Patents Assigned to The Research & Development Institute, Inc.
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Patent number: 5821066Abstract: A rapid method for the detection, identification and enumeration of specific respiring microorganisms. The method includes steps of a) passing a microbial sample through a collecting device to capture the cells; b) adding to the collecting device a fluorochrome dye specific for the detection of respiring cells and allowing the dye to incubate; c) treating the collecting device with a reactive fluorescent antibody which reacts with a target microorganism of interest present in said microbial sample; d) mounting the collecting device for examination by fluorescence microscopy in which a suitable light system is used to excite the fluorochrome dye and fluorescent antibody to fluoresce; and e) quantifying the respiring cells. Alternative embodiments include the use of immunomagnetic beads and other means of cell capture, and employing fluorescent oligonucleotide probes rather than fluorescent antibodies.Type: GrantFiled: May 19, 1997Date of Patent: October 13, 1998Assignee: The Research & Development Institute, Inc.Inventors: Barry H. Pyle, Gordon A. McFeters
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Patent number: 5756095Abstract: The present invention involves monoclonal antibodies which recognize a common determinant found on separate and distinct adhesion molecules. The monoclonal antibodies are used for blocking cellular adhesion. Monoclonal antibodies are also described that are capable of binding to a common determinant expressed on separate and distinct selectins and in particular antibodies that bind to both E-selectin (also known as ELAM-1) and L-selectin (also known as LAM-I, LECAM-1, Leu-8, TQ-1, gp 90 MEL-14 and peripheral lymph node homing receptor). The monoclonal antibodies are useful in the diagnosis, treatment and prevention of diseases associated with inflammation. The monoclonal antibodies are used for detecting cells bearing selectins. Cell lines capable of producing the above described antibodies are also described.Type: GrantFiled: June 5, 1995Date of Patent: May 26, 1998Assignee: The Research and Development Institute, Inc.Inventor: Mark A. Jutila
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Patent number: 5591435Abstract: Preparations from aromatic plants that are insecticidal or are insect behaviorally active, are used to control the development of insect populations. Leaves are milled or out drying to a small average particle size. Extracts and vapors may also be used. The resultant preparation, when contacted dry commodities or structures such as books or carpets, grain bins feed/flour mills, equipment, greenhouse or ornamental plants infested storage insects or insect infested perishable produce after harvest will reduce the insect population. In addition, soil may be fumigated the extracts.Type: GrantFiled: April 25, 1994Date of Patent: January 7, 1997Assignee: The Research and Development Institute, Inc.Inventors: Florence Vaccarello-Dunkel, David K. Weaver, Theodore W. Weaver, III
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Patent number: 5578309Abstract: A composition, pharamaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannoprotein which contains adhesins from C. albicans.Type: GrantFiled: June 7, 1995Date of Patent: November 26, 1996Assignee: The Research and Development Institute, Inc.Inventors: Jim E. Cutler, Yongmoon Han
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Patent number: 5576298Abstract: Peptide antimycotics, termed pseudomycins, display broad spectrum antibiotic activity, and in particular are highly effective, non-toxic antibiotics against fungal pathogens of human and animal disease. The peptide antimycotics (pseudomycins) may be used in the treatment of the fungal pathogen Candida albicans. Also disclosed is a method of purification and isolation, including characterization, of the pseudomycins.Type: GrantFiled: September 15, 1994Date of Patent: November 19, 1996Assignee: Research and Development Institute, Inc. at Montana State UniversityInventors: Gary A. Strobel, Leslie A. Harrison, David B. Teplow
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Patent number: 5570279Abstract: PWM converters provide buck, boost, buck-boost, flyback, and Cuk configurons for three phase AC-AC power control. In an AC-DC embodiment, only a single power conversion circuit is used in a configuration including a pair of series connected gate turn off devices which are oppositely poled and oppositely timed, are connected directly to an AC input source, and provide an output to a high frequency isolating transformer. The transformer provides an output to a rectifier, which thus provides the DC output.Type: GrantFiled: September 21, 1994Date of Patent: October 29, 1996Assignee: The Research and Development Institute, Inc. at Montana State UniversityInventor: Giri Venkataramanan
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Patent number: 5538890Abstract: A broad spectrum biological herbicide comprises a mammal-sparing bioherbicide fungal mutant, e.g., a S. sclerotiorum mutant, of limited survival time and geographical dissemination characteristics under standard agricultural conditions. The invention also relates to a method of obtaining herbicides of the invention comprising obtaining viable wild type bioherbicide fungal spores, subjecting these to UV light to reduce the number of viable fungi to less than 5% the initial number of spores, selecting mutants which differ from the wild type in at least one characteristic such as altered phenotype or morphology, and further selecting a mammal-sparing bioherbicide fungal mutant of reduced survival time and geographical dissemination characteristics under agricultural conditions when compared with the wild type. The invention also relates to a method of using the broad spectrum biological herbicide to reduce the number of weeds in an area.Type: GrantFiled: August 13, 1992Date of Patent: July 23, 1996Assignee: Research and Development Institute, Inc. at Montana State UniversityInventors: David C. Sands, Roger V. Miller, Eugene Ford, Gregory Kennett
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Patent number: 5419887Abstract: The isotopes of boron, .sup.10 B and .sup.11 B, are separated by means of a gas-liquid chemical exchange reaction involving the isotopic equilibrium between gaseous BF.sub.3 and a liquid BF.sub.3 . donor molecular addition complex formed between BF.sub.3 gas and a donor chosen from the group consisting of: nitromethane, acetone, methyl isobutyl ketone, or diisobutyl ketone.Type: GrantFiled: January 25, 1994Date of Patent: May 30, 1995Assignee: Research & Development Institute, Inc.Inventors: Frank P. McCandless, Ronald S. Herbst
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Patent number: 5343155Abstract: A system for detecting and locating faults on a power system includes the e of fault detection and transmitting devices on each pole of the system. The fault detection apparatus includes detecting coils mounted on the static line on either side of each pole, and a third detecting coil positioned so as to detect an orthogonal magnetic flux due to a phase-to-phase fault. A microprocessor on each pole analyzes the type of fault from the output of the three coils, and transmits the identification of the pole and pertinent fault data, when appropriate, to a repeater system. Thus, fault information from an entire power system can be fed through the repeater system into a central location.Type: GrantFiled: December 20, 1991Date of Patent: August 30, 1994Assignee: The Research and Development Institute, Inc. at Montana State UniversityInventors: Murari L. Kejariwal, Baldev Thapar, Victor Gerez, Daniel March
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Patent number: 5322779Abstract: Taxol is produced from a taxol-producing microorganism Taxomyces andreanae BS 279.92. Radioactive taxol products and methods for use of the radioactive labelled taxol are described.Type: GrantFiled: November 4, 1992Date of Patent: June 21, 1994Assignee: The Research and Development Institute, Inc. at Montana State UniversityInventors: Gary A. Strobel, Andrea A. Stierle, Donald B. Stierle
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Patent number: 5306497Abstract: Preparations from aromatic plants that are insecticidal or are insect behaviorally active, are used to control the development of insect populations. The plants are harvested after leaf maturation. Leaves are removed in a random pattern both as to individual plants and to location of leaves on each plant. The collection includes petioles but not stems. Leaves are milled with or without drying to a small average particle size. Extracts and vapors may also be used. The resultant preparation, when contacted with dry commodities infested with storage insects or with insect infested perishable produce after harvest will reduce the insect population.Type: GrantFiled: December 6, 1991Date of Patent: April 26, 1994Assignee: Research and Development Institute Inc. at Montana State UniversityInventors: Florence V. Dunkel, David K. Weaver, Weaver, III: Theodore W.
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Patent number: 5290408Abstract: An apparatus and method for measuring the buffering capacity of a liquid which utilizes a pH electrode positioned at the surface of a working electrode. Measured changes in pH of the metal-water interface at known potentials which are applied to the working electrode are used to calculate the liquid buffering capacity.Type: GrantFiled: August 13, 1992Date of Patent: March 1, 1994Assignee: The Research and Development Institute, Inc. at Montana State UniversityInventors: Zbigniew Lewandowski, William G. Characklis, deceased
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Patent number: 5139640Abstract: An apparatus and method for measuring the buffering capacity of a fluid which utilizes a pH electrode that is positioned at the surface of a smooth metal working electrode. Measured changes in pH of the metal-water interface at known potentials which are applied to the working electrode are used to calculate the fluid buffering capacity.Type: GrantFiled: December 19, 1990Date of Patent: August 18, 1992Assignee: Research and Development Institute, Inc. at Montana State UniversityInventors: Zbignjew Lewandowski, William G. Characklis
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Patent number: 4981105Abstract: DL-methionine is fed to a ruminant animal in slow release form so as to stimulate protein growth in the first stomach or rumen and thus control growth of the animal.Type: GrantFiled: October 16, 1989Date of Patent: January 1, 1991Assignee: Research and Development Institute, Inc. at Montana State UniversityInventor: Mark K. Petersen
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Patent number: 4929270Abstract: A method of selectively inducing chlorosis on a knapweed plant while spar other plants comprises applying a knapweed phytotoxic amount of the L,L isomer of the cyclodipeptide of the invention to a field at a period in time prior, during or subsequent to the emergence of the plants; and allowing for the cyclodipeptide to remain in contact with the plants for a period of time effective to attain the phytotoxic effect.Type: GrantFiled: April 4, 1988Date of Patent: May 29, 1990Assignee: Research and Development Institute, Inc. at Montana State UniversityInventors: John H. Cardellina, II, Andrea C. Stierle, Gary A. Strobel
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Patent number: 4912332Abstract: A non-destructive method for the early detection of the formation of orga deposits or a biofilm on the internal surface of a conduit through which a fluid passes comprises allowing the fluid to flow through a conduit, passing a light beam, e.g., IR or UV light, through the fluid and the deposits in a direction transversal to the surface thereof, detecting and measuring the transmitted portion of the light beam after it has emerged from the fluid and the deposits, conducting these measurements at least twice at a set time interval, the first time before any materials deposit, and calculating % variation absorbed light during the time interval, which value is proportional to the organic materials or biofilm deposited and a method of removing at least a portion of organic deposits or a biofilm deposited on the internal surface of a conduit through which a fluid flows comprises allowing the fluid to flow through a conduit having a deposited organic layer or biofilm, passing a light beam, e.g.Type: GrantFiled: June 3, 1988Date of Patent: March 27, 1990Assignee: Research and Development Institute, Inc. at Montana State UniversityInventors: Maarten A. Siebel, William G. Characklis, Rune Bakke
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Patent number: 4897350Abstract: Mutant microorganisms comprising Lactobacillus fermentum Lex.sup.+ which are obtained from Lactobacillus fermentum produce lysine in a significantly greater quantity than the wildtype microorganism. The microorganism is added to a sourdough starter to produce bread of increased nutritive content, such as flat bread. Freeze-dried cultures of the microorganism may be added to cereal grains such as wheat in bulk to increase the basic nutritive protein quality of the wheat, whereby foodstuffs produced from the cereal grains have increased protein values. Cultures of the microorganisms in admixture with yeast may be used as a bread starter.Type: GrantFiled: January 30, 1986Date of Patent: January 30, 1990Assignee: Research and Development Institute, Inc. at Montana State Univeristy of Bozeman MontanaInventors: Mohamed E. A. El-Megeed, David C. Sands
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Patent number: 4889810Abstract: Mutant microorganisms comprising Lactobacillus ferementum Lex.sup.+ which are obtained from Lactobacillus fermentum produce lysine in a significantly greater quantity than the wildtype microorganism. The microorganism is added to a sourdough starter to produce bread of increased nutritive content, such as flat bread. Freeze-dried cultures of the microorganism may be added to cereal grains such as wheat in bulk to increase the basic nutritive protein quality of the wheat, whereby foodstuffs produced from the cereal grains have increased protein values.Type: GrantFiled: February 13, 1985Date of Patent: December 26, 1989Assignee: Research and Development Institute, Inc. at Montana State UniversityInventors: Mohamed E. A. El-Megeed, David C. Sands
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Patent number: 4588693Abstract: Beneficial growth of roots in dicotyledonous plants is achieved by genetic transformation with root-inducing A. rhizogenes, preferably the novel strain A. rhizogenes ATCC 39207. The A. rhizogenes not used to transform the plant is reduced to noninfective levels with A. radiobacter, preferably A. radiobacter K-84.Type: GrantFiled: February 28, 1983Date of Patent: May 13, 1986Assignee: Research and Development Institute, Inc. at Montana State UniversityInventor: Gary A. Strobel
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Patent number: 4517008Abstract: A novel agriculturally useful composition that includes a seed treated with selected infectivity-cured Hr plasmid-bearing microorganism. Also provided are methods of enhancing root elongation, shoot elongation or root development of selected seeds. These methods include treating a selected seed with the infectivity-cured Hr plasmid-bearing microorganism. In addition, there is provided a method of inducing germination of grass seed that involves treating a grass seed such as Kentucky bluegrass seed with a selected infectivity-cured Hr plasmid-bearing microorganism. Furthermore, there is provided a method of promoting plant growth at a lower soil temperature than is common at the time of planting a seed of the plant. Additionally, there is disclosed an inoculant for increasing nodulation, root mass and shoot mass in a leguminous plant. The inoculant contains a Rhizobium microorganism and a selected infectivity-cured Hr plasmid-bearing microorganism.Type: GrantFiled: June 16, 1982Date of Patent: May 14, 1985Assignee: Research and Development Institute, Inc. at Montana State UniversityInventors: Gary A. Strobel, Andrea H. Gavlak, Jesse M. Jaynes