Patents Assigned to The Research Foundation of State University of New York
  • Compositions and methods comprising permuted protein tags for facilitating overexpression, solubility, and purification of target proteins
    Patent number: 11401520
    Abstract: Provided are compositions and methods for used in solubilizing, stabilizing and expressing proteins. The proteins are fusion proteins that contain a protein of interest. The fusion proteins contain segments of Ribose Binding Protein (RBP) or Maltose Binding Protein (MBP). The fusion proteins can have the RBP or MBP segments flanking the target protein, and the RBP or MBP segments can be in the fusion protein in the same orientation as they normally occur (except for being interrupted by the target protein) or the segments can be permuted. Novel segments of the RBP and MBP are provided and result in improved expression and/or solubility of the proteins. Some examples include one or a combination of two complete or partial Histidine tags. Some examples allow for the target protein to be separated from all or a part of the fusion protein such as by enzymatic or non-enzymatic cleavage.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: August 2, 2022
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Stewart N. Loh, Jeung-Hoi Ha
  • Solderless circuit connector
    Patent number: 11404805
    Abstract: A device is provided that allows for repeated electrical connection of an integrated circuit. The device includes a top, an alignment plate, a connector and a bottom. The top, alignment plate, connector and bottom each have first and second sides facing opposite directions, with the top, alignment plate, connector and bottom being stacked in a vertical orientation. The top is vertically moveable relative to the alignment plate to secure the integrated circuit adjacent to an edge of the connector, with the edge extending from a space between the first and second sides thereof.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: August 2, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: Anatoliy Borodin, Yuri Polyakov
  • INHIBITORS OF ADENYLATE-FORMING ENZYME MENE
    Publication number: 20220235088
    Abstract: Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts or tautomers thereof which may inhibit adenylate-forming enzymes. Also provided are pharmaceutical compositions, kits, uses, and methods involving the inventive compounds for the treatment and/or prevention of an infectious disease (e.g., bacterial infection (e.g., tuberculosis, methicillin-resistant Staphylococcus aureus)).
    Type: Application
    Filed: February 7, 2020
    Publication date: July 28, 2022
    Applicants: Memorial Sloan-Kettering Cancer Center, The Research Foundation for The State University of New York
    Inventors: Derek Shieh Tan, Christopher E. Evans, Peter J. Tonge, Melissa Lynn Boby, Yuanyuan Si
  • METHOD AND DEVICE FOR PARALLEL SINGLE-CELL PROCESSING
    Publication number: 20220226815
    Abstract: The present disclosure is directed to a microwell array comprising a plurality of wells of micro-size dimensions created on porous materials. The device can be used in various cell and tissue analytical activities, and can be formed using an etching, laminating or imprinting processes.
    Type: Application
    Filed: May 8, 2020
    Publication date: July 21, 2022
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Eric BROUZES, Jin Zhu YU, Anu Priya Bharathi RAJAN, Jingfang JU, Gabor BALAZSI
  • FABRICATING PHOTONICS STRUCTURE CONDUCTIVE PATHWAYS
    Publication number: 20220229228
    Abstract: There is set forth herein a method including fabricating a photonics structure having one or more photonics device. The method can include forming one or more conductive material formation for communicating electrical signals to and/or from the one or more photonics device.
    Type: Application
    Filed: April 16, 2020
    Publication date: July 21, 2022
    Applicant: The Research Foundation for the State University of New York
    Inventors: Douglas COOLBAUGH, Gerald LEAKE
  • Anti-fungals targeting the synthesis of fungal shingolipids
    Patent number: 11390580
    Abstract: The present invention provides a compound having the structure:
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: July 19, 2022
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Maurizio Del Poeta, Visesato Mor
  • Method and apparatus for high data rate long range acoustic and RF communication using chirp waveform modulation
    Patent number: 11394594
    Abstract: The present disclosure may be embodied as a transmitter for multiuser multicarrier-chirp-division-multiplexing (“MU-MCDM”) communications. The present disclosure may be embodied as a receive for MU-MCDM communications. The present disclosure may also be embodied as a method for transmitting an MU-MCDM communication signal. The present disclosure may also be embodied as a method for receiving an MU-MCDM communication signal.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: July 19, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: Dimitrios Pados, Stella Batalama, Georgios Skilvanitis, Song-Wen Huang
  • COMPOSITIONS AND METHODS FOR MODULAR CONTROL OF BIOORTHOGONAL LIGATION
    Publication number: 20220218661
    Abstract: The present invention provides a compound having the structure: wherein R1 is H or a protecting group; R2 and R3 are each independently H, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkyl-C(O)NHR6, C1-C6 alkyl-C(O)OR6, wherein R6 is H, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl, or R2 and R3 combine to form a 3-7 membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring; and R4 and R5 are each independently halo.
    Type: Application
    Filed: November 27, 2019
    Publication date: July 14, 2022
    Applicant: The Research Foundation for The State University of New York
    Inventors: Scott Laughlin, Pratik Kumar, Ting Jiang, Wei Huang
  • TERAHERTZ THREE-DIMENSIONAL SPECTRAL SCANNER APPARATUS AND METHOD OF USING SAME
    Publication number: 20220221335
    Abstract: Handheld, broadband terahertz (THz) scanners, housings therefor and imaging systems are provided. The scanner may comprise a 2-Dimensional (2D) gimbaled mirror for beam steering. The 2D gimbaled mirror may comprise a single minor mounted in a frame, a first motor and a second motor. The first motor and the second motor may be coupled to the frame. The minor may be rotatable in a first axis of rotation and a second axis of rotation to scan light on a target in two dimensions. The first motor corresponds to the first axis and the second motor corresponding to the second axis. The 2D gimbaled mirror may be positioned within the housing such that the single mirror is positioned at a focus of a focusing lens. The focusing lens may be fixed within a housing. The scanner may also comprise a terahertz emitter and detector.
    Type: Application
    Filed: March 11, 2020
    Publication date: July 14, 2022
    Applicant: The Research Foundation for The State University of New York
    Inventors: Mohammad Hassan ARBAB, Zachery HARRIS
  • High sensitivity photodetector with high-gain transimpedance amplifier
    Patent number: 11378447
    Abstract: One aspect of the present technology relates to a device. The device includes a sensor having an anode and a cathode. An operational amplifier (op-amp) having a single-ended output terminal, a non-inverting input, and an inverting input, is operatively coupled to one of the anode or the cathode of the sensor by the inverting input. A feedback resistor having a resistance of at least approximately one giga-ohm (1 G?) is operatively coupled between the single-ended output terminal and the inverting input of the op-amp. A grounded field shunt is positioned adjacent to the feedback resistor. The op-amp, grounded field shunt, and feedback resistor are disposed within an electrical shield enclosure. The single-ended output terminal of the op-amp terminates outside of the electrical shield enclosure.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: July 5, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: Anthony Costantino, Arkadii Perzov, Arvydas Matiukas
  • Fabricating photonics structure light signal transmission regions
    Patent number: 11378739
    Abstract: There is set forth herein a method including depositing a layer formed of barrier material over a conductive material formation of a photonics structure; and removing material of the layer in a light signal transmitting region of the photonics structure. In one embodiment the barrier material can include silicon carbon nitride. In one embodiment the barrier material can include silicon nitride.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: July 5, 2022
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Douglas Coolbaugh, Gerald L. Leake, Jr.
  • Telodendrimers with riboflavin moieties and nanocarriers and methods of making and using same
    Patent number: 11369614
    Abstract: Provided herein are compositions and nanocarriers comprising linear-dendritic telodendrimers (TD) containing riboflavin. The nanocarriers and compositions have desirable loading properties and stabilized structure and can be used for efficient in vivo delivery.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 28, 2022
    Assignee: The Research Foundation for the State University of New York
    Inventors: Juntao Luo, Dandan Guo, Changying Shi
  • Methods and compounds to inhibit enveloped virus release
    Patent number: 11369622
    Abstract: A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: June 28, 2022
    Assignees: Northwestern University, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Jonathan Leis, Carol Carter
  • Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization
    Patent number: 11371024
    Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: June 28, 2022
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Peter L. Collins, Cyril Le Nouën, Linda G. Brock, Ursula J. Buchholz, Joshua Marc DiNapoli, Steffen Mueller, Eckard Wimmer
  • SYSTEM AND METHOD FOR TRACKING HUMAN BEHAVIOR REAL-TIME WITH SINGLE MAGNETOMETER SENSOR AND MAGNETS
    Publication number: 20220185180
    Abstract: A system and method for monitoring and analyzing activities of a person operating a machine, particularly driving a vehicle, is provided. A first magnet is attached to a hand of the person and a second magnet is attached to the head of the person. A smart watch having a magnetometer is attached to the other hand of the person. The magnetometer is in magnetic communication with both the first magnet and the second magnet to generate a first magnetic signal and a second magnetic signal. Both signals can be received by a processor and applied to mathematical models by the processor to generate indicators representative of positions and motions of the hands and the head. An alarm can be generated based on the indicators.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 16, 2022
    Applicant: The Research Foundation for The State University of New York
    Inventor: Shan LIN
  • Keratin 17 as a biomarker for bladder cancer
    Patent number: 11360092
    Abstract: The current disclosure provides methods for detecting and analyzing K17 expression in a bladder sample obtained from a subject. The current disclosure also pertains to methods and kits for identifying a mammalian subject with bladder cancer by detecting the expression of K17 in a sample. The present methods include both cell-based and cell-free methods for determining the level of keratin 17 in a sample obtained from the bladder of a subject.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: June 14, 2022
    Assignees: The Research Foundation for The State University of New York, KDx Diagnostics, Inc.
    Inventors: Kenneth R. Shroyer, Luisa F. Escobar-Hoyos, Nam Kim
  • Synthetic disugar hydrocarbons as natural analogs to control microbial behaviors
    Patent number: 11357786
    Abstract: Synthetic disaccharide hydrocarbons (DSHs) that reactive bacterials swarming motility and inhibit bacterial adhesion and biofilm formation. A library of DSHs were tested in several experiment for the impact on various Pseudomonas aeruginosa populations and compared against existing compounds to determine efficacy and utility. Certain DSHs were also to determine the ability to clear bacteria in a mouse pneumonia model.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: June 14, 2022
    Assignees: Syracuse University, The Research Foundation for the State University of New York
    Inventors: Yan-Yeung Luk, Guirong Wang
  • Pressure-regulating implant and methods of use thereof
    Patent number: 11350921
    Abstract: Provided is an implant, including a chamber having an interior radius wherein the interior radius has a flange, a cover slip, a cup, a setting member, a securing member, a resistance member, and an opposing member, wherein the cover slip, cup, resisting member, and setting member are attached to one another, the setting member sets on a flange and the securing member secures the setting member to the flange, the resistance member includes a flexibility and a longitudinal axis with a length wherein the flexibility permits modification of the length, and the opposing member sets a minimum length of the longitudinal axis. Also provided is a method of using said implant including affixing the chamber to a skull of a mammal.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: June 7, 2022
    Assignee: The Research Foundation for the State University of New York
    Inventors: Stephen Macknik, Olivya Caballero, Manuel Ledo, Susana Martinez-Conde
  • Use of amine carboxyboranes as therapeutic delivery of carbon monoxide and as general drug delivery system in the presence of reactive oxygen species
    Patent number: 11352374
    Abstract: Disclosed is a method of delivering therapeutic carbon monoxide to the cells and tissues of a patient which comprises administering thereto a compound of the formula XBY1Y2C(O)V (I) or pharmaceutically acceptable salts thereof. In addition, disclosed is a method of delivering a drug to a diseased cell or tissue by administering a compound of formula I either wherein at least one of X is a drug containing an amino group or V is a drug containing an amino group or hydroxyl group less a hydrogen on the amino or hydroxyl group. Further disclosed are novel compounds of Formula I.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: June 7, 2022
    Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, FLORIDA SHOUTHWESTERN STATE COLLEGE, UNIVERSITY OF ALASKA ANCHORAGE
    Inventors: Nin N. Dingra, Theppawut Israsena Na Ayudhya
  • Magnetite (FeO)—multiwalled carbon nanotube composite structures with performance as high rate electrode materials for Li-ion batteries
    Patent number: 11349117
    Abstract: A method of synthesizing an electrode material for lithium ion batteries from Fe3O4 nanoparticles and multiwalled carbon nanotubes (MWNTs) to yield (Fe3O4-NWNTs) composite heterostructures. The method includes linking the Fe3O4 nanoparticles and multiwalled carbon nanotubes using a ?-? interaction synthesis process to yield the composite heterostructure electrode material. Since Fe3O4 has an intermediate voltage, it can be considered an anode (when paired with a higher voltage material) or a cathode (when paired with a lower voltage material).
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: May 31, 2022
    Assignee: The Research Foundation for the State University of New York
    Inventors: Stanislaus Wong, Lei Wang, Coray McBean, Amy C. Marschilok, Kenneth Takeuchi, Esther S. Takeuchi