Abstract: CRF peptide analogs that bind to CRFR2 with an affinity far greater than they bind to CRFR1. These analogs exhibit CRF antagonist activity, and they can be based upon the native structures of sauvagine, CRF, and urocortin.
Type:
Grant
Filed:
July 31, 2002
Date of Patent:
November 28, 2006
Assignee:
The Salk Institute for Biologicial Studies
Inventors:
Jean E. F. Rivier, Wylie W. Vale, Marilyn H. Perrin, Jozsef Gulyas, Dean A. Kirby