Abstract: Systems and methods for generalized precursor pattern discovery that work with a wide range of biomedical signals and applications to detect a wide range of medical events are disclosed. In some embodiments, the methods and systems do not require domain-specific knowledge or significant reconfiguration based on the medical event being analyzed, hence it is also possible to discover patterns previously unknown to experts. In some embodiments, to build precursor pattern detection models, the system obtains annotated monitoring data. Positive and negative segments are extracted from the annotated monitoring data, and are preprocessed. Features are extracted from the preprocessed segments, and selected features are chosen from the extracted features. The selected features are classified to create the precursor pattern detection model The precursor pattern detection model may then be used in real time to detect occurrences of the medical event of interest.

Abstract: The present disclosure provides methods of decoding speech from brain activity data. Aspects of the methods include receiving brain speech activity data from a subject, and processing the brain speech activity data to output speech feature data. Also provided are devices and systems for practicing the subject methods.

Abstract: The present technology provides microfabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.

Abstract: The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and/or RNA during and following a clinical treatment regime. The methods may also be used to evaluate protein and/or metabolite levels that correlate with such clinical conditions. The methods are also of use to ascertain the probability outcome for a patient's particular prognosis.

Abstract: Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Platelet-type 12-(S)-LOX (12-LOX) is of particular interest because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Disclosed herein is the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold. The compounds display nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In addition to possessing favorable ADME properties, the compounds also inhibit PAR-4 induced aggregation and calcium mobilization in human platelets, and reduce 12-HETE in mouse/human beta cells.

Abstract: Methods, systems, and devices are disclosed for imaging particles and/or cells using flow cytometry. In one aspect, a method includes transmitting a light beam at a fluidic channel carrying a fluid sample containing particles; optically encoding scattered or fluorescently-emitted light at a spatial optical filter, the spatial optical filter including a surface having a plurality of apertures arranged in a pattern along a transverse direction opposite to particle flow and a longitudinal direction parallel to particle flow, such that different portions of a particle flowing over the pattern of the apertures pass different apertures at different times and scatter the light beam or emit fluorescent light at locations associated with the apertures; and producing image data associated with the particle flowing through the fluidic channel based on the encoded optical signal, in which the produced image data includes information of a physical characteristic of the particle.

Abstract: Electrophoretic separation devices and methods for using the same are provided. Aspects of the devices include a polymeric separation medium that includes a plurality of microwells. Also provided are methods, systems and kits in which the subject devices find use. The devices and methods find use in a variety of different electrophoretic separation applications.

Abstract: Methods, pharmaceutical compositions, and kits are provided for treating a subject with an effective amount of an oxytocin receptor (OXTR) agonist and an effective amount of an ALK5 antagonist. In certain aspects, the OXTR agonist may be oxytocin or an oxytocin analog (e.g., a small molecule). The ALK 5 antagonist may be a small molecule, such as 2-(3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, LY2157299, A 83-01, D 4476, GW 788388, LY 364947, Rep Sox, SB 431542, SB 505124, SB 525334, or SD 208. In certain aspects, the amounts of the OXTR agonist and ALK5 antagonist may be sufficient to induce muscle regeneration and/or neural cell regeneration in the subject.

Abstract: The present invention provides for a library or an array of two or more nucleic acids encoding portions of genes selected from a set of 27 genes which are useful for predicting lung cancer survival, and a method for predicting a subject's overall survival (OS) from a lung cancer using two or more genes selected from the set of 27 genes.

Abstract: We identified 17 transcription factor genes that regulate lipid production and activity in an organism. We subsequently detailed characterization of one of them (psr1). Constructs, methods and systems for enhancing or increasing lipid production in an organism are described.

Abstract: Antimicrobial molecules, their synthesis and use as antimicrobial treatments are described. The antimicrobial compounds are teixobactin analogues. Methods of synthesizing antimicrobial teixobactin analogues are also provided. Antibiotic therapeutics comprising antimicrobial teixobactin analogues are provided, along with methods of and formulations for treating microbial infections using such antimicrobial teixobactin analogues. Prodrugs formed using esterified forms of antimicrobial teixobactin analogues may also be provided.

Abstract: Provided are methods of treating muscle and liver disorders, and for increasing mitochondrial mass and/or functionality in a mammalian myocyte and/or hepatocyte.

Abstract: Orthodontic brackets promote the formation of bacterial biofilms in the human oral cavity, which lead to a variety of oral health problems, including plaque, gingivitis, and white spot lesions. Disclosed herein are methods and compositions for the preventing or inhibiting biofilm formation and associated diseases.

Abstract: III-nitride vertical transistors and methods of making the same are disclosed. The transistors can include aperture regions that are formed using ion implantation. The resulting transistors can have improved properties.

Abstract: Composite materials having superior material properties useful as impact absorbing devices can be fabricated by embedding a lattice structure (e.g., polymer lattice structure) within a foam, so that the foam reinforces the lattice structure under impact. Materials and dimensions of the foam and the lattice structure may be selected to achieve composite materials having tailored impact absorbing elastic and/or viscoelastic responses over a wide range of temperatures.

Abstract: Provided herein, among other things, is a conjugate comprising a polymerase and a nucleoside triphosphate, where the polymerase and the nucleoside triphosphate are covalently linked via a linker that comprises a cleavable linkage. A set of such conjugates, where the conjugates correspond to G, A, T (or U) and C is also provided. Methods for synthesizing a nucleic acid of a defined sequence are also provided. The conjugates can also be used for sequencing applications.

Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.

Abstract: A metal matrix nanocomposite includes: 1) a matrix including one or more metals; and 2) nanostructures uniformly dispersed and stabilized in the matrix at a volume fraction, including those greater than about 3% of the nanocomposite.

Abstract: Embodiments described herein relate to semiconductor and metal substrate surface preparation and controlled growth methods. An example application is formation of an atomic layer deposition (ALD) control layer as a diffusion barrier or gate dielectric layer and subsequent ALD processing. Embodiments described herein are believed to be advantageously utilized concerning gate oxide deposition, diffusion barrier deposition, surface functionalization, surface passivation, and oxide nucleation, among other processes. More specifically, embodiments described herein provide for silicon nitride ALD processes which functionalize, passivate, and nucleate a SiNx monolayer at temperatures below about 300° C.

Abstract: A single-phase DC/AC inverter has a single-phase inverter bridge with binary switches connected to an RLC low-pass filter. Digital control logic in a control circuit (or in a microcontroller) determines and controls a logic state q determining the position of the switches in the inverter bridge from sensed iL, vC values from the RLC filter. The control logic selects one of multiple possible logic states q based on whether the sensed iL, vC values belongs one of multiple boundary regions of a tracking band in an iL, vC state space.