Patents Assigned to The Salk Insitute for Biological Studies
  • Modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
    Patent number: 6605627
    Abstract: In accordance with the present invention, there is provided a class of compounds which are capable of modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-&ggr;). The identification of such compounds makes it possible to intervene in PPAR-&ggr; mediated pathways.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: August 12, 2003
    Assignee: The Salk Insitute for Biological Studies
    Inventors: Ronald M. Evans, Barry M. Forman
  • Corticotropin-releasing factor overproducing transgenic mice
    Patent number: 6023011
    Abstract: In accordance with the present invention, there are provided CRF overproducing transgenic mice which exhibit endocrine abnormalities involving the hypothalamic-pituitary-adrenal axis, such as elevated plasma levels of ACTH and glucocorticoids. The transgenic mice of the present invention represent a genetic model of CRF overproduction, providing a valuable tool for investigating the long term effects of CRF excess and dysregulation in the central nervous system.
    Type: Grant
    Filed: May 28, 1993
    Date of Patent: February 8, 2000
    Assignee: The Salk Insitute for Biological Studies
    Inventors: Wylie W. Vale, Jr., Mary P. Stenzel-Poore