Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.
Type:
Grant
Filed:
September 24, 2015
Date of Patent:
April 24, 2018
Assignees:
The Regets of the University of California, The Scripps Research Institute
Inventors:
Leonard H. Rome, Valerie A. Kickhoefer, Glen Nemerow, Cheng-Yu Lai, Christopher Wiethoff, Mu Han