Patents Assigned to The Research and Development Institute, Inc.
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Patent number: 6654394Abstract: Techniques for stabilizing a laser at a selectable frequency include splitting an output beam from an electrically adjustable laser into a first beam and a second beam. The second beam is transmitted through a modulator. Then the second beam is transmitted through a transient spectral hole burning material onto a detector. The laser is electronically adjusted in response to a detector output from the detector which senses the changes in the modulated second beam after it passes through the transient spectral hole burning material.Type: GrantFiled: July 17, 2002Date of Patent: November 25, 2003Assignee: The Research and Development Institute, Inc.Inventors: Peter B. Sellin, Nicholas M. Strickland, John L. Carlsten, Rufus L. Cone
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Publication number: 20030072775Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.Type: ApplicationFiled: February 14, 2002Publication date: April 17, 2003Applicant: The Research and Development Institute Inc.Inventors: Jim E. Cutler, Yongmoon Han, Pati M. Glee, Bruce L. Granger
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Patent number: 6516014Abstract: Techniques for stabilizing a laser (110) at a selectable frequency include splitting an output beam from an electrically adjustable laser into a first beam (369) and a second beam (361). The second beam is transmitted through a modulator (112). Then the second beam is transmitted through a spectral hole burning material (310) onto a detector (120). The laser is electronically adjusted in response to a detector output from the detector which senses the changes in the modulated second beam after it passes through the spectral hole burning material.Type: GrantFiled: August 21, 2001Date of Patent: February 4, 2003Assignee: The Research and Development Institute, Inc.Inventors: Peter B. Sellin, Nicholas M. Strickland, John L. Carlsten, Rufus L. Cone
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Patent number: 6403090Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.Type: GrantFiled: June 17, 1999Date of Patent: June 11, 2002Assignee: The Research and Development Institute Inc.Inventors: Jim E. Cutler, Yongmoon Han
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Publication number: 20020054886Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans. Monoclonal antibodies for use in passive immunization against candidal infections.Type: ApplicationFiled: December 11, 2000Publication date: May 9, 2002Applicant: The Research and Development Institute Inc.Inventors: Jim E. Cutler, Yongmoon Han
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Patent number: 6309642Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.Type: GrantFiled: May 13, 1998Date of Patent: October 30, 2001Assignee: The Research and Development Institute, Inc.Inventors: Jim E. Cutler, Pati M. Glee
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Patent number: 6180389Abstract: A virion-constrained nanoparticle of the invention comprises a shell of a virion coat protein(s) that encapsulates a core non-viral material, which is organic, inorganic or organometallic in nature. A particularly preferred virion coat is that of cowpea chlorotic mottle virus (CCMV). Encapsulation of a desired particle is effected by adjusting reaction conditions, e.g., by lowering the pH of a solution containing the virion protein and the non-viral substance. Processes for producing the virion-constrained nanoparticles of the invention are also described.Type: GrantFiled: January 3, 1997Date of Patent: January 30, 2001Assignee: The Research and Development Institute, Inc.Inventors: Trevor Douglas, Mark J. Young
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Patent number: 6151337Abstract: The present invention provides a means to generate a Raman-shifted output from a pump laser source. Multiple embodiments all provide a manner of producing an off-resonant, continuous wave, Raman laser by using a pump laser source having a low power. This is accomplished by using a Raman medium within a cavity having a high finesse.Type: GrantFiled: May 6, 1998Date of Patent: November 21, 2000Assignee: The Research and Development Institute, Inc.Inventors: John Carlsten, Kevin Repasky, Jason Brasseur
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Patent number: 5981264Abstract: An isolated substantially pure pseudomonas culture, exemplified by pseudomonas syringae MSU 16H (ATCC No. 67028), produces the substantially pure peptide pseudomycin which has broad spectrum anti-fungal characteristics.Type: GrantFiled: January 27, 1998Date of Patent: November 9, 1999Assignee: The Research and Development Institute, Inc. at Montana State UniversityInventors: Gary A. Strobel, Leslie A. Harrison, David B. Teplow
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Patent number: 5885791Abstract: An assay and test kit for testing and quantifying fungal inhibition by an antifungal agent. In the assay, inhibition is measured by a reduction in substrate uptake (such as glucose) as compared to uninhibited controls. A minimum inhibitory concentration value for each antifungal agent is obtained from the assay.Type: GrantFiled: November 16, 1995Date of Patent: March 23, 1999Assignees: The Research and Development Institute, Inc., The University of Virginia Patent FoundationInventors: Jim E. Cutler, Marcia H. Riesselman, Kevin C. Hazen
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Patent number: 5756095Abstract: The present invention involves monoclonal antibodies which recognize a common determinant found on separate and distinct adhesion molecules. The monoclonal antibodies are used for blocking cellular adhesion. Monoclonal antibodies are also described that are capable of binding to a common determinant expressed on separate and distinct selectins and in particular antibodies that bind to both E-selectin (also known as ELAM-1) and L-selectin (also known as LAM-I, LECAM-1, Leu-8, TQ-1, gp 90 MEL-14 and peripheral lymph node homing receptor). The monoclonal antibodies are useful in the diagnosis, treatment and prevention of diseases associated with inflammation. The monoclonal antibodies are used for detecting cells bearing selectins. Cell lines capable of producing the above described antibodies are also described.Type: GrantFiled: June 5, 1995Date of Patent: May 26, 1998Assignee: The Research and Development Institute, Inc.Inventor: Mark A. Jutila
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Patent number: 5591435Abstract: Preparations from aromatic plants that are insecticidal or are insect behaviorally active, are used to control the development of insect populations. Leaves are milled or out drying to a small average particle size. Extracts and vapors may also be used. The resultant preparation, when contacted dry commodities or structures such as books or carpets, grain bins feed/flour mills, equipment, greenhouse or ornamental plants infested storage insects or insect infested perishable produce after harvest will reduce the insect population. In addition, soil may be fumigated the extracts.Type: GrantFiled: April 25, 1994Date of Patent: January 7, 1997Assignee: The Research and Development Institute, Inc.Inventors: Florence Vaccarello-Dunkel, David K. Weaver, Theodore W. Weaver, III
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Patent number: 5578309Abstract: A composition, pharamaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannoprotein which contains adhesins from C. albicans.Type: GrantFiled: June 7, 1995Date of Patent: November 26, 1996Assignee: The Research and Development Institute, Inc.Inventors: Jim E. Cutler, Yongmoon Han
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Patent number: 5570279Abstract: PWM converters provide buck, boost, buck-boost, flyback, and Cuk configurons for three phase AC-AC power control. In an AC-DC embodiment, only a single power conversion circuit is used in a configuration including a pair of series connected gate turn off devices which are oppositely poled and oppositely timed, are connected directly to an AC input source, and provide an output to a high frequency isolating transformer. The transformer provides an output to a rectifier, which thus provides the DC output.Type: GrantFiled: September 21, 1994Date of Patent: October 29, 1996Assignee: The Research and Development Institute, Inc. at Montana State UniversityInventor: Giri Venkataramanan
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Patent number: 5343155Abstract: A system for detecting and locating faults on a power system includes the e of fault detection and transmitting devices on each pole of the system. The fault detection apparatus includes detecting coils mounted on the static line on either side of each pole, and a third detecting coil positioned so as to detect an orthogonal magnetic flux due to a phase-to-phase fault. A microprocessor on each pole analyzes the type of fault from the output of the three coils, and transmits the identification of the pole and pertinent fault data, when appropriate, to a repeater system. Thus, fault information from an entire power system can be fed through the repeater system into a central location.Type: GrantFiled: December 20, 1991Date of Patent: August 30, 1994Assignee: The Research and Development Institute, Inc. at Montana State UniversityInventors: Murari L. Kejariwal, Baldev Thapar, Victor Gerez, Daniel March
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Patent number: 5322779Abstract: Taxol is produced from a taxol-producing microorganism Taxomyces andreanae BS 279.92. Radioactive taxol products and methods for use of the radioactive labelled taxol are described.Type: GrantFiled: November 4, 1992Date of Patent: June 21, 1994Assignee: The Research and Development Institute, Inc. at Montana State UniversityInventors: Gary A. Strobel, Andrea A. Stierle, Donald B. Stierle
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Patent number: 5290408Abstract: An apparatus and method for measuring the buffering capacity of a liquid which utilizes a pH electrode positioned at the surface of a working electrode. Measured changes in pH of the metal-water interface at known potentials which are applied to the working electrode are used to calculate the liquid buffering capacity.Type: GrantFiled: August 13, 1992Date of Patent: March 1, 1994Assignee: The Research and Development Institute, Inc. at Montana State UniversityInventors: Zbigniew Lewandowski, William G. Characklis, deceased
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Patent number: 4407582Abstract: The invention provides an improved method and apparatus for reduction of matrix interference in an electrothermal atomizer for atomic absorption spectroscopy. In a carbon rod atomizer within which a sample to be analyzed is atomized to the atomic state, the graphite furnace tube is electrothermally heated from the ends to the center where the sample is located. This provides sufficient thermal energy for complete decomposition of the sample molecules to the atomic state. In a first apparatus embodiment two-pronged substantially Y-shaped graphite electrode support holders for the graphite furnace tube are provided. In a second apparatus embodiment a double-walled graphite furnace tube is provided.Type: GrantFiled: January 12, 1981Date of Patent: October 4, 1983Assignee: The Research and Development Institute, Inc. at Montana State UniversityInventor: Ray A. Woodriff