Abstract: Patient-specific 3D complex coils and methods of making and using such coils, including custom fixtures for the manufacture of such coils. Such patient-specific 3D complex coils improve treatment outcomes for cerebral aneurysm repair. The aneurysm may be an aneurysm in a specific patient and/or population of patients having a similar aneurysm shape and size.

Abstract: A system and method for modulating optogenetic vagus neurons in a noninvasive and transcutaneous manner is disclosed. The system and method comprises a two-dimensional array of organic light emitting diodes (OLEDs), a voltage-generating unit, a control unit, and a feedback loop. The array is placed on a subject's outer ear. Because the array is flexible, it can be closely placed on the skin of the outer ear. The array can deliver optical therapy and monitor heart rate variability (HRV) of the subject simultaneously, and the pixels of the array can be individually addressed. The voltage-generating unit generates pulsed voltage to the OLEDs. The control unit is connected to the array and controls the array and therapeutic patterns. The feedback loop uses the HRV to identify the therapeutic patterns.

Abstract: Solvent free epoxy system that includes: a hardener compound H comprising: a molecular structure (Y1—R1—Y2), wherein R1 is an ionic moiety Y1 is a nucleophilic group and Y2 nucleophilic group; and an ionic moiety A acting as a counter ion to R1; and an epoxy compound E comprising: a molecular structure (Z1R2—Z2), wherein R1 is an ionic moiety, Z1 comprises an epoxide group, and Z2 comprises an epoxide group; and an ionic moiety B acting as a counter ion to R2. In embodiments, the epoxy compound E and/or the hardener H is comprised in a solvent-less ionic liquid. The systems can further include accelerators, crosslinkers, plasticizers, inhibitors, ionic hydrophobic and/or super-hydrophobic compounds, ionic hydrophilic compounds, ionic transitional hydrophobic/hydrophilic compounds, biological active compounds, and/or plasticizer compounds. Polymers made from the disclosed epoxy systems and their methods of used.

Abstract: In one embodiment an optoelectronic system can include a photonics interposer having a substrate and a functional interposer structure formed on the substrate, a plurality of through vias carrying electrical signals extending through the substrate and the functional interposer structure, and a plurality of wires carrying signals to different areas of the functional interposer structure. The system can further include one or more photonics device integrally formed in the functional interposer structure, and one or more prefabricated component attached to the functional interposer structure.

Abstract: The present disclosure provides methods of treating diabetic retinopathy and ocular inflammatory diseases with anti-ceramide antibodies and antibody fragments.

Abstract: Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially stimulate different nerve fiber types and drive different functional responses in the target organs. The stimulation parameters that may vary between the different stimulation therapies include, for example, pulse frequency, pulse width, pulse amplitude, and duty cycle.

Abstract: Various embodiments disclosed relate to visually transparent UV-absorbing coatings including ZnO nanoparticles. The coating includes ZnO nanoparticles, hydroxy(C1-C10)alkyl cellulose, a dispersant, and less than about 5 wt % water.

Abstract: Systems and methods for generating and tracking molecular digital signatures to ensure authenticity and integrity of NA molecules are disclosed. In some embodiments, a NA authentication system includes a NA authentication device coupled to one or more user devices. Methods for generating a signed NA sequence, validating a signed NA sequence, and detecting/correcting potential errors within a user allowable limit using a NA authentication system are disclosed.

Abstract: A method is disclosed for making palatable methionine-restricted foods, to deliver a methionine-restricted diet to human or veterinary patients. A protein or a food product containing protein is partially oxidized, preferably with ozone, to oxidize nearly all of the methionine and cysteine. After oxidation, tryptophan and lysine are optionally added back since they tend to be oxidized also. Optionally, a small amount of methionine is also added back so that the final methionine is within a preferred range of about 0.85 to about 1.8 gram methionine per 100 gram total protein, preferably about 1.2 gram per 100 gram total protein.

Abstract: A hybrid propulsion system includes a housing, at least two electrodes, a solid-grain fuel material, a combustion chamber, an oxidizer port, and a nozzle. The housing has a first end and a second end and defines a cavity. The electrodes extend into the cavity. The fuel material is free of an oxidizer and is positioned in the cavity. The fuel material has a combustion surface and is exposed to the electrodes. The combustion chamber is defined between the combustion surface and the second end. The oxidizer port provides a flow of oxidizer to the combustion chamber. The nozzle is positioned at the second end. Combustion of the fuel material in the combustion chamber may be dominated by radiative heat transfer. Combustion of the fuel material in the combustion chamber may generate thrust of no more than 5 N at an oxidizer flow rate of no more than 5 g/s.

Abstract: Quantum network devices, systems, and methods are provided to enable long-distance transmission of quantum bits (qubits) for applications such as Quantum Key Distribution (QKD), entanglement distribution, and other quantum communication applications. Such systems and methods provide for separately storing first, second, third, and fourth photons, wherein the first and second photons and the third and fourth photons are respective first and second entangled photon pairs, triggering a synchronized retrieval of the stored first, second, third, and fourth photons such that the first photon is propagated to a first node, the second and third photons are propagated to a second node, and the fourth photon is propagated to a third node, and creating a new entangled pair comprising the first and fourth photons at the first and third nodes to transmit quantum information.

Abstract: The present invention relates to a compound having the structure of formula (I), wherein R1, R2, R3, R4, R5, R6, and R7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.

Abstract: Provided are multiply functional telodendrimers. The telodendrimers can be used for combination drug delivery. The telodendrimers may have one or more crosslinking groups (e.g., reversible photocrosslinking groups). The telodendrimers can aggregate to form nanocarriers. Cargo such as combinations of drugs, imaging probes, and other materials may be sequestered in the core of the aggregates via non-covalent or covalent interactions with the telodendrimers. Such nanocarriers may be used in drug delivery applications and imaging applications.

Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.

Abstract: Certain embodiments herein relate to educational knee joint models with synthetic medial and lateral menisci disposed thereon. In certain implementations, one of the synthetic menisci has specific type of tear formed therein. Other embodiments relate to educational knee joint treatment platforms having a base, an attachment wall, a coupling component, and a retention strap.

Abstract: Methods of forming composite materials, which may include filament winding two or more carbon nanotube yarns to form one or more material layers, contacting the yarns with a resin, and applying one or more stretching forces to the material layers. Composite materials also are provided.

Abstract: Guidewires useful for cooperating with catheters may be actively steered and/or provide adjustable stiffness. Angle or curvature of a guidewire, and/or flexural modulus of a guidewire, may be adjusted at one or more locations between ends thereof. Variable stiffness segments may include electrically operated compressible and/or extensible materials. Multiple tensile elements may terminate at different body elements to adjust angle or curvature at multiple locations. Multiple circumferentially and/or radially contractible fiber regions may be provided and distributed over a length of a guidewire. Adjustable flexure elements arranged in or along a guidewire may be electrically operated. A flexible core member may be centrally arranged in a tubular body. A flexible guide wire or track may cooperate with electrically operable motor units.

Abstract: A laser pulse includes a flat top shape. Another aspects provides a method and system for creating laser pulse amplification with a flat top and/or square shape, by only using phase modulation. In yet another aspect, a method and system create a flat top and/or square-shaped laser pulse in a reversible manner such that the stretched spectrum can be recompressed to their original duration with essentially no loss of pulse energy. A further aspect includes a method of making a fixed optic capable to creating flat top or square pulse amplification.

Abstract: Devices, including wireless temperature sensors, are provided. The devices may include a patch including a conductive material, a substrate, and a ground plane. The devices may be used in the systems and methods provided herein to measure a temperature. The substrates of the devices may include a dielectric material.

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I).