarizing phase with a frequency greater than 15 Hz). The ACS stimulation field may be greater than 1.5 V/m. The ACS may be applied during a preferred excitation phase.

Abstract: The present invention relates to methods for synthesizing mixed disulfide conjugates of thienopyridine compounds with a genetically engineered variant of cytochrome P450 BM3 or CYP102A1 as a catalyst, and belongs to the field of chemical synthesis.

Abstract: Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens.

Abstract: An acoustic lens to steer an acoustic beam includes a first structure, a second structure spaced from the first structure, an array of projections disposed between the first and second structures, each projection of the array of projections extending from the first structure toward the second structure to define a respective gap between the projection and the second structure, and an actuator configured to move the first structure, the second structure, or the array of projections for collective adjustment of the respective gaps of the array of projections. Each projection is configured to define one or more respective unit cells, each unit cell having a sub-wavelength size relative to the acoustic beam to establish an effective refractive index profile for the acoustic beam between the first and second structures.