Abstract: A method and apparatus for enhancing an auditory signal to make sounds, particularly speech sounds, more distinguishable. An input auditory signal is divided into a plurality of spectral channels. An output gain for each channel is derived based on the time varying history of the energy in the channel and, preferably, the time varying history of energy in neighboring channels. The magnitude of the output gain for each channel thus derived is preferably inversely related to the history of energy in the channel. The output gain derived for each channel is applied to the channel to form a plurality of modified spectral channel signals. The plurality of modified spectral channel signals are combined to form an enhanced output auditory signal. The present invention is particularly applicable to electronic hearing aid devices, speech recognition systems, and the like.

Abstract: An ultrasound machine measures coronary intima-medial thickness and relates it to a statistically derived vascular age. Quantitative risk of coronary heart disease may be calculated using vascular age to substitute for chronological age in publicly available risk assessment data.

Abstract: Gene delivery vectors, for example, recombinant FIV vectors, and methods of using such vectors are provided for use in treating or preventing retinal diseases of the eye and diseases of the brain associated with lysosomal storage disorders.

Abstract: A method and apparatus for surface measurement using the shadow moire effect with the Talbot effect. The apparatus includes a specimen mount to receive a specimen having a surface to be measured, and a reference grating mounted adjacent to the specimen mount so as to be substantially parallel to a mean surface plane of the specimen. The reference grating is mounted in such a manner that the distance between the reference grating and the mean surface plane of the specimen can be adjusted to a Talbot distance &dgr;T. The apparatus also includes a light source to illuminate the specimen through the grating and a detector positioned to detect the moire fringes produced by the grating due to variation of the surface of the specimen.

Abstract: This invention provides a novel class of vitamin D related compounds, namely, the 2-alkyl-19-nor-vitamin D derivatives, as well as a general method for their chemical synthesis.

Abstract: A brain implant system consistent with embodiments of the present invention includes an electrode array having a plurality of electrodes for sensing neuron signals. A method for manufacturing the electrode array includes machining a piece of an electrically conductive substance to create a plurality of electrodes extending from a base member. Each electrode also has a corresponding base section. A nonconductive layer is provided around at least a portion of the base section of each electrode to support the plurality of electrodes. The base section of the electrodes are then cut to separate the base member from the plurality of electrodes supported by the nonconductive support layer. The present invention also includes a complete brain implant system using the above electrode array.

Abstract: The present invention is to &mgr;-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the &mgr;-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The &mgr;-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the &mgr;-conopeptides and encoding propeptides, as well as the propeptides.

Abstract: The subject invention concerns a method for therapeutically treating a patient afflicted with autoimmune disorders or disease. The subject method comprises administering to a patient an antibody composition that is capable of binding to and inhibiting self-reactive pathogenic antibodies present within the patient. Specifically exemplified is a method for treating systemic lupus erythematosis wherein the antibody composition administered to the patient comprises purified anti-DNA anti-idiotypic antibodies. The subject invention further concerns a method for purifying from pooled human gamma globulin preparations anti-idiotype antibodies useful in the present therapeutic method. The present invention further concerns a purified antibody composition useful in the present therapeutic method.

Abstract: A thermocoustic device includes a housing with a thermal core supported in the housing and having a first and a second surface. The thermal core includes a first heat exchanger defining the first surface of the thermal core and a second heat exchanger defining the second surface of the thermal core. A main chamber is in fluid communication with the first surface of the thermal core and a secondary multiplier chamber is in fluid communication with the second surface of the thermal core. A working volume of a gaseous working fluid fills the main chamber, the multiplier chamber, and the thermal core at a pressure. An equilibrium pressure is defined as the pressure of the working volume of gaseous working fluids with the thermoacoustic device is in a non-operating mode.

Abstract: Suspended single crystal silicon (SCS) beams coated with metal form transmission lines that are used in MEMs type microactuated phase shifters and switches. The characteristic impedance of any section of the transmission lines is a function of the beam spacing in that section. Microactuators, such as comb-drive actuators, are connected to the beams to vary this spacing in a controllable manner. A continuos phase shifter is formed that consists of two tunable capacitance sections connected by a matching section that reduces reflections and improves compliance of the beams to reduce the energy required to move the beams.

Abstract: The invention provides compounds of formula I: wherein X, R1, R2, and n have any of the values defined in the specification, and their pharmaceutically acceptable salts. The compounds are useful, for example, for blocking prenylation transferase enzymes, for probing or diagnosing protein prenylation processes, and for treating cancer in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and intermediates useful for the synthesis of compounds of formula I.

Abstract: Chiral phosphine ligands derived from chiral natural products including D-mannitol and tartaric acid. The ligands contain one or more 5-membered phospholane rings with multiple chiral centers, and provide high stereoselectivity in asymmetric reactions.

Abstract: A three dimensional mask of the lungs can be automatically created by thresholding, labeling connected components, selecting the dominant object, and alternately employing dilation and erosion operations. With this mask the lungs can be separated from the other anatomic structures on volumetric CT images. Local density maxima in the lungs are then determined by sequentially decreasing thresholds. As the threshold declines, more and more objects (a 3D object is a group of connected voxels with density values larger than the threshold) become apparent. Geometrically overlapped objects at the subsequent threshold levels are either merged into one object or identified as local density maximum (maxima) and plateau. This process terminates if the threshold reaches a predefined density value. Other information about small lung nodules such as compact shape and size are combined into the algorithm to further remove those detected local density maxima that are not likely to be nodules.

Abstract: The charge state of ions produced by electrospray ionization is reduced in a controlled manner to yield predominantly singly charged ions through reactions with bipolar ions generated using a 210Po alpha particle source or equivalent. The multiply charged ions generated by the electrospray undergo charge reduction in a charge reduction chamber. The charge-reduced ions are then detected using a commercial orthogonal electrospray TOF mass spectrometer, although the charge reduction chamber can be adapted to virtually any mass analyzer. The results obtained exhibit a signal intensity drop-off with increased oligonucleotide size similar to that observed with MALDI mass spectrometry, yet with the softness of ESI and without the off-line sample purification and pre-separation required by MALDI.

Abstract: A class of novel compounds is described for use in affecting lymphatic absorption of cholesterol. Compounds of particular interest are defined by Formula I: or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are cyclic imino oligomers and polymers comprised of subunits of the formula: Also disclosed are combinatorial libraries and arrays of the cyclic imino compounds.

Abstract: The Heartbeat Failure Detector of the present invention, is a new, simple method and device that has several identical modules, and each module is attached to a processor in the system. Roughly speaking, the module of a processor x maintains a heartbeat counter for every other process. For each process y, the counter of y at x (called the heartbeat of y at x) periodically increases while y is alive and in the same network partition, and the counter stops increasing after y crashes or becomes partitioned away. Using such a device, x can solve the communication problem above by resending m only if the heartbeat of y at x increases. Note that if y is crashed (or partitioned away from x), its heartbeat at x stops almost immediately, and so x will also immediately stop sending copies of m to y.

Abstract: The combination of HIV proteins Tat and Nef is chemotactic for CD4+ cells. Utilizing the capacity of Tat and Nef to modulate CD4+ cell trafficking and infiltration, the invention provides various treatment modes for individuals infected with HIV. The invention further provides treatment modes for other localized diseases by controlling CD4+ cell trafficking and infiltration. In particular, the invention provides methodology for promoting CD4+ cell chemotaxis to a localized site of infection as a means of augmenting the efficacy of extant chemotherapeutic methods. The invention further provides methodology for diverting CD4+ cell infiltration from a localized site where the presence of CD4+ cells is detrimental to the clinical outcome, by providing a composition comprising Tat and Nef at a distinct site, such as blood, within the individual where the accumulation of CD4+ cells is less detrimental.

Abstract: A process for fabricating a ceramic electroactive transducer of a predetermined shape is disclosed. The process comprises the steps of providing a suitably shaped core having an outer surface, attaching a first conductor to the outer surface of the core, coating an inner conductive electrode on the the outer surface of the core such that the inner conductive electrode is in electrical communication with the first conductor, coating a ceramic layer onto the inner electrode, thereafter sintering the ceramic layer, coating an outer electrode onto the sintered ceramic layer to produce an outer electrode that is not in electrical communication with the first conductor, and then poling the sintered ceramic layer across the inner electrode and the outer electrode to produce the ceramic electrode.

Abstract: Biodegradable and/or bioabsorable fibrous articles and methods for using the articles in medical applications are disclosed. The biodegradable and/or bioabsorable fibrous articles, which are formed by elctrospinning fibers of biodegradable and/or bioabsorbable fiberizable material, comprise a composite (or asymmetric composite) of different biodegradable and/or bioabsorbable fibers. Articles having specific medical uses include an adhesion-reducing barrier and a controlled delivery system. The methods include methods for reducing surgical adhesions, controlled delivery of a medicinal agent and providing controlled tissue healing.