Abstract: An apparatus for spectral narrowing of high power diode laser arrays includes a high power diode laser array configured for production of an output light beam, a collimator configured for collimation of the output light beam, and a half-wave plate and polarizing beamsplitter positioned to receive the output light beam and to separate it into a feedback beam and a usable beam. The apparatus further includes an interference filter positioned to receive the feedback beam and form it into a filtered feedback beam. The filter has a narrow passband about a desired wavelength. The apparatus still further includes a cat's eye reflector to receive the feedback beam, direct it through the interference filter, and couple the filtered feedback beam into the diode laser array.

Abstract: A fluorescent polymer having the moiety ##STR1## is disclosed. R.sub.1 and R.sub.2 are H.sub.1 alkyl, or aromatic. R.sub.3, R.sub.4, and R.sub.5 are aromatic. A preferred fluorescent composition may be formed by combining the fluorescent polymer with a second polymer, such as polystyrene or polysilystyrene.

Abstract: The subject invention concerns novel peptides which have the property of interfering with the biosynthesis of the enzyme trypsin. This property enables the use of these peptides to, for example, inhibit the formation of progeny in blood-ingesting insects, since trypsin is an essential enzyme for food digestion which provides the essential building blocks for egg development in such insects.

Abstract: A method of extracting metal and metalloid species from a solid or liquid substrate using a supercritical fluid solvent containing one or more chelating agents followed by back-extracting the metal and metalloid species from the metal and metalloid chelates formed thereby. The back-extraction acidic solution is performed utilizing an acidic solution. Upon sufficient exposure of the metal and metalloid chelates to the acidic solution, the metal and metalloid species are released from the chelates into the acid solution, while the chelating agent remains in the supercritical fluid solvent. The chelating agent is thereby regenerated and the metal and metalloid species recovered.

Abstract: The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.

Abstract: The present invention relates to the discovery that certain .beta.-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high activity against Epstein-Barr virus (EBV). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus (viral growth) in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds are useful for treating EBV infections in humans.

Abstract: A new RNA polymerase transcription factor has been discovered. The enzyme significantly increases the rate of transcription elongation by RNA polymerase II.

Abstract: Method and apparatus are provided for cardiac defibrillation using a waveform with a dominant frequency near that of a fibrillating heart. The defibrillator includes electrical generating means for producing a waveform having a dominant frequency within a range of 2 Hz-20 Hz. The waveform provides low level electrical shock to a fibrillating heart, thereby causing defibrillation. The waveform, which can comprise a Rossler-type chaotic waveform or a sinusoidal waveform, preferably has a dominant frequency near the frequency of fibrillation of the fibrillating heart.

Abstract: The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.

Abstract: A device capable of providing non-invasive, accurate estimates of central venous pressure. This diagnostic device is particularly useful with patients suffering from cardiac disease.

Abstract: Use of D2-sevoflurane is disclosed as an inhalational anesthetic. Deuterated sevoflurane possess all of the desirable qualities of sevoflurane as an anesthetic and is metabolized more slowly thereby reducing potentially toxic inorganic fluoride release. More particularly, the compound fluorodideutero methyl 1,1,1,3,3,3-hexafluoropropyl ether is disclosed as well as a method for synthesis.

Abstract: Disclosed are synthetic oligonucleotides having a nucleotide sequence complementary to CAPL nucleic acid. Also disclosed are methods of inhibiting the expression of CAPL gene and methods of inhibiting metastatic cancer using CAPL-specific oligonucleotides.

Abstract: A test device for detecting or determining an analyte in a test solution includes an absorbent material having separate contact, competitive binding, and measurement portions. The contact portion is positioned for contact with and uptake of the test solution. The competitive binding portion has a binding material for the analyte non-diffusively bound thereto. The measurement portion has a receptor for the analyte and marker-encapsulating liposomes non-diffusively bound thereto. In a method for using the test device, a solution containing the analyte and the analyte-liposome conjugate is allowed to traverse the absorbent material from the contact portion through the competitive binding portion and on through the measurement portion of the absorbent material. The amount of marker in the measurement portion of the absorbent material, following traversal by the test solution, is then determined as a measure of the analyte in the sample.

Abstract: A concatenated trellis coded modulation and linear block (e.g., Reed-Solomon) encoding scheme splits data to be encoded into two data streams, one of which is both linear block encoded and trellis encoded, and the other of which either remains uncoded or is encoded with a weaker strength linear block code. The coding scheme requires the use of a special decoder which decodes the trellis encoded data first, and then uses the resulting information to decode the non-trellis encoded information. In embodiments using linear block coding for the non-trellis encoded data stream, the relative strengths of the two linear block encoders are selected to balance the resulting code, thereby maximizing coding gain and efficiency.

Abstract: The synthesis of an aramid by the catalyzed reaction of carbon monoxide, an aromatic dichloride, such as 1,4-dichlorobenzene, and a diamine, such as 1,4-diaminobenzene, is disclosed. The reaction may be catalyzed by palladium (II) and palladium (0)-containing catalysts with chelating trialkyl phosphines, such as bis(diisopropylphosphino)-propane.

Abstract: The present invention relates to a method of treating a patient with a fibrotic or fibroproliferative disorder and a method of suppressing formation of collagen and collagen-like substances or biosynthesis of procollagen in living systems by administering to a patient or living system, respectively, an effective amount of a compound of Formulae (I) or (II) and derivatives thereof: ##STR1## R.sub.1, R.sub.2, R.sub.3, and R.sub.4 each individually represent a hydrogen, an alkyl, alkenyl, or alkoxy group containing 1 to about 8 carbon atoms, an aryl, aralkyl, or cycloalkyl group containing about 5 to 12 carbon atoms, or a carboalkoxy or carbamyl group containing up to 8 carbon atoms, or a peptide or peptidomimetic moiety containing 10 to about 30 carbon atoms.

Abstract: Novel sequences in the genome of a wild type isolate of chicken infectious anemia virus are described. The amino acid sequence of a polypeptide, VP1, encoded by a novel sequence is also disclosed. Additionally, disclosed are the unexpected properties of the isolate which are related to novel amino acids positioned in the amino acid sequence of this isolate's VP1, as compared to the sequence of VP1 found in cell culture-adapted strains; and use of the novel sequences and their respective polypeptides in strategies to control chicken infectious anemia such as by vaccination.

Abstract: The invention relates to a method of synthesizing 1,1,1,3,3,3-hexafluoropropanes comprsing the additon of BrF.sub.3 to malononitrile.

Abstract: A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the mammalian system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.

Abstract: A ligand dependent co-activator for the human androgen receptor has been identified. The co-activator, named here ARA.sub.70, potentiates interaction between androgens and the receptor. The co-activator is useful as a tool in monitoring the androgenic/antiandrogenic effects of possible pharmaceuticals as well as environmental samples. The cDNA for co-activator has been cloned and sequenced.