Abstract: System and method to improve the linearity of vector matrix multipliers (VMMs) by including (1) delta-sigma modulators that convert the input and output activations into binary pulse trains, (2) charge-domain computation in each SRAM cell that removes the nonlinear dependency on bitline voltage of the result of the multiplication and allows rail-to-rail output swing, and (3) a CMOS switch that transmits input activation to the capacitor in the SRAM cell, which improves linearity by suppressing the switch threshold voltage dependence on input activation voltage.
Type:
Application
Filed:
April 17, 2024
Publication date:
October 24, 2024
Applicants:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, THE RESEARCH FOUNDATION FOR THE STATE UNIVERISTY OF NEW YORK
Inventors:
Arindam SANYAL, Jae-sun SEO, Vasundhara DAMODARAN, Ziyu LIU
Abstract: Provided is a method of inhibiting protein kinase C zeta/protein kinase M zeta, including contacting a sample containing an isoform of protein kinase C zeta with a compound of formula: referred to as 1-naphthol-3,6,8-trisulphonic acid, or a pharmaceutically acceptable salt thereof. In some embodiments, contacting the sample with the compound does not inhibit protein kinase C iota/lambda. In a specific example, the sample includes neural tissue, the isoform of protein kinase C zeta is protein kinase M zeta, and inhibiting includes reducing kinase activity and further includes diminishing long-term potentiation. In some embodiment, the method includes inhibiting glucose transport. Also provided is a method of affecting memory, including administering the compounds to a mammalian organism.
Type:
Grant
Filed:
October 15, 2018
Date of Patent:
September 20, 2022
Assignees:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERISTY OF NEW YORK, UNIVERSITY OF SOUTH FLORIDA
Abstract: Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning.
Type:
Grant
Filed:
April 24, 2018
Date of Patent:
August 20, 2019
Assignees:
The United States of America, as Represented by the Secretary, Department of Health and Human Services, The Research Foundation of the State Univeristy of New York
Inventors:
Peter R. Williamson, Dale O. Kiesewetter, John Panepinto, Jin Qiu
Abstract: Pillared interlayered clay catalysts (PILC) are formed and used in the selective reduction (SCR) of nitrogen oxides (NO.sub.x) in exhaust gases in the presence of ammonia. Cr.sub.2 O.sub.3 -PILC, Fe.sub.2 O.sub.3 PILC, TiO.sub.2 -PILC, ZrO.sub.2 -PILC and Al.sub.2 O.sub.3 -PILC each have considerable activities in the SCR of NO by NH.sub.3. Forming the catalysts in a bimodal pore structure provides increases poison resistance and increases reaction rates. Doping the catalyst with CeO.sub.2 and/or Ce.sub.2 O.sub.3 can promote increased activities. The PILC SCR catalysts do not oxidize SO.sub.2 to undesirable SO.sub.3 in any detectable amount.
Type:
Grant
Filed:
February 24, 1993
Date of Patent:
May 16, 1995
Assignees:
The Research Foundation of State Univeristy of New York, Electric Power Research Institute
Abstract: Biological applications of synthetic and natural alkaloids derived from the tunicate Eudistoma sp. are disclosed. A method regulating cell growth includes contacting one or more cells with an effective concentration of a compound for regulating cell growth. These compounds include: Segoline A, Segoline B, Isosegoline A, Norosegoline, Debromoshermilamine, Eilatin, 4-methylpyrido[2,3,4-kl] acridine, pyrido[2,3,4-kl]acridine, 1-acetyl-2,6-dimethylpyrido[2,3,4-kl]acridine, and derivatives and combinations of these compounds. An effective concentration range for using these compounds can range from approximately 0.1 .mu.M to 100 .mu.M. The effective concentration range for Eilatin, the most potent of these compounds is from 0.01 .mu.M to 0.99 .mu.M, and the effective concentration range for the other compounds of the present invention is from about 1.0 .mu.M to 100 .mu.M.
Type:
Grant
Filed:
August 3, 1992
Date of Patent:
January 11, 1994
Assignee:
The Research Foundation of State Univeristy of New York
Inventors:
Ilan Spector, Nava R. Shochet, Yoel Kashman, Amira Rudi