Abstract: Polynucleotides and vectors can be used for the expression of a transgene in cells, such as liver cells. The expression of the transgene from the polynucleotides and vectors can be useful in gene therapy. Various methods can be used for expressing the transgene from the polynucleotides and vectors in liver cells.

Abstract: An orthopaedic device for securing between first and second regions of bone separated by a growth plate, the orthopaedic device comprising: a first portion to secure to a first fixing location on the first bone region; a second portion to secure to a second fixing location on the second bone region, the first fixing location and the second fixing location being laterally offset relative to a longitudinal axis of the bone; wherein the first and second portions are pivotally coupled between a first coupling location on the first portion and a second coupling location on the second portion such that movement of the first and second portions away from each other in a direction parallel to the longitudinal axis of the bone causes relative rotation of the first bone region and the second bone region thereby reducing the lateral offset of the first location and the second location.

Abstract: Provided herein are methods for facilitating or inducing stable transgene integration and expression in a proliferating cell, comprising administering to the cell (i) a recombinant AAV (rAAV) vector comprising the transgene flanked by transposon-derived inverted terminal repeat sequences, which sequences are in turn flanked by AAV-derived inverted terminal repeat regions, and (ii) a source of a transposase that recognises said transposon-derived inverted terminal repeat sequences and directs the genomic integration of the transgene into the genome of the proliferating cell. Also provide are methods and transgene delivery systems for the treatment or prevention of diseases affecting, associated with or characterised by proliferating cells.

Abstract: The present disclosure relates generally to promoters derived from the AAV anti-sense strand, their use in the expression of one or more heterologous coding sequences, and isolated polynucleotides, vectors and recombinant viruses comprising the promoters. The present disclosure also relates to enhancers derived from the AAV anti-sense strand, their use in increasing the expression of one or more heterologous coding sequences, and isolated polynucleotides, vectors and recombinant viruses comprising the enhancers.

Abstract: Polypeptides are encoded by an adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely-related marsupial species. Nucleic acid molecules encode the polypeptides. Vectors can include the nucleic acid molecules, and recombinant AAV virions can include the polypeptides. A chimeric capsid protein can also include an MAAV-EVE1 polypeptide.

Abstract: A bisphosphonate for the treatment of osteonecrosis and/or osteonecrosis dissecans. The drug may further he used to prevent the onset of osteonecrosis and/or osetonecrosis dissecans and any complications associated with both diseases.

Abstract: A bisphosphonate for the treatment of osteonecrosis and/or osteonecrosis dissecans. The drug may further be used to prevent the onset of osteonecrosis and/or osteonecrosis dissecans and any complications associated with both diseases.

Abstract: An optical system (10) comprises a camera (11) having an imaging means that in use faces downwardly, and an optical assembly. The optical assembly includes a support (14) that extends outwardly from the camera (11) and which has a lumen therethrough to allow transmission of light through the support (14) to the imaging means of the camera (11). The assembly further includes an optical unit (16) mountable to the support (14) and movable relative thereto towards and away from the imaging means of the camera (11). The optical unit (16) includes at least one lens (17) and a mirror assembly ( 22, 23) adapted to reflect at least some light entering the unit (16) that is at approximately a right angle to the orientation of the camera (11), through the lens (17) and into the lumen of the support (14) to the imaging means. The system (10) can be mounted to a headpiece worn by a user, such as a surgeon.

Abstract: A surgical training device (10) for the practice of surgical techniques. The device (10) comprises an operation area (18) arranged to receive an operable structure and a screening wall (13) having an aperture (21). The wall (13) is positioned relative to the operation area (18) such that the wall prevents direct viewing of the operation area (18) from at least one position (19) external the wall (18). The device further includes an optical system comprising a first mirror (24) and a second mirror (25). The first mirror (24) is arranged to reflect a primary image of the operation area (18) to the second mirror (25) which in turn is arranged to reflect a secondary image of the operation area (18) that is visible from the external position (19). The position and orientation of the mirrors and the aperture (21) is such that only the secondary image of the operation area (18) is visible from the external position (19).