Patents Assigned to The Research Foundation of State University
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Patent number: 11549101Abstract: This invention provides highly attenuated influenza viruses and vaccines. The attenuated viruses and vaccines proliferate well and have high safety factors. The attenuated viruses providing protective immunity from challenge by virus of the same subtype, as well as cross protection against heterologous viruses.Type: GrantFiled: June 10, 2019Date of Patent: January 10, 2023Assignee: The Research Foundation for State University of New YorkInventors: Steffen Mueller, Eckard Wimmer, Bruce Futcher, Steven Skiena, Chen Yang
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Patent number: 11305000Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.Type: GrantFiled: January 19, 2018Date of Patent: April 19, 2022Assignees: Brookhaven Science Associates, LLC, The Research Foundation of State University of New York, Baxalta Incorporated, Baxalta GmbHInventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
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Patent number: 11259740Abstract: The present invention pertains to methods of determining where, on the skin, a diagnostic, therapeutic, or cosmetic agent is likely to be most effectively applied (e.g., injected), and to methods for monitoring a patient after such an agent has been administered. The monitoring can produce information useful in determining whether a diagnostic, therapeutic (e.g., surgical), or cosmetic regime should be initiated, continued, continued in a modified fashion, or terminated (e.g., for a brief or prolonged period of time). The methods can be repeated periodically and use a non-invasive, in vivo form of digital image speckle correlation (DISC) to track deformation of the skin.Type: GrantFiled: April 3, 2018Date of Patent: March 1, 2022Assignee: The Research Foundation for State University of New YorkInventors: Divya Bhatnagar, Miriam Rafailovich, Raphael Davis, Alexander B. Dagum, Duc T. Bui
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Patent number: 11226082Abstract: An optoelectronic light source includes a semiconductor laser configured to produce polarized primary radiation, a converter material configured to absorb at least part of the primary radiation and convert the primary radiation into a secondary radiation of an increased wavelength, a planar multi-layered mirror located between the semiconductor laser and the converter material, the multi-layered mirror configured to transmit the primary radiation and reflect the secondary radiation, and an optical element provided between the semiconductor laser and the multi-layered mirror, wherein the optical element is configured such that the primary radiation coming from the semiconductor laser impinges on the multi-layered mirror at a Brewster angle.Type: GrantFiled: August 13, 2020Date of Patent: January 18, 2022Assignees: OSRAM Opto Semiconductors GmbH, The Research Foundation for State University of New YorkInventors: Alan Lenef, David Klotzkin, Xin Wen
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Patent number: 10814146Abstract: A method for delivering therapeutic radiation to a target includes positioning a multi-aperture collimator on the skin within a trajectory of orthovoltage x-rays directed at the target, thus generating an array of minibeams, each of width between 0.1 mm to 0.6 mm. The skin is irradiated with the array. An effective beam of therapeutic radiation, which may be a solid beam, is delivered to the target at a predetermined tissue depth by merging adjacent orthovoltage x-ray minibeams sufficiently to form the effective beam. The effective beam may be formed proximal to the target. The depth at which the effective, preferably, solid, beam is formed is controlled by varying one or more of the spacing of the minibeams in the array, the minibeam width, the distance from the x-ray source to the collimator, and the x-ray source spot size. Planar minibeams can be arc-scanned while continuously modulating beam shape and intensity.Type: GrantFiled: September 26, 2018Date of Patent: October 27, 2020Assignees: The Research Foundation for State University of New York, The Board of Regents, The University of Texas SystemInventors: F. Avraham Dilmanian, Sunil Krishnan, John Gordon Eley
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Patent number: 10808893Abstract: An optoelectronic semiconductor light source includes a semiconductor chip configured to emit primary radiation, a Bragg mirror, and a luminescence conversion element configured to convert at least part of the primary radiation into secondary radiation having a longer wavelength, wherein the Bragg mirror is arranged between the semiconductor chip and the luminescence conversion element, the Bragg mirror is reflective for the secondary radiation and transmissive for the primary radiation, the Bragg mirror includes reflector layers of at least three different materials with different refractive indices, the Bragg mirror includes at least two different kinds of layer pairs, each kind of layer pairs being made up of reflective layers of two different materials, and the different kinds of layer pairs having different Brewster angles for p-polarized radiation.Type: GrantFiled: March 4, 2019Date of Patent: October 20, 2020Assignees: OSRAM Opto Semiconductors GmbH, The Research Foundation For State University of New YorkInventors: Alan Lenef, David Klotzkin, Xin Wen
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Patent number: 10760016Abstract: A gasifier system includes a reactor for receiving a wet feedstock which has a base and a container rotatably connected to the base such that a rotation of the container causes a mixing of the feedstock in an interior of the reactor. The interior is bounded by the base and the container. A space between the base and the container allows an entry of oxygen into the interior. The space has a dimension such that the feedstock is fully oxidized in a combustion area adjacent the base and such that the feedstock avoids combustion in a remainder of the interior. The reactor has a longitudinal axis inclined at an inclination angle relative to a horizontal line to promote the mixing of the feedstock in the interior.Type: GrantFiled: April 21, 2015Date of Patent: September 1, 2020Assignee: The Research Foundation of State University of New YorkInventor: David J. Waage
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Patent number: 10492717Abstract: A method includes receiving multiple compound muscle action potential values (CMAPs), wherein each CMAP is an onset latency, a peak latency, a conduction velocity, or a response amplitude measured from a baseline; for each of the CMAPs and for each of a number parameters calculated from the CMAPs, determining a corresponding demyelinating boundary value using a normal value from a preselected population; determining whether each of the CMAPs and each of the parameters exceeds the corresponding demyelinating boundary value; determining one or more demyelinated nerve pathways based on which of the CMAPs and the parameters exceeds the corresponding demyelinating boundary value; indicating on a display which of the CMAPs and the parameters exceed the corresponding demyelinating boundary value; and displaying, in pictorial form, an anatomical diagram indicating the demyelinated nerve pathways.Type: GrantFiled: November 4, 2014Date of Patent: December 3, 2019Assignee: The Research Foundation of State University of New YorkInventors: Paul Jacob Maccabee, Lawrence Philip Eberle
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Patent number: 10393690Abstract: A flexible chemiresistor (CR) sensor for sensing a molecule of interest in a fluid (liquid or gas) is provided. The flexible CR sensor comprises a flexible chemiresistor (CR) module. The flexible CR module comprises a flexible substrate such polyethylene terephthalate (PET), polyethylene naphthalate (PEN) or polyimide (PI), and a thin film nanoparticle assembly assembled on the flexible substrate. The thin film nanoparticle assembly comprises metal or metal alloy core, ligand-capped nanoparticles and molecular linkers connecting the nanoparticles. The flexible CR sensor and an intelligent pattern recognition engine can be incorporated in a handheld device that can detect a molecule of interest in a fluid (e.g., a liquid or gas) accurately, rapidly, and without false positives. Any sensing array nanomaterial, pattern recognition, and compact/or electronic hardware can be integrated to achieve a desired detection limit and response speed.Type: GrantFiled: April 21, 2017Date of Patent: August 27, 2019Assignee: The Research Foundation of State University of New YorkInventors: Chuan-Jian Zhong, Jin Luo, Lingyan Wang
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Patent number: 10234455Abstract: Compositions and methods for diagnosing an increased risk of NPSLE are provided.Type: GrantFiled: October 10, 2017Date of Patent: March 19, 2019Assignee: The Research Foundation for State University of New YorkInventors: Henri Tiedge, Anna Iacoangeli
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Patent number: 10124194Abstract: A method for delivering therapeutic radiation to a target includes positioning a multi-aperture collimator on the skin within a trajectory of orthovoltage x-rays directed at the target, thus generating an array of minibeams, each of width between 0.1 mm to 0.6 mm. The skin is irradiated with the array. An effective beam of therapeutic radiation, which may be a solid beam, is delivered to the target at a predetermined tissue depth by merging adjacent orthovoltage x-ray minibeams sufficiently to form the effective beam. The effective beam may be formed proximal to the target. The depth at which the effective, preferably, solid, beam is formed is controlled by varying one or more of the spacing of the minibeams in the array, the minibeam width, the distance from the x-ray source to the collimator, and the x-ray source spot size. Planar minibeams can be arc-scanned while continuously modulating beam shape and intensity.Type: GrantFiled: June 21, 2016Date of Patent: November 13, 2018Assignees: The Research Foundation for State University of New York, The Board of Regents, The University of Texas SystemInventors: F. Avraham Dilmanian, Sunil Krishnan, John Gordon Eley
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Patent number: 10064554Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.Type: GrantFiled: December 14, 2012Date of Patent: September 4, 2018Assignees: The Trustees of the University of Pennsylvania, The Research Foundation of State University of New YorkInventors: Thomas F. Floyd, Arjun G Yodh, Rickson C. Mesquita
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Patent number: 9968271Abstract: A needle electrode is provided incorporating a protective flap and optionally a retraction chamber. By providing an impenetrable barrier covering the area of skin over the needle's tip, the protective flap protects against needle sticks that can occur when the tip of a needle electrode is pushed back out through the skin. An adhesive layer on the skin-side of the protective flap secures the needle in place without the use of a separate piece of adhesive tape. Other types of needles can incorporate flaps for protection or for securing the needle to the patient.Type: GrantFiled: February 28, 2013Date of Patent: May 15, 2018Assignee: The Research Foundation of State University of New YorkInventors: David J. Padalino, Blair Calancie
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Patent number: 9945863Abstract: Methods for diagnosing and treating a cancer or a tumor in a patient are provided. The methods can comprise the steps of obtaining a biological sample from the patient and analyzing the sample for the presence or absence of Coiled Coil Helix Cristae Morphology 1 protein (CHCM1). A patient is diagnosed with cancer or a tumor provided that CHCM1 is overexpressed. The diagnosed patient is treated by administering a cancer or tumor treatment. The methods can also comprise the steps of obtaining a sample of cancer or tumor cells from the patient, determining a level of CHCM1 expression in the sample of cancer or tumor cells, and administering to the patient a compound for reducing the expression of CHCM1 or for blocking or inhibiting function of CHCM1.Type: GrantFiled: December 16, 2013Date of Patent: April 17, 2018Assignee: The Research Foundation of State University of New YorkInventors: M. Saeed Sheikh, Ying Huang, Jie An
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Patent number: 9920220Abstract: Embodiments of films and material layers comprising PEDOT. These embodiments are the result of methods that utilize polymerization processes including vapor phase polymerization (VPP) to form the conductive film comprising PEDOT. In one embodiment, the film can result from a method that includes steps for depositing a coating solution onto a substrate, exposing the substrate to a monomer source, and cleaning the substrate after polymerization. The coating solution can comprise an initiating oxidant, which facilitates growth of PEDOT from 3,4 ethylenedioxythiophene (EDOT), as well as a quenching agent that neutralizes acid that results from polymerization.Type: GrantFiled: March 14, 2014Date of Patent: March 20, 2018Assignee: The Research Foundation of State University of New YorkInventors: William E. Bernier, Nicholas A. Ravvin, Wayne E. Jones, Jr., Kenneth H. Skorenko
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Patent number: 9784739Abstract: Compositions and methods for diagnosing an increased risk of NPSLE are provided.Type: GrantFiled: November 10, 2015Date of Patent: October 10, 2017Assignee: The Research Foundation for State University of New YorkInventors: Henri Tiedge, Anna Iacoangeli
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Patent number: 9777334Abstract: Compositions and methods for diagnosing an increased risk for the development of aggressive, invasive breast cancer are provided.Type: GrantFiled: March 14, 2013Date of Patent: October 3, 2017Assignee: The Research Foundation for State University of New YorkInventors: Henri Tiedge, Anna Iacoangeli, Gerald A. Soff
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Patent number: 9636424Abstract: The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue.Type: GrantFiled: May 19, 2016Date of Patent: May 2, 2017Assignees: The Research Foundation of State University of New York, University of ConnecticutInventors: Arkady M. Pertsov, Arvydas Matiukas, Leslie M. Loew, Joseph P. Wuskell
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Patent number: 9632050Abstract: A flexible chemiresistor (CR) sensor for sensing a molecule of interest in a fluid (liquid or gas) is provided. The flexible CR sensor comprises a flexible chemiresistor (CR) module. The flexible CR module comprises a flexible substrate such polyethylene terephthalate (PET), polyethylene naphthalate (PEN) or polyimide (PI), and a thin film nanoparticle assembly assembled on the flexible substrate. The thin film nanoparticle assembly comprises metal or metal alloy core, ligand-capped nanoparticles and molecular linkers connecting the nanoparticles. The flexible CR sensor and an intelligent pattern recognition engine can be incorporated in a handheld device that can detect a molecule of interest in a fluid (e.g., a liquid or gas) accurately, rapidly, and without false positives. Any sensing array nanomaterial, pattern recognition, and compact/or electronic hardware can be integrated to achieve a desired detection limit and response speed.Type: GrantFiled: July 13, 2015Date of Patent: April 25, 2017Assignee: The Research Foundation for State University of New YorkInventors: Chuan-Jian Zhong, Jin Luo, Lingyan Wang
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Patent number: 9548501Abstract: A supported catalyst is prepared by a process that includes establishing shell-removal conditions for a supported catalyst intermediate that includes capped nanoparticles of a catalyst material dispersed on a carbon support. The capped nanoparticles each include a platinum alloy core capped in an organic shell. The shell-removal conditions include an elevated temperature and an inert gas atmosphere that is substantially free of oxygen. The organic shell is removed from the platinum alloy core under the shell-removal conditions to limit thermal decomposition of the carbon support and thereby limit agglomeration of the catalyst material such that the supported catalyst includes an electrochemical surface area of at least 30 m2/gPt.Type: GrantFiled: December 17, 2009Date of Patent: January 17, 2017Assignees: The Research Foundation of State University Of New York Research Development Services, Binghamton University, Toyoata Jidosha Kabushiki Kaisha, Audi AGInventors: Chuan-Jian Zhong, Brigid Wanjala, Jin Luo, Peter N. Njoki, Rameshwori Loukrakpam, Minhua Shao, Lesia V. Protsailo, Tetsuo Kawamura