Abstract: This invention relates to an animal model for human ocular disease, particularly glaucoma. The invention provides methods for determining the causes of human ocular diseases, and specifically provides methods for the anatomical, histochemical and molecular biological evaluation of the effects of elevated intraocular pressure on various tissues in mammalian eyes in vivo. The invention also provides methods for non-invasively measuring intraocular pressure and for evaluating the efficacy of treatment stategies for glaucoma involving glaucoma-relieving drugs.

Abstract: Disclosed herein is purified isolated angiogenic factor, isolated from Live Yeast Cell Derivitive. Also disclosed herein are methods to treat mammals suffering from wounds or burns comprising administering the angiogenic factor and pharmaceutical formulations for use in the methods.

Abstract: An improved method for diagnosing and characterizing brain lesions is described which first involves chemically modifying the blood-brain barrier (BBB) in order to increase BBB permeability. Thereafter, a chemical agent (e.g. monoclonal antibody) is introduced which binds directly, specifically and exclusively to brain lesons. The chemical has a label attached thereto (e.g. gadolinium-DTPA). The chemical agent and label localize in regions of brain lesion proliferation. Thereafter, the brain is quantitatively analyzed to determine the amount of labeling agent present, preferably using magnetic resonance imaging techniques. This procedure enables the accurate analysis of brain lesions, and represents an advance in the art of diagnostic imaging.