Abstract: The invention provides a topoisomerase poison of formula I:
wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof.
Type:
Grant
Filed:
January 14, 2000
Date of Patent:
April 24, 2001
Assignee:
The State of University of New Jersey, Rutgers
Inventors:
Edmond J. LaVoie, Jung Sun Kim, Meera Rangarajan, Leroy Fong Liu
Abstract: This invention relates to a new class of piezoelectric composites with a radial design. More particularly, the radial design of these new ceramic/polymer composites show a higher sensitivity in the radial direction than conventional tube structured devices. Devices made utilizing this novel design will therefore show significantly enhanced performance in many applications.
Type:
Grant
Filed:
July 13, 1998
Date of Patent:
April 11, 2000
Assignee:
The State University of New Jersey Rutgers
Inventors:
Ahmad Safari, Stephen C. Danforth, Amit Bandyopadhyay, Thomas McNulty, Rajesh K. Panda
Abstract: This invention provides methods for obtaining a plant cell of a multicellular plant, the plastids of which cell have been stably transformed by a foreign DNA of interest. These methods employ selectable markers some of which are nonlethal, some of which are designed to insert into the plastid genome and some of which are designed to be expressible only from the plastid genome and not from the nuclear genome. This invention also provides cells and multicellular plants the plastids of which have been stably transformed by a foreign DNA of interest.
Type:
Grant
Filed:
August 25, 1993
Date of Patent:
September 19, 1995
Assignee:
The State University of New Jersey Rutgers