Abstract: A method for generating a electro spun fiber medical implant including determining dimensions of a portion of anatomy of a patient corresponding to the electro spun fiber medical implant via medical imaging, generating a model of the portion of the anatomy based on the dimensions, the model including one or more solid areas and one or more void areas encompassed within the one or more solid areas, inverting the model to generate a mandrel model, the mandrel model generated based on the one or more void areas, generating the mandrel based on the mandrel model, the mandrel including at least one electrically conductive material therein, and applying an electro-spinning process to the mandrel to generate the electro spun fiber medical implant which circumscribes the mandrel, wherein the mandrel is removable from within the electro spun fiber medical implant after a disassembly process.
Type:
Grant
Filed:
August 26, 2016
Date of Patent:
January 19, 2021
Assignees:
CHILDREN'S NATIONAL MEDICAL CENTER, RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, NANOFIBER SOLUTIONS LLC
Inventors:
Axel Krieger, Narutoshi Hibino, Jed Johnson, Justin Opfermann, Carolyn Cochenour Dorgan, Christopher K. Breuer
Abstract: The disclosure relates to methods for treating subjects with musculoskeletal diseases or with muscle wasting not associated with a musculoskeletal disease by gene transfer with recombinant adeno-associated viruses (rAAV) encoding myostatin inhibitors such as follistatin-344. The rAAV are administered prior to development of diffuse muscle fibrosis in a subject, or the rAAV administration avoids regions of muscle fibrosis in a subject.
Type:
Grant
Filed:
October 9, 2015
Date of Patent:
November 24, 2020
Assignee:
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
Inventors:
Jerry R. Mendell, Brian K. Kaspar, Samiah Al-Zaidy
Abstract: The disclosure relates to gene therapy vectors, such as AAV vectors, comprising a polynucleotide encoding ?-sarcoglycan (SGCG) and methods of using such gene therapy vectors to treat subjects suffering from a muscular dystrophy, e.g. limb girdle dystrophy type 2C (LGMD2C).
Type:
Application
Filed:
January 30, 2019
Publication date:
November 19, 2020
Applicant:
Research Institute at Nationwide Children's Hospital
Abstract: A cryopreservation instrument and method of using is provided. The instrument includes a substantially planar elongated member comprising a cryosafe material. The elongated member has a first end and a second end. The first end comprises a cap insert dimensioned and configured to be fit in the interior recess of a vial cap, the second end comprises a biological contact portion configured to accommodate biological material.
Type:
Grant
Filed:
September 2, 2015
Date of Patent:
November 17, 2020
Assignee:
Research Institute at Nationwide Children's Hospital
Abstract: The present invention relates to RNA-based methods for inhibiting the expression of the superoxide dismutase 1 (SOD-1) gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding RNAs that knock down the expression of SOD-1. The methods have application in the treatment of amyotrophic lateral sclerosis.
Type:
Grant
Filed:
July 20, 2018
Date of Patent:
October 6, 2020
Assignees:
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, LUDWIG INSTITUTE FOR CANCER RESEARCH
Inventors:
Brian K. Kaspar, Kevin Foust, Don W. Cleveland
Abstract: Embodiments disclosed herein provide compositions, methods, and uses for respiratory syncytial viruses (RSV) and immunogenic compositions thereof. Certain embodiments provide RSV having cleavage-resistant mutated attachment (G) glycoproteins. In some embodiments, the cleavage-resistant G protein mutants increase production of live attenuated RSV in host cells. Also provided are methods for amplifying RSV in host cells, wherein the amplified RSV has full length G protein. In certain embodiments, the amplified RSV having full length G protein is formulated into immunogenic compositions, including vaccines. Other embodiments provide methods for inducing an effective immune response against RSV infection in a subject.
Type:
Grant
Filed:
June 17, 2016
Date of Patent:
September 1, 2020
Assignee:
The Research Institute at Nationwide Children's Hospital
Inventors:
Mark Edward Peeples, Steven A. Kwilas, Jacqueline Dianne Corry
Abstract: This disclosure provides pharmaceutical compositions and purified or isolated naturally occurring exosome products that have therapeutic use for treating an unmet medical need. The exosome compositions contain an effective amount of exosomes isolated from a body fluid of a non-diseased subject. The compositions are useful in the treatment of a variety of fibrotic diseases.
Type:
Application
Filed:
February 18, 2020
Publication date:
August 20, 2020
Applicant:
Research Institute at Nationwide Children's Hospital
Abstract: Provided are topical delivery systems and methods for treating and/or preventing a disease or disorder in a subject, or for eliciting an immune response in a subject including applying, to at least a portion of the subject's post-auricular region, a topical delivery system including a therapeutically effective amount of a topical pharmaceutical composition comprising at least one active agent and a pharmaceutically acceptable carrier and/or adjuvant. The topical pharmaceutical composition can include a topical immunogenic composition. The topical delivery system can further include a flexible substrate in communication with the topical immunogenic composition. The subject can be a pediatric subject.
Type:
Grant
Filed:
November 28, 2017
Date of Patent:
July 28, 2020
Assignee:
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
Abstract: Modified capsid proteins, isolated polynucleotides, methods for the preparation of modified capsid proteins, recombinant viral particles, recombinant expression systems for the generation of modified viral particles, and methods of gene editing and regulation are provided herein.
Type:
Application
Filed:
June 4, 2018
Publication date:
May 21, 2020
Applicant:
Research Institute at Nationwide Children's Hospital
Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
Type:
Application
Filed:
June 21, 2019
Publication date:
May 21, 2020
Applicants:
Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
Inventors:
Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
Abstract: A medical testing apparatus and method of use for for penetrating a patient's tissue with an agent, the apparatus comprises an arcuate rail having spaced first and second sides supported by upper and lower arcuate surfaces and an arcuate handle having first and second ends extending from the upper surface of the arcuate rail. A plurality of tips extend substantially from and normally outward as the lower arcuate surface. The plurality of tips comprises alternating blunt tips and reed tips.
Type:
Grant
Filed:
March 12, 2014
Date of Patent:
May 19, 2020
Assignees:
Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
Inventors:
Amber M. Patterson, Benjamin A. Patterson, Jay A. Shepherd, Meagan W. Shepherd
Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
Type:
Grant
Filed:
July 13, 2017
Date of Patent:
April 21, 2020
Assignees:
Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
Inventors:
Steven D. Goodman, Lauren O. Bakaletz, Michael Bailey, Gail Besner
Abstract: An apparatus and system for analyzing one or more points of interest. The apparatus includes a main support having first and second legs. The first and second legs extending transversely from the main support. The main support nests an imaging device capable of capturing an image of a point of interest during use. An imaging shroud is coupled to and extending from the first leg, the shroud having a first opening for surrounding the point of interest. A second opening in the shroud is positioned such that it extends to be within the main support for the passage of a captured image of the point of interest during use.
Type:
Grant
Filed:
November 15, 2016
Date of Patent:
February 25, 2020
Assignee:
Research Institute at Nationwide Children's Hospital
Inventors:
Robert V. Strouse, Jeremy Patterson, Kara Rood, Irina Buhimschi
Abstract: The present disclosure relates to a novel CRISPR-Cas9 based system for editing mitochondrial DNA. Aspects of the disclosure provide for mitochondrial translocation of both the guide RNA and the recombinant Cas9 nuclease.
Type:
Application
Filed:
November 15, 2017
Publication date:
January 30, 2020
Applicant:
Research Institute at Nationwide Children's Hospital
Inventors:
Kenneth John McLaughlin, Syed-Rehan Ashfaq Hussain
Abstract: This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
Type:
Application
Filed:
August 16, 2018
Publication date:
January 2, 2020
Applicant:
Research Institute at Nationwide Children's Hospital
Abstract: Provided herein are microspheres containing an antimicrobial agent encapsulated within a glycosidic polymer and use thereof, especially to inhibit the growth of carie-causing organism.
Type:
Application
Filed:
June 11, 2019
Publication date:
December 26, 2019
Applicant:
Research Institute at Nationwide Children's Hospital
Inventors:
Steven David Goodman, Lauren Mashburn Warren
Abstract: This disclosure provides antibody fragments and isolated polypeptides comprising the antibody fragments that are useful as a therapeutic for those with an existing infection characterized by the formation of biofilms. Antibody fragments and isolated polypeptides comprising the antibody fragments can be administered to detect, treat, or prevent infection and/or remediate biofilms. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
Type:
Application
Filed:
January 3, 2018
Publication date:
November 7, 2019
Applicant:
Research Institute at Nationwide Children's Hospital
Abstract: The disclosure provides methods and compositions that are useful to lessen and/or cure bacterial biofilms and treat diseases or disorders associated with biofilms using one or more novel polypeptide vaccines, antibodies, antibody fragments and compositions. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
Type:
Application
Filed:
January 3, 2018
Publication date:
November 7, 2019
Applicant:
Research Institute at Nationwide Children's Hospital
Abstract: Compositions and methods for treating cancer in a subject in need thereof are described that includes administering a therapeutically effective amount of an oligonucleotide that inhibits the binding of splicing regulator SRSF1 or SRSF2 to MDM2 exon 4 or 11.
Type:
Grant
Filed:
May 12, 2017
Date of Patent:
November 5, 2019
Assignee:
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
Inventors:
Dawn Suzan Chandler, Daniel Forrest Comiskey, Jr.