Patents Assigned to The State of Oregon Acting by and Through The State Board of Education on Behalf of The Oregon Health Sciences University
  • Method to assess the ability of a substance to inhibit or stimulate keratinocyte autocrine factor production
    Patent number: 5262298
    Abstract: Keratinocyte autocrine factor (KAF) can be isolated from human keratinocytes and is an effective and selective mitogen for keratinocytes in comparison to fibroblasts. Methods of purifying KAF using sulfated glycosaminoglycans, methods to inhibit the effect of KAF using sulfated glycosaminoglycans, and methods to assay for stimulators and inhibitors of KAF activity and production are described.
    Type: Grant
    Filed: July 26, 1990
    Date of Patent: November 16, 1993
    Assignee: The State of Oregon Acting by and Through the State Board of Education on Behalf of the Oregon Health Sciences University
    Inventors: Gary D. Shipley, Mark R. Pittelkow, Paul W. Cook
  • CNQX and its analogs as therapeutics for degenerative neural diseases
    Patent number: 4975430
    Abstract: Compounds of the formula ##STR1## wherein each X is independently nitro or cyano and wherein each Y is independently H, lower alkyl (1-4C), lower alkoxy (-4C), or CF.sub.3 have been shown to be successful antagonists of NMDA receptors. Accordingly, these compounds are useful in the treatment of neuronal conditions associated with stimulation of the NMDA receptor.
    Type: Grant
    Filed: June 16, 1989
    Date of Patent: December 4, 1990
    Assignee: The State of Oregon Acting by and Through The State Board of Education on Behalf of The Oregon Health Sciences University
    Inventors: Craig E. Jahr, Robin Lester, Eckard Weber