Abstract: Described is a method for diagnosing a person having or being at risk of developing Sjögren's Syndrome and excluding patients with symptoms similar to Sjögren's Syndrome but with a different etiology, comprising the following steps: providing a sample of a body fluid or tissue from said person, said sample containing a mixture of unknown proteins, protein fragments or peptides; analyzing said samples with mass spectrometry to generate a m/z (mass to charge ratio) spectrogram for each sample; comparing whether the patient's sample contains m/z values that are characteristic of a Sjögren's Syndrome reference database derived from the analysis and cataloguing of multiple patient spectrograms; and determining whether said patient either has or does not have Sjögren's Syndrome on the basis of this comparative analysis.
Type:
Application
Filed:
November 20, 2006
Publication date:
August 9, 2007
Applicants:
LARGE SCALE BIOLOGY CORPORATION, Trustees of Tufts College, The Schepens Eye Research Institue, Inc.
Inventors:
Kevin Dawson, Wasyl Malyj, William Haddon, Daniel Tuse, Earl White, Driss Zoukhri, Ian Rawe