Patents Assigned to The Scientific Research Foundation
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Publication number: 20100152488Abstract: The present invention relates to high purity (?) Hydroxycitric acid metal salt derivatives of more than 98% purity having formula II (a-e), lla; X, 2X?Na Mb; X, 2X?K Hc; X?K, Y?Ca Hd1 X?Na, Y?Ca He; X=½Mg, Y?Mg and the method of preparation of high purity (?) hydroxycitric acid metal salt derivatives from (?) hydroxycitric acid lactone having formula (1) which in turn is isolated in a simple and efficient manner from dried rinds of the fruits of Garcinia species. This invention employs the HPLC method and optical rotation in assessing the purity (?) hydroxycitric acid and corresponding lactone (1).Type: ApplicationFiled: August 28, 2007Publication date: June 17, 2010Applicant: VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATIONInventors: Gudapati Vendateswara Rao, Alageri Chandrashekara Karunakara, Mullakkapurath Narayanan Manoj, Anil Kumar Kush, Goukanapalli Chandrasekara Reddy
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Patent number: 6852742Abstract: The present invention is directed in part towards methods of modulating the function of calcium channels with pyridine- or 1,4-dihydropyridine-based compounds. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to pyridine- or 1,4-dihydropyridine-based compounds and pharmaceutical compositions comprising these compounds.Type: GrantFiled: January 14, 2003Date of Patent: February 8, 2005Assignee: Vittal Mallya Scientific Research FoundationInventors: Phani Kumar Pullela, Paramashivappa Rangappa, Srinivasa Rao Alapati, Pillarisetti V. Subbarao, Jeffrey A. Bibbs
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Patent number: 6635757Abstract: The present invention relates to a process for the preparation of a water soluble inclusion complex of neem seed kernel extract (NSKE) containing azadirachtin-A in cyclodextrin and its use in an insecticidal formulation. The process of the present invention comprises the following steps adding neem seed kernel extract containing azadirachtin-A to cyclodextrin, the molar ratio of azadirachtin-A to the cyclodextrin ranging from 1:0.5 to 1:20, stirring the above mixture, filtering the above mixture to obtain a water soluble inclusion complex of neem seed kernel extract, if desired, freeze/spray drying the said water soluble complex of neem seed kernel extract to get a free flowing pale cream powder.Type: GrantFiled: September 14, 2001Date of Patent: October 21, 2003Assignee: Vittal Mallya Scientific Research FoundationInventors: Sandeep Prabhu Kumble, Ramaswamy SambasivamAnnadurai, Malladi Srinivas, Alapati Srinivasa Rao, Candadai Seshardi Ramadoss, Pillarisetti Venkata Subba Rao
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Patent number: 6337194Abstract: The invention provides a protein precursor of a double-chain molecule having at least two polypeptide chains linked by two disulfide bonds. The precursor has the general formula B—Z—A wherein B and A are the two insulin polypeptide chains, and Z is a polypeptide comprising at least one site for proteolytic cleavage in a eukaryotic host cell transformed by DNA coding for the protein precursor or in a eukaryotic cell-free system, resulting in a secreted double-chain product consisting of the disulfide-bonded A and B chains in which a portion of the Z polypeptide is retained on the A chain and/or the B chain and can be removed therefrom by enzymatic or chemical agents in vitro. Preferably the B and A polypeptides are, respectively, the B- and A-chains of insulin linked by two disulfide bonds, and the mature insulin molecule is isolatable from the secreted double-chain product.Type: GrantFiled: August 19, 1998Date of Patent: January 8, 2002Assignees: Vittal Mallya Scientific Research Foundation, the University of LeicesterInventors: Christopher Hadfield, Peter A Meacock, Patnam R Krishnaswamy, Kaithamana Shashi, Krisha K Raina, Candadai S Ramadoss
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Patent number: 6160172Abstract: The present invention is directed to a new soluble double metal salt of group IA and IIA of (-) hydroxycitric acid of general formula I:where X is IA group metal: Li or Na or K or Rb or Cs or Frwhere Y is IIA group metal: Be or Mg or Ca or Sr or Ba or Rawhere the concentration of X in the salt varies from 1.5-51.0%,the concentration of Y in the salts varies from 2.0-50.9%,the concentration of HCA in the salt varies from 31.0-93.0% depending on the nature of X and Y.This invention more particularly relates to new soluble double metal salt of group IA and IIA of (-) hydroxycitric acid of general formula II.Type: GrantFiled: April 14, 1998Date of Patent: December 12, 2000Assignee: Vittal Mallya Scientific Research FoundationInventors: Karanam Balasubramanyam, Bhaskaran Chandrasekhar, Candadai Seshadri Ramadoss, Pillarisetti Venkata Subba Rao
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Patent number: 6060075Abstract: This invention relates to a composition for controlling house dust mites. The composition comprises neem seed kernel extract containing azadirachtin, an alcoholic extract of plant resins, plant polyphenols or phenolic compound, fungistat used in food industry and a dispersion medium. The invention further includes a process of preparing the same by dispersing the above ingredients in a dispersion medium.Type: GrantFiled: August 20, 1998Date of Patent: May 9, 2000Assignee: Vittal Mallya Scientific Research FoundationInventors: Pillarisetti Venkata Subba Rao, Ramaswamy Sambasivam Annadurai, Malladi Srinivas
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Patent number: 5665868Abstract: Phosvitin or a modified phosvitin immobilised and coupled to a suitable matrix may be used for the separation and purification of proteins or polypeptides and in the removal of metal ions from biological material. If desired the phosvitin or modified phosvitin may be in the form of a metal chelate complex.Type: GrantFiled: September 13, 1991Date of Patent: September 9, 1997Assignee: Vittal Mallya Scientific Research FoundationInventors: Candadai Seshadri Ramadoss, Hiten Vasant Lakhey, Patnam Rajagopaliengar Krishnaswamy
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Patent number: 5536516Abstract: A process of enriching hyroxycitric acid (HCA) from Garcinia rind in which a salt-free water extract of Garcinia rind is loaded onto an anion exchange column, eluted with a metal hydroxide for release of HCA. The water-extract is then treated with a cation exchange column to make free HCA as a free acid. The water extract is loaded at a capacity of 100 to 125% of the anion exchange column and at a capacity of 50 to 90% of the cation exchange column. The HCA can be added to food products such as beverages and snack bars.Type: GrantFiled: August 24, 1994Date of Patent: July 16, 1996Assignees: Renaissance Herbs, Inc., Vittal Mallya Scientific Research FoundationInventors: Scott A. Moffett, Ashok K. Bhandari, Bhagavathula Ravindranath
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Patent number: 4674477Abstract: A solar collector includes a transparent envelope and an absorber panel extending therethrough, the transparent envelope being constituted of a transparent plastic tube of smaller diameter than the width of the absorber panel such that the absorber panel supports the transparent plastic tube in an oval shape. In the described method of making the solar collector, a transparent plastic sheet is first bent into a right circular cylinder with its longitudinal edges secured together; and then a rigid absorber panel, having a width greater than the diameter of the cylinder, is inserted into the cylinder to deform it into an oval shape.Type: GrantFiled: July 7, 1981Date of Patent: June 23, 1987Assignee: The Scientific Research FoundationInventor: Harry Z. Tabor
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Patent number: 4438952Abstract: A quickly-attachable pipe coupling comprises a flexible tube having an internal diameter approximately equal to the outer diameter of the pipe to be coupled, and a cylindrical spring overlying the flexible tube. The cylindrical spring includes a closely-wound coil of flat spring material having more than one turn, and having an inner diameter in its relaxed condition less than the outer diameter of the flexible tube. The coil spring is partially uncoilable under stress to open by increasing its inner diameter at least to the outer diameter of the flexible tube. Thus, the flexible tube and the cylindrical spring thereover, when in its stressed open condition, may be applied over the end of the pipe to be coupled, whereupon the cylindrical spring may be relaxed to close and to cause it to compress the flexible tube into tight engagement with the pipe for the complete length of the coil spring.Type: GrantFiled: July 7, 1981Date of Patent: March 27, 1984Assignee: The Scientific Research FoundationInventor: Harry Z. Tabor
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Patent number: 4152224Abstract: The invention relates to an additive, to be added to conventional electrolytes of alkaline secondary zinc cells or to alkaline zinc plating baths, adapted to establish in said liquids a minimum concentration of 10.sup.-6 M per liter of cobalt ions and a minimum concentration of 5.10.sup.-6 M per liter of cadmium ions, said additive being a coprecipitate of cobalt hydroxide and cadmium hydroxide and either magnesium hydroxide or calcium hydroxide, to electrolytes for alkaline secondary zinc cells and alkaline zinc plating baths containing such additives and to a process for the production of such additives.Type: GrantFiled: August 22, 1977Date of Patent: May 1, 1979Assignees: State of Israel, Ministry of Industry, Commerce and Tourism, National Physical Laboratory of Israel, The Scientific Research FoundationInventors: Yitzchak Klein, Jonathan G. Goldstein
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Patent number: 4132619Abstract: The invention relates to mixed oxides of the spinel type or of similar structure, containing a quantity of boron adapted to reduce the electrical resistance of the oxide by a factor of at least 1000 calculated on the corresponding compound without boron, some of the preferred compounds being selected from compounds of the formulae Co.sub.x Fe.sub.3-x O.sub.n and Co.sub.x Ni.sub.3-x O.sub.n, wherein x is between 0.05 and 3, n is between 3 and 5, containing from 0.05 to 20 atom per cent boron calculated on the mixed oxides, wherein part of the Co,Ni. or Fe may be substituted by an equivalent quantity of magnesium or calcium, said compounds being optionally doped with lithium; electrocatalytically active electrodes made from such compounds and electrical cells containing such electrodes.Type: GrantFiled: August 2, 1977Date of Patent: January 2, 1979Assignees: State of Israel, Ministry of Industry, Commerce and Tourism, National Physical Laboratory of Israel, The Scientific Research FoundationInventors: Yitzchak Klein, Jonathan R. Goldstein
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Patent number: 4126200Abstract: A vehicle drive system comprising a source of rotational energy, a flywheel, continuously variable transmission apparatus comprising first and second drive terminals, and apparatus for selectable coupling of the variable transmission apparatus and the source of rotational energy to said flywheel and drive wheels in a vehicle and including first apparatus for coupling in a first mode of operation, the flywheel and the source of rotational energy to the first drive terminal, and the second drive terminal to the drive wheels of a vehicle, and second apparatus for coupling in a second mode of operation, the flywheel to the second drive terminal, the rotational energy source and the first drive terminal to the drive wheels, and control apparatus for governing the operation of the continuously variable transmission apparatus and the operation of the source of rotational energy and being capable of independent control of the speed of the flywheel and of the source of rotational energy.Type: GrantFiled: March 3, 1977Date of Patent: November 21, 1978Assignee: The Scientific Research FoundationInventors: Morris L. Miller, Daniel Locker