Abstract: A use of sorafenib or regorafenib or an analogue or a derivative thereof in the preparation of pharmaceuticals for treatment of myeloproliferative neoplasms. The myeloproliferative neoplasms are polycythemia vera or myeloproliferative neoplasms having drug resistance.

Abstract: A use of Sorafenib or a derivative thereof in the preparation of a medication for the prevention and/or treatment of type 1 diabetes.

Abstract: Disclosed are methods of using a microRNA-210 inhibitor in preparation of drugs for treating inflammatory skin diseases. The present inventor has demonstrated through a large number of experiments that in vitro inhibition of microRNA-210 expression can significantly enhance the expression of its target gene STAT6, thereby inhibiting proliferation and chemokine CCL20 secretion of keratinocytes, further inhibiting chemotactic T cell migration towards skin lesion, and also inhibiting differentiation of TH1 and TH17. MicroRNA-210 knockout and intradermal injection of a microRNA-210 inhibitor (cholesterol-modified antagomiR-210) on a skin lesion specifically inhibit the expression of microRNA-210, so that skin inflammation in mice can be significantly inhibited, and T cell immune imbalance is mitigated. The present invention provides a new pathophysiological mechanism for inflammatory skin diseases and provides a new strategy for preparing drugs for treating inflammatory skin diseases.

Abstract: A series of bone remodeling regulatory peptides and application thereof are disclosed. Through sequence alignment, structure analysis, physical and chemical properties and function prediction, a series of bone remodeling regulatory peptides are designed and synthesized by solid-phase peptide synthesis method: Core peptide sequence: Gly-Xaa-Pro-Gly-Xaa-Xaa-Gly-Xaa-Xaa, A1-1: Gly-Ala-Pro-Gly-Pro-Gln-Gly-Phe-Gln, A1-2-1: Gly-Ala-Pro-Gly-Ala-Pro-Gly-Ser-Gln, A1-4-1: Gly-Pro-Pro-Gly-Pro-Ala-Gly-Phe-Ala, A1-5-3: Gly-Pro-Pro-Gly-Ala-Thr-Gly-Phe-Pro, and OSCpep: Gly-Ala-Pro-Gly-Pro-Ala-Gly-Phe-Ala. These peptides have the features of short length, simple synthesis, low cost, low cytotoxicity, high biological stability, moderate half-life, good bone targeting. They can regulate the differentiation and function of osteoclasts and osteoblasts by adjusting the concentration, thereby achieving the orderly regulation of bone resorption and bone formation, and have wide potential application prospects.

Abstract: A microelectronic controlled magnetic cleaning system, comprising a micron-scale fine line inner-end part, a micro-scale fine line outer motor control part, and a micro-scale fine line outer system electronic control part. The micron-scale fine line inner-end part is manufactured as a plurality of micron-scale magnetic fine lines, wherein the central magnetic fine lines are slightly wider than the periphery magnetic fine lines. The inner-end part of the central magnetic fine lines is spiral shaped. The micro-scale fine line outer motor control part is made by adding a high-precision micro-motor at the middle portion outside the central magnetic fine lines, When a larger obstruction is found by an endoscope or other optical device imaging system, the central magnetic fine lines can be controlled to arrive at a designated position, and motor speed can be controlled to clean the obstruction. Also disclosed is a micro-electronic controlled magnetic cleaning method.

Abstract: The present invention provides an application of lncRNAs ENST00000607393 siRNA in preparing a preparation for treating glaucoma. The present invention clarifies the correlation between the expression level of ENST00000607393 and the calcification of human primary trabecular meshwork cells. The expression level of ENST00000607393 in human primary trabecular meshwork cells is firstly down-regulated to 46.21% of a control group by siRNA interference. Under the condition of intervening with the cells by a 500 ?mol/L hydrogen peroxide solution for 48 hours, it is observed that compared with the control group, the down-regulation of ENST00000607393 expression can significantly decrease the ALP activity in human primary trabecular meshwork cells, and thus significantly decrease the calcification level of human primary trabecular meshwork cells to play a role of treating or preventing glaucoma.

Abstract: Disclosed are methods of using a microRNA-210 inhibitor in preparation of drugs for treating inflammatory skin diseases. The present inventor has demonstrated through a large number of experiments that in vitro inhibition of microRNA-210 expression can significantly enhance the expression of its target gene STAT6, thereby inhibiting proliferation and chemokine CCL20 secretion of keratinocytes, further inhibiting chemotactic T cell migration towards skin lesion, and also inhibiting differentiation of TH1 and TH17. MicroRNA-210 knockout and intradermal injection of a microRNA-210 inhibitor (cholesterol-modified antagomiR-210) on a skin lesion specifically inhibit the expression of microRNA-210, so that skin inflammation in mice can be significantly inhibited, and T cell immune imbalance is mitigated. The present invention provides a new pathophysiological mechanism for inflammatory skin diseases and provides a new strategy for preparing drugs for treating inflammatory skin diseases.

Abstract: The present invention provides two molecular markers, lncRNAs ENST00000607393 and lncRNAs ENST00000508241, diagnostic kits and applications for glaucoma diagnosis. Compared with people in a control group, the expressions of lncRNAs: ENST00000607393 are all up-regulated in aqueous humors, irises and serums of patients with glaucoma, and the expression of lncRNAs: ENST00000508241 is up-regulated in aqueous humors of patients with glaucoma. It indicates that ENST00000607393 and ENST00000508241 are highly expressed lncRNAs in glaucoma and are biomarkers that contribute to the diagnosis of glaucoma. The present invention provides a strong molecular biology basis for the diagnosis of glaucoma, and has far-reaching clinical significance and generalization performance.

Abstract: A gyroscope-based system and method is disclosed. Image information data is collected; a mechanical arm working environment image is modeled; a heat source supply apparatus and a gyroscope are provided at the mechanical arm proximal end; the position of the proximal end is accurately measured by accurately tracking the heat source at the proximal end; the relative position of the mechanical arm distal end is accurately calculated by using high-precision angle information measured by the high-precision gyroscope in combination with a number-theoretic formula. The disclosure provides separately determining the position of the distal end, or for assisting other algorithms or apparatuses that track the position of the mechanical arm distal end in error correction and calibration of the position of the mechanical arm distal end. The position of the mechanical arm distal end can be continuously and dynamically tracked in real time, and virtualized in the corresponding image system.

Abstract: The present invention provides an application of lncRNAs ENST00000607393 siRNA in preparing a preparation for treating glaucoma. The present invention clarifies the correlation between the expression level of ENST00000607393 and the calcification of human primary trabecular meshwork cells. The expression level of ENST00000607393 in human primary trabecular meshwork cells is firstly down-regulated to 46.21% of a control group by siRNA interference. Under the condition of intervening with the cells by a 500 ?mol/L hydrogen peroxide solution for 48 hours, it is observed that compared with the control group, the down-regulation of ENST00000607393 expression can significantly decrease the ALP activity in human primary trabecular meshwork cells, and thus significantly decrease the calcification level of human primary trabecular meshwork cells to play a role of treating or preventing glaucoma.

Abstract: The present invention relates to the use of N-(2-aminoethyl)-N-(4-benzyloxy)-3-methoxybenzyl)thiophene-2-formamide hydrochloride for treating liver cancer. The N-(2-aminoethyl)-N-(4-benzyloxy)-3-methoxybenzyl)thiophene-2-formamide hydrochloride of the present invention can effectively inhibit the growth of liver cancer cells and has a therapeutic effect on liver cancer.

Abstract: The present invention discloses three molecular markers kits and applications for glaucoma diagnosis. The expressions of lncRNAs: T342877, lncRNAs: NR_026887, and lncRNAs: TCONS_00025577 are up-regulated in aqueous humors of patients with glaucoma compared with people in a control group. It indicates that lncRNAs: T342877, lncRNAs: NR_026887, and lncRNAs: TCONS_00025577 are highly expressed lncRNAs in glaucoma and are biomarkers that contribute to the diagnosis of glaucoma. The present invention provides a strong molecular biology basis for the diagnosis of glaucoma, and has far-reaching clinical significance and generalization performance.

Abstract: The present invention discloses two molecular markers, kits and applications for glaucoma diagnosis. Compared with people in a control group, the expressions of lncRNAs: T267384 are all up-regulated in aqueous humors and serums of patients with glaucoma, and the expression of lncRNAs: ENST00000564363 is up-regulated in aqueous humors of patients with glaucoma. It indicates that T267384 and ENST00000564363 are highly expressed lncRNAs in glaucoma and are biomarkers that contribute to the diagnosis of glaucoma. The present invention provides a strong molecular biology basis for the diagnosis of glaucoma, and has far-reaching clinical significance and generalization performance.

Abstract: A microelectronic controlled magnetic cleaning system, comprising a micron-scale fine line inner-end part, a micro-scale fine line outer motor control part, and a micro-scale fine line outer system electronic control part. The micron-scale fine line inner-end part is specifically manufactured as a plurality of micron-scale magnetic fine lines, wherein the central magnetic fine lines are slightly wider than the periphery magnetic fine lines. The inner-end part of the central magnetic fine lines is spiral shaped. The micro-scale fine line outer motor control part is made by adding a high-precision micro-motor at the middle portion outside the central magnetic fine lines, When a larger obstruction is found by an endoscope or other optical device imaging system, the central magnetic fine lines can be controlled to arrive at a designated position, and motor speed can be controlled to clean the obstruction.

Abstract: A gyroscope-based system and method is disclosed. Image information data is collected; a mechanical arm working environment image is modeled; a heat source supply apparatus and a gyroscope are provided at the mechanical arm proximal end; the position of the proximal end is accurately measured by accurately tracking the heat source at the proximal end; the relative position of the mechanical arm distal end is accurately calculated by using high-precision angle information measured by the high-precision gyroscope in combination with a number-theoretic formula. The disclosure provides separately determining the position of the distal end, or for assisting other algorithms or apparatuses that track the position of the mechanical arm distal end in error correction and calibration of the position of the mechanical arm distal end. The position of the mechanical arm distal end can be continuously and dynamically tracked in real time, and virtualized in the corresponding image system.

Abstract: The present invention relates to the use of N-(2-aminoethyl)-N-(4-benzyloxy)-3-methoxybenzyl)thiophene-2-formamide hydrochloride for treating liver cancer. The N-(2-aminoethyl)-N-(4-benzyloxy)-3-methoxybenzyl)thiophene-2-formamide hydrochloride of the present invention can effectively inhibit the growth of liver cancer cells and has a therapeutic effect on liver cancer.

Abstract: The present invention relates to a molecular marker, a kit and an application for early diagnosis and prediction of sepsis acute kidney injury (AKI). TCONS_00024536 is highly expressed in the blood of sepsis AKI patients. By detecting the expression level of TCONS_00024536 in the blood of patients, whether the patients suffer from sepsis AKI or the probability of suffering from sepsis AKI can be judged. The present invention is of great significance for specific and sensitive early diagnosis and prediction of sepsis AKI.