Patents Assigned to The Scripps Institute
  • Neoseptins: small molecule adjuvants
    Patent number: 9649373
    Abstract: A MD-2:TLR4 complex agonist compound is disclosed whose structure corresponds to Formula (I), as defined within. Also disclosed are a method of its preparation and use, as well as a pharmaceutical composition containing the same.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: May 16, 2017
    Assignees: The Scripps Institute, Board of Regents of the University of Texas Systems
    Inventors: Bruce Beutler, Dale L. Boger
  • Method for treatment and prevention of physiological shock
    Patent number: 6534283
    Abstract: Shock is a life threatening complication in situations associated with trauma including burns, surgery, ischemia, sepsis, and other critical care applications. Shock is induced by pancreatic proteases when they are released into the small intestine when the tissue is compromised due to trauma. Administration of protease inhibitors into the small intestine, either orally, intraveneously, or by direct lavage, was demonstrated to prevent shock in rats as determined by both survival time and molecular and histological analysis.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: March 18, 2003
    Assignees: The Regents of the University of California, The Scripps Institute
    Inventors: Geert Schmid-Schoenbein, Tony Hugli, Hiroshi Mitsuoka