Patents Assigned to The Simons Foundation, Inc.
  • Systems and methods for targeting cancer cells
    Patent number: 12466892
    Abstract: The present disclosure provides immune cells genetically modified to produce two antigentriggered polypeptides, each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. The present disclosure further provides systems comprising two antigen-triggered polypeptides (or nucleic acids encoding same), each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. Also provided are method of killing a target cancer cell, using the described genetically modified immune cells and/or systems. The present disclosure also provides poly specific-immune inducing polypeptides including first and second antigen binding domains specific for first and second antigens, respectively, present on the surface of a target cancer cell.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: November 11, 2025
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE TRUSTEES OF PRINCETON UNIVERSITY, THE SIMONS FOUNDATION, INC.
    Inventors: Wendell A. Lim, Olga G. Troyanskaya, Benjamin Vandersluis, Ruth Dannenfelser
  • Systems and Methods for Analyzing Genetic Data for Assessment of Gene Regulatory Activity
    Publication number: 20250182843
    Abstract: Processes that determine transcriptional regulation from genetic sequence data are described. Generally, computational models are trained to predict transcriptional regulatory effects, which can be used in several downstream applications. Various methods further develop research tools, develop and perform diagnostics, and treat individuals based on identified variants.
    Type: Application
    Filed: June 21, 2022
    Publication date: June 5, 2025
    Applicants: The Trustees of Princeton University, The Simons Foundation, Inc., The Board of Regents of The University of Texas System
    Inventors: Olga G. Troyanskaya, Kathleen Chen, Jian Zhou
  • Methods for predicting genomic variation effects on gene transcription
    Patent number: 12176068
    Abstract: Processes to determine the effect of genetic sequence on gene expression levels are described. Generally, models are used to determine spatial chromatin profile from genetic sequence, which can be used in several downstream applications. The effect of the spatial chromatin profile on gene expression is also determined in some instances. Various methods further develop research tools, perform diagnostics, and treat individuals based on sequence effects on gene expression levels.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: December 24, 2024
    Assignees: The Trustees of Princeton University, The Simons Foundation, Inc.
    Inventors: Jian Zhou, Chandra Theesfeld, Olga G. Troyanskaya
  • Methods for Analyzing Genetic Data to Classify Multifactorial Traits Including Complex Medical Disorders
    Publication number: 20210074378
    Abstract: Processes to identify variants that affect biochemical regulation are described. Generally, models are used to identify variants that affect biochemical regulation, which can be used in several downstream applications. A pathogenicity of identified variants is also determined in some instances, which can also be used in several. Various methods further develop research tools, perform diagnostics, and treat individuals based on identified variants.
    Type: Application
    Filed: January 28, 2019
    Publication date: March 11, 2021
    Applicants: The Trustees of Princeton University, The Simons Foundation, Inc., The Rockefeller University
    Inventors: Jian Zhou, Christopher Y. Park, Chandra Theesfeld, Robert B. Darnell, Olga G. Troyanskaya
  • Methods for Predicting Genomic Variation Effects on Gene Transcription
    Publication number: 20210027855
    Abstract: Processes to determine the effect of genetic sequence on gene expression levels are described. Generally, models are used to determine spatial chromatin profile from genetic sequence, which can be used in several downstream applications. The effect of the spatial chromatin profile on gene expression is also determined in some instances. Various methods further develop research tools, perform diagnostics, and treat individuals based on sequence effects on gene expression levels.
    Type: Application
    Filed: March 26, 2019
    Publication date: January 28, 2021
    Applicants: The Trustees of Princeton University, The Simons Foundation, Inc.
    Inventors: Jian Zhou, Chandra Theesfeld, Olga G. Troyanskaya