Patents Assigned to THE SECOND MILITARY MEDICAL UNIVERSITY, PLA
  • Indenoquinolone compound, preparation method and use thereof
    Patent number: 9181193
    Abstract: An indenoquinolone compounds of Formula (A) is disclosed, wherein the definition of each group is described in the description. These compounds may specifically inhibit topoisomerase I, and they have good activities against many kinds of human tumor cells, such as lung cancer, colon cancer, breast cancer, liver cancer and the like. They can be used in the manufacture of antitumor drugs. The method for preparing the compound of formula (A), and pharmaceutical compositions containing such compounds and the use in the manufacture of antitumor drugs are also disclosed.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: November 10, 2015
    Assignee: Second Military Medical University, PLA
    Inventors: Yunlong Song, Xiaodan Fu, Yunpeng Qi, Yves G. Pommier
  • INDENOQUINOLONE COMPOUND, PREPARATION METHOD AND USE THEREOF
    Publication number: 20130102598
    Abstract: An indenoquinolone compounds of Formula (A) is disclosed, wherein the definition of each group is described in the description. These compounds may specifically inhibit topoisomerase I, and they have good activities against many kinds of human tumor cells, such as lung cancer, colon cancer, breast cancer, liver cancer and the like. They can be used in the manufacture of antitumor drugs. The method for preparing the compound of formula (A), and pharmaceutical compositions containing such compounds and the use in the manufacture of antitumor drugs are also disclosed.
    Type: Application
    Filed: May 17, 2011
    Publication date: April 25, 2013
    Applicant: SECOND MILITARY MEDICAL UNIVERSITY, PLA
    Inventors: Yunlong Song, Xiaodan Fu, Yunpeng Qi
  • Use of Polypeptide Micromolecule MLIF in Preparing Medicine for Preventing and Treating Myocardial Ischemia
    Publication number: 20120122786
    Abstract: Use of polypeptide micromolecule MLIF in preparing medicine for preventing and treating myocardial ischmia, where amino acid sequence of the polypeptide micromolecule MLIF is Met-Gln-Cys-Asn-Ser (SEQ ID NO:1).
    Type: Application
    Filed: January 23, 2012
    Publication date: May 17, 2012
    Applicant: THE SECOND MILITARY MEDICAL UNIVERSITY, PLA
    Inventors: Yaocheng Rui, Tiejun Li, Pengyuan Yang, Yuefan Zhang