Abstract: The present invention provides a compound having the structure: wherein R1 is H or a protecting group; R2 and R3 are each independently H, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkyl-C(O)NHR6, C1-C6 alkyl-C(O)OR6, wherein R6 is H, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl, or R2 and R3 combine to form a 3-7 membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring; and R4 and R5 are each independently halo.

Abstract: The present disclosure relates to processes for preparing functionalized cyclooctenes and the synthetic intermediates prepared thereby.

Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.

Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.

Abstract: A method for controlling a data center, comprising a plurality of server systems, each associated with a cooling system and a thermal constraint, comprising: a concurrent physical condition of a first server system; predicting a future physical condition based on a set of future states of the first server system; dynamically controlling the cooling system in response to at least the input and the predicted future physical condition, to selectively cool the first server system sufficient to meet the predetermined thermal constraint; and controlling an allocation of tasks between the plurality of server systems to selectively load the first server system within the predetermined thermal constraint and selectively idle a second server system, wherein the idle second server system can be recruited to accept tasks when allocated to it, and wherein the cooling system associated with the idle second server system is selectively operated in a low power consumption state.

Abstract: A quantum-key distributed (QKD)-enabled communication architecture it devises for networked microgrids (NMGs). A real-time QKD-enabled NMGs testbed built in an RTDS environment, and a novel two-level key pool sharing (TLKPS) strategy it designs to improve the system resilience against cyberattacks. In the QKD-based microgrid testbed design there is used a real-time power system simulator, i.e., RTDS, including the QKD modeling, hardware connection, communication network design, and QKD integration. By integrating QKD features into a real-time microgrid simulator, this testbed offers a flexible and programmable testing environment for evaluating the performance of QKD-enabled microgrids under a variety of scenarios.

Abstract: A surgical system is provided. The surgical system includes a camera operable to capture images and/or video. A projector is operable to project light, and a controller is communicatively coupled with the camera and the projector. The controller is operable to track movement of bone in real-time during surgery based on the images and/or video captured by the camera, and control the projector to project the light including a cutting line on the bone to indicate a cutting plane for cutting the bone during surgery.

Abstract: The disclosure provides methods of treating a condition of the retina by administering an inhibitor of connexin 36 and/or an inhibitor of connexin 45 to a subject with a retinal condition. This disclosure further provides compositions for the treatment of a retinal condition which include an inhibitor of connexin 36 and/or an inhibitor of connexin 45.

Abstract: Quantum network devices, systems, and methods are provided to enable long-distance transmission of quantum bits (qubits) for applications such as Quantum Key Distribution (QKD), entanglement distribution, and other quantum communication applications. Such systems and methods provide for separately storing first, second, third, and fourth photons, wherein the first and second photons and the third and fourth photons are respective first and second entangled photon pairs, triggering a synchronized retrieval of the stored first, second, third, and fourth photons such that the first photon is propagated to a first node, the second and third photons are propagated to a second node, and the fourth photon is propagated to a third node, and creating a new entangled pair comprising the first and fourth photons at the first and third nodes to transmit quantum information.

Abstract: A sensor including a layer of amorphous selenium (a-Se) and at least one charge blocking layer is formed by depositing the charge blocking layer over a substrate prior to depositing the amorphous selenium, enabling the charge blocking layer to be formed at elevated temperatures. Such a process is not limited by the crystallization temperature of a-Se, resulting in the formation of an efficient charge blocking layer, which enables improved signal amplification of the resulting device. The sensor can be fabricated by forming first and second amorphous selenium layers over separate substrates, and then fusing the a-Se layers at a relatively low temperature.

Abstract: A system and method for controlling a system, comprising estimating an optimal control policy for the system; receiving data representing sequential states and associated trajectories of the system, comprising off-policy states and associated off-policy trajectories; improving the estimate of the optimal control policy by performing at least one approximate value iteration, comprising: estimating a value of operation of the system dependent on the estimated optimal control policy; using a complex return of the received data, biased by the off-policy states, to determine a bound dependent on at least the off-policy trajectories, and using the bound to improve the estimate of the value of operation of the system according to the estimated optimal control policy; and updating the estimate of the optimimal control policy, dependent on the improved estimate of the value of operation of the system.

Abstract: Operations of radiometers may be improved by calculating calibration uncertainties for the radiometer. Initially, operational characteristics for the radiometer, and/or historical calibration parameters for a plurality of previously performed calibration processes using the radiometer may be obtained. Additionally, a calibration uncertainty for the radiometer based on the obtained operational characteristics for the radiometer and the obtained historical calibration parameters may be calculated, and desired, calibration parameters for the radiometer may be identified. The identified desired, calibration parameters may be based on the calculated, calibration uncertainty.

Abstract: Compositions and methods for the treatment of malignancy are disclosed.

Abstract: Handheld, broadband terahertz (THz) scanners, housings therefor and imaging systems are provided. The scanner may comprise a 2-Dimensional (2D) gimbaled mirror for beam steering. The 2D gimbaled mirror may comprise a single mirror mounted in a frame, a first motor and a second motor. The first motor and the second motor may be coupled to the frame. The mirror may be rotatable in a first axis of rotation and a second axis of rotation to scan light on a target in two dimensions. The first motor corresponds to the first axis and the second motor corresponding to the second axis. The 2D gimbaled mirror may be positioned within the housing such that the single mirror is positioned at a focus of a focusing lens. The focusing lens may be fixed within a housing. The scanner may also comprise a terahertz emitter and detector.

Abstract: Provided is provided is a compound of Formula I and a method of forming a tagged 2-thiouridine tRNA by contacting it with a compound of Formula I, wherein the compound may include a label such as a fluorescent label. Also provided is a method of forming a tagged RNA, comprising contacting a prenylated tRNA or an N6-isopentenyladenosine-prenylated RNA with a 4-phenyl-1,2,4-triazoline-3,5-dione activated fluorescence label. Also provided is a method of sequencing a polyribonucleotide comprising a prenyl group.

Abstract: Systems for performing ON-OFF perimetry visual field tests. The systems may include a display apparatus including at least one display, and at least one computing device in electronic communication with the display apparatus. The computing device(s) may be configured to perform the ON-OFF perimetry test on a patient by performing processes including directing the patient to visual focus on an eye fixation region depicted in a visual field. The visual field may be divided into a right side and a left side. The processes performed by the computing device(s) may also include generating a plurality of stimuli in the visual field to be detected by the patient, directing the patient to indicate when the patient detects each stimulus depicted within the visual field, and analyzing the patient's indications to diagnosis a retinal disease, a visual cortex disease, and/or a deficit condition of an eye of the patient.

Abstract: A method of fabricating nanocomposite anode material embodying a lithium titanate (LTO)-multi-walled carbon nanotube (MWNT) composite intended for use in a lithium-ion battery includes providing multi-walled carbon nanotube (MWNTs), including nanotube surfaces, onto which functional oxygenated carboxylic acid moieties are arranged, generating 3D flower-like, lithium titanate (LTO) microspheres, including thin nanosheets and anchoring the acid-functionalized MWNTs onto surfaces of the 3D LTO microspheres by ?-? interaction strategy to realize the nanocomposite anode material.

Abstract: A system and method of scheduling tasks, comprising receiving activity and performance data from registers or storage locations maintained by hardware and an operating system; storing calibration coefficients associated with the activity and performance data; computing an energy dissipation rate based on at least the activity and performance data; and scheduling tasks under the operating system based on the computed energy dissipation rate.

Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.

Abstract: A technique to additively print onto a dissimilar material, especially ceramics and glasses (e.g., semiconductors, graphite, diamond, other metals) is disclosed herein. The technique enables manufacture of heat removal devices and other deposited structures, especially on heat sensitive substrates. It also enables novel composites through additive manufacturing. The process enables rapid bonding, orders-of-magnitude faster than conventional techniques.