Patents Assigned to The Research Foundation
  • BIOMARKER DETECTION DEVICE
    Publication number: 20190329242
    Abstract: The disclosure is directed to a device that includes an upper container configured to receive a fluid sample collected from a mammal into a first opening, the first opening opposite a second opening and a membrane covering at least a portion of the second opening, the membrane configured to allow transmission of a portion of the fluid sample through the membrane.
    Type: Application
    Filed: January 3, 2018
    Publication date: October 31, 2019
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Srinivas PENTYALA, Sahana PENTYALA
  • CO-SPRAY DRYING OF MEROPENEM AND COLISTIN AND THE USES THEREOF
    Publication number: 20190328669
    Abstract: The present disclosure generally relates to a process for manufacturing a dry powder composition, particularly to a co-sprayed colistin and meropenem dry powder inhaler for the treatment of various bacterial infections. Methods of use and composition matters are within the scope of this disclosure.
    Type: Application
    Filed: April 26, 2019
    Publication date: October 31, 2019
    Applicant: Purdue Research Foundation
    Inventors: Qi Zhou, Sharad Mangal
  • CO-SPRAY DRYING OF CIPROFLOXACIN AND COLISTIN AND THE USES THEREOF
    Publication number: 20190328728
    Abstract: The present disclosure generally relates to a combination dry powder inhaler (DPI) formulation of Ciprofloxacin and Colistin through co-spray drying, particularly to a co-sprayed colistin and Ciprofloxacin dry powder inhaler for the treatment of various bacterial infections. Methods of use and composition matters are within the scope of this disclosure.
    Type: Application
    Filed: April 26, 2019
    Publication date: October 31, 2019
    Applicant: Purdue Research Foundation
    Inventors: Qi Zhou, Nivedita Shetty
  • METHODS FOR REDUCING OXIDATIVE DAMAGE
    Publication number: 20190328821
    Abstract: The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic peptide. The aromatic cationic peptide has (a) at least one net positive charge; (b) a minimum of three amino acids; (c) a maximum of about twenty amino acids, (d) a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3 pm is the largest number that is less than or equal to r+1; (e) a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 3a or 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1; and (f) at least one tyrosine or tryptophan amino acid.
    Type: Application
    Filed: April 19, 2018
    Publication date: October 31, 2019
    Applicant: Cornell Research Foundation, Inc.
    Inventor: Hazel H. Szeto
  • ARYL ISONITRILES AS A NEW CLASS OF ANTIMICROBIAL COMPOUNDS
    Publication number: 20190330154
    Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 31, 2019
    Applicant: Purdue Research Foundation
    Inventors: Mohamed Seleem, Mingji Dai, Dexter Cameron Davis, Haroon Taj Mohammad
  • BEAM DEFLECTOR, HOLOGRAPHIC DISPLAY DEVICE HAVING THE SAME, AND METHOD OF DRIVING THE BEAM DEFLECTOR
    Publication number: 20190331980
    Abstract: A beam deflector, a holographic display device including the beam deflector, and a method of driving the beam deflector are provided. The beam deflector includes first electrodes spaced apart from each other on a first substrate, second electrodes spaced apart from each other on a second substrate, a liquid crystal layer between the first substrate and the second substrate, and a controller configured to cause active prisms to be formed in the liquid crystal layer and to form a floating zone by turning off a voltage of at least one of the first electrode and the second electrode disposed between adjacent ones of the active prisms.
    Type: Application
    Filed: September 4, 2018
    Publication date: October 31, 2019
    Applicants: SAMSUNG ELECTRONICS CO., LTD., SOGANG UNIVERSITY RESEARCH FOUNDATION
    Inventors: Young KIM, Kanghee WON, Himchan PARK, Jinwook BURM, Hoon SONG, Hongseok LEE
  • Miniaturized continuous-flow fermenting apparatus
    Patent number: 10457904
    Abstract: A system, method, and apparatus for the fermentation of a beverage by use of continuous flow is provided. The fermented beverage can be any of a wine, beer, mead, ale, soda, cider, or other. The invention provides for small-scale fermentation that can be done in a much shorter time than previous batch fermentations. The small-scale and shortened time allows for variables to be introduced and tested to produce new varieties, flavors, qualities, and other combinations that are inputs of the fermented beverage.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: October 29, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Daniel Attinger, Liang Dong, Yuncong Chen
  • SCN plants and methods for making the same
    Patent number: 10457956
    Abstract: The invention relates to genes which may be utilized for resistance to soybean cyst nematode. More specifically the present disclosure relates to identification of gene(s) that can confer upon a soybean plant resistance to soybean cyst nematode (SCN) and methods to use these loci and genes to obtain soybean strains that are resistant to SCN.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Tarek Abdelfattah Hewezi, Aditi Rambani, C. Neal Stewart, Jr., Mitra Mazarei, Vincent Pantalone
  • Gait rehabilitation systems, methods, and apparatuses thereof
    Patent number: 10456318
    Abstract: Gait rehabilitation systems, methods, and apparatuses thereof are disclosed. In accordance with one aspect of the invention, a gait rehabilitation system may include a harness configured for attachment to an individual and at least one sensor configured to sense at least one parameter associated with gait of an individual, the individual having an affected leg and an unaffected leg. The system includes a braking system configured for attachment to the harness and in communication with the at least one sensor. The braking system is further configured for monitoring the at least one sensor to sense the at least one parameter associated with an individual's gait, determining when the affected leg is in a modification portion of the individual's gait from the sensed at least one parameter, and applying a braking force resisting movement of the harness during the determined modification portion.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: October 29, 2019
    Assignees: The Trustees of the University of Pennsylvania, The Research Foundation for the State University of New York
    Inventors: Katherine J. Kuchenbecker, Vivienne Clayton, Ilana Teicher, Siyao Hu, Erin Vasudevan
  • Generating an object map from a plurality of binary images
    Patent number: 10460219
    Abstract: In an example, a method is described that includes dividing an input image into a plurality of strips, where each strip is smaller than a whole of the input image. A plurality of binary images is then generated, where each of the binary images corresponds to one of the strips. Connected component labeling is performed on the binary images, one binary image at a time. An object map for the input image is then generated based on the results of the connected component labeling.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: October 29, 2019
    Assignees: Hewlett-Packard Development Company, L.P., Purdue Research Foundation
    Inventors: Brent Michael Bradburn, Zuguang Xiao, Mengqi Gao, Lu Wang, Jan P. Allebach
  • Proppant for use in hydraulic fracturing to stimulate a well
    Patent number: 10457859
    Abstract: A proppant for use in hydraulic fracturing to stimulate a well is provided. The proppant is fly ash particles having a mean particle size (d50) of between 45 ?m and 150 ?m and a size distribution defined by (d10)?5 ?m and (d98)?250 ?m.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Thomas Lee Robl, Anne Elizabeth Oberlink
  • Fatty acid ester-based wax compositions and methods of making thereof
    Patent number: 10457892
    Abstract: This invention relates to a wax composition comprising one or more fatty acid diester compounds having the formula of R1 and R2 are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; and n1 is an integer from 2 to 10. This invention also relates to a wax composition comprising: a) one or more fatty acid monoester or diester compounds having the formula of: and b) one or more hydroxylated fatty acid diester compounds having the formula of In these formulae, R is H or COR1?; R1? and R2? are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; n2 is an integer from 2 to 24; m is an integer from 2 to 12; and .(OH)m represents 2 to 12 hydroxyl groups substituting for 2 to 12 hydrogen atoms in the alkyl groups R1? and/or R2?. Uses of the compositions are also disclosed.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: October 29, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Tong Wang, Tao Fei
  • Oligolactic acid conjugates and micelles with enhanced anticancer efficacy
    Patent number: 10456477
    Abstract: The present technology relates generally to oligolactic acid conjugates of paclitaxel, rapamycin, selumetinib, and other anticancer agents, micelle compositions containing such conjugates and methods of preparing and using such compositions to treat various cancers. Specifically, there are provided oligolactic acid conjugates wherein the oligolactic acid comprises 2 to 24 lactic acid subunits and is attached through an ester linkage to the oxygen of the 7-hydroxyl of the paclitaxel or paclitaxel derivative, the 40-hydroxyl of the rapamycin or rapamycin derivative, and the 2?-hydroxyl of the selumetinib or selumetinib derivative. Compositions comprising water and a micelle comprising a polylactic acid-containing polymer and the oligolactic acid conjugate may be readily prepared. Methods of inhibiting or killing cancer cells and treating paclitaxel, rapamycin, and/or selumetinib cancers are also provided.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: October 29, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Glen S. Kwon, Yu Tong Tam
  • Increased thermal stabilization of optical absorbers
    Patent number: 10459121
    Abstract: Compositions for increasing the thermal stability of optical absorbers are provided as well as methods of making and using the resulting compositions. The compositions or complexes of the present teachings generally include an optical absorber bound to a metal or a metal oxide through one or more linkers, which contain a metal binding moiety.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 29, 2019
    Assignees: The Research Foundation for the State University of New York, Crysta-Lyn Chemical Company, Inc.
    Inventors: William E. Bernier, Megan Fegley, Bradley Galusha, Francis D. Goroleski, Wayne E. Jones, Kenneth H. Skorenko
  • Platinum prodrugs and methods of making and using thereof
    Patent number: 10457700
    Abstract: Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs release the platinum containing anticancer agent and the alkylating agent, which can form an adduct with DNA or can protect the platinum containing agent from removal. The disclosed prodrugs can be used to treat various cancers, including cisplatin resistant cancers.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Shanta Dhar, Rakesh Pathak
  • Methods of producing solid fuel using low ash, low sulfur coal replacement from fast pyrolysis of biomass
    Patent number: 10457882
    Abstract: The present invention is directed to a method of producing a solid fuel which includes providing a bio-oil and thermally curing the bio-oil to form a carbonaceous solid. The present invention is also directed to a method of producing a solid fuel which includes providing a bio-oil; subjecting the bio-oil to an extraction procedure with an aqueous liquid to produce a concentrated pyrolytic sugar-containing extract and a water insoluble raffinate comprising a lignin-derived phenolic oil; and thermally curing the phenolic oil to form a carbonaceous solid.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: October 29, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Robert C. Brown, Marjorie Rover, Andrew J. Friend, Ryan G. Smith
  • Educational systems comprising programmable controllers and methods of teaching therewith
    Patent number: 10456910
    Abstract: Systems and methods for hands-on training of students. Such a system includes one or more programmable controllers configured to interact with one or more external devices. Each programmable controller includes a microcontroller, a memory device, an interface for remotely accessing the programmable controller, and at least one bus interface for interfacing with an external microcontroller of another programmable controllers. The method includes functionally coupling a first of the programmable controllers to an external device, programming the first programmable controller to operate the external device, and providing instructions to the external device through the programmable controller from a remote location relative to the first programmable controller.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: October 29, 2019
    Assignee: Purdue Research Foundation
    Inventor: Larry Eugene Himes, Jr.
  • Adenylyl cyclase inhibitors for chronic pain and opioid dependence
    Patent number: 10457653
    Abstract: This present application disclosed a series of selective adenylyl cyclase 1 (AC1) inhibitors, compounds having a formula or a pharmaceutically acceptable salt thereof, as a pain therapeutic. Those compounds may provide an effective method of treatment for chronic/inflammatory pain. Those compounds may also prevent opioid dependence and/or reduce opioid dependence. Both method and composition matters are within the scope of this invention.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 29, 2019
    Assignee: Purdue Research Foundation
    Inventors: Val J. Watts, Richard M. van Rijn, Daniel Patrick Flaherty, Jatinder Kaur
  • Device for obtaining small, precise volumes of fluid from animals
    Patent number: 10456068
    Abstract: A “one-step”, single-handed device for obtaining small, precise volumes of fluid from animals is able to quickly and easily draw a fluid sample. The device comprises an extraction component and a collection component that are coupled together and disposed along a grip handle. The user manipulates the device so as to initiate the extraction of the fluid, and then collect the fluid in a component that can quickly and easily be removed from the grip handle—allowing the handle to be re-loaded and used again and again. The extraction component may comprise a hypodermic needle and the collection component may comprise a pre-calibrated pipette, where the pipette is positioned directly behind the needle and will thus draw the extracted fluid into a pre-sized chamber within the pipette.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: October 29, 2019
    Assignees: Med-Ag Industries, Inc., The Penn State Research Foundation
    Inventors: John V. Vargo, Louis M. Bassler, Troy L. Ott, Robert W. VanDine
  • System and method for performing exercise testing and training
    Patent number: 10456624
    Abstract: Disclosed are various approaches for determining the maximum oxygen consumption of a person, also known as maximum aerobic capacity or VO2 Max. A person is positioned on a treadmill. Attached to the person is a harness configured to apply a horizontal force to the person. A work rate for the person can be calculated based at least in part on the magnitude of the horizontal force applied by the harness and the velocity of the belt. The maximum oxygen consumption for the person can then be calculated based at least in part on the previously calculated work rate.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: October 29, 2019
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: David A. Brown, Christopher Hurt, Marcas Bamman