Abstract: Described are methods for treating, preventing, or reducing the risk of, miscarriages, especially recurrent miscarriages. The methods comprise administering to a female subject a therapeutic agent that modulates the activity or binding of components of the complement system, together with a pharmaceutically acceptable carrier. For example, the therapeutic agent can be a C3-convertase inhibitor, an antibody against C5, an antagonist of the C5a receptor, or an antibody against factor B or factor D. Screening methods for agents that can prevent or reduce the risk of miscarriages, especially recurrent miscarriages, are also described.
Type:
Application
Filed:
May 13, 2004
Publication date:
May 31, 2007
Applicants:
New York Society for the Ruptured and Crippled Maintaining The Hospital for Special Surgery, The Regents of the Universuty of Colorado
Inventors:
Jane Salmon, Guillermina Girardi, V. Holers