Patents Assigned to The Scripps Research Insitiute
  • PALLADIUM-CATALYZED ORTHO-FLUORINATION
    Publication number: 20120059179
    Abstract: A new method of ortho-fluorination where an aryl C—H bond is directly replaced by an aryl C-F bond in a palladium-catalyzed reaction is provided. The method includes the ortho-fluorination of a triflamide protected benzylamine, a palladium catalyst, such as Pd(OTf)2, a fluorinating reagent such as N-fluoro-2,4,6-trimethylpyridinium triflate, and a ligand to promote the reaction such as N-methylpyrrolidinone (NMP).
    Type: Application
    Filed: April 2, 2010
    Publication date: March 8, 2012
    Applicant: The Scripps Research Insitiute
    Inventor: Jin-Quan Yu