Patents Assigned to The State University
  • Plasma HS levels as biomarkers for vascular disease
    Patent number: 9599602
    Abstract: Hydrogen sulfide (H2S) levels in plasma are useful in diagnosing cardiovascular disease. The ratio of H2S to NO in plasma is useful in diagnosing peripheral artery disease.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: March 21, 2017
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Christopher G. Kevil, Elvis A. Peter, Xinggui Shen
  • Therapeutic compounds and methods
    Patent number: 9598441
    Abstract: The invention provides compounds of formula I: and salts thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating cancer using compounds of formula I.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: March 21, 2017
    Assignees: Wayne State University, Regents of the University of Michigan, Department of Veteran Affairs
    Inventors: Arun K. Rishi, Scott D. Larsen
  • Recombinant bacterium to decrease tumor growth
    Patent number: 9598697
    Abstract: A recombinant bacterium capable of reducing tumor growth is provided, wherein said recombinant bacterium is capable of: a. increased expression of a nucleic acid encoding a chemoreceptor that directs chemotaxis towards tumors, b. accumulation in a quiescent tumor, c. hyper-invasion of a tumor, d. reduced fitness in normal tissue, e. enhanced stimulation of the host innate immune responses, f. delivering a tumor specific DNA vaccine vector to a tumor cell, and g. increased bacterium-induced host programmed cell death.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: March 21, 2017
    Assignee: The Arizona Board of Regents for and on Behalf of Arizona State University
    Inventors: Roy Curtiss, III, Wei Kong
  • Tobacco inbred and hybrid plants and tobacco products made thereof
    Patent number: 9596824
    Abstract: The present disclosure provides tobacco inbred plants NC1209-23 SRC, CMS NC1209-23 SRC, DH19 SRC, DH98-325-5 SRC, NC1426-11 SRC, CMS NC1426-11 SRC, and NC1426-17 SRC, and hybrids NC 3 SRC, NC 6 SRC, and NC 4 SRC. The present disclosure also provides parts of such plants, cured tobacco, and tobacco products made from those parts. The present disclosure also includes progenies of the provided plants including hybrids.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 21, 2017
    Assignee: North Carolina State University
    Inventors: Ramsey S. Lewis, Ralph E. Dewey
  • Systems and methods for improving processor efficiency through caching
    Patent number: 9600418
    Abstract: Certain embodiments herein relate to using tagless access buffers (TABs) to optimize energy efficiency in various computing systems. Candidate memory references in an L1 data cache may be identified and stored in the TAB. Various techniques may be implemented for identifying the candidate references and allocating the references into the TAB. Groups of memory references may also be allocate to a single TAB entry or may be allocated to an extra TAB entry (such that two lines in the TAB may be used to store L1 data cache lines), for example, when a strided access pattern spans two consecutive L1 data cache lines. Certain other embodiments are related to data filter cache and multi-issue tagless hit instruction cache (TH-IC) techniques.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: March 21, 2017
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: David Whalley, Hans Magnus Sjalander, Alen Bardizbanyan, Per Larsson-Edefors, Peter Gavin
  • Production of extracellular matrix, conditioned media and uses thereof
    Patent number: 9598672
    Abstract: Provided is a matrix for promoting survival and differentiation of cells transplanted thereon, comprising a base matrix and a cell-made matrix thereon. Methods and means for making and using same are also provided. Also provided are conditioned media, related compositions, related methods, and related packaging products.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: March 21, 2017
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Ilene Sugino, Marco Zarbin, Qian Sun, Raymond B. Birge
  • Method to increase the yield of products in plant material
    Patent number: 9598707
    Abstract: A method to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: March 21, 2017
    Assignee: Arkansas State University-Jonesboro
    Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang
  • Joint angle tracking with inertial sensors
    Patent number: 9597015
    Abstract: A method for estimating joint angles of a multi-segment limb from inertial sensor data accurately estimates and tracks the orientations of multiple segments of the limb as a function of time using data from a single inertial measurement unit worn at the distal end of the limb. Estimated joint angles are computed from measured inertial data as a function of time in a single step using a nonlinear state space estimator. The estimator preferably includes a tracking filter such as an unscented Kalman filter or particle filter. The nonlinear state space estimator incorporates state space evolution equations based on a kinematic model of the multi-segment limb.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: March 21, 2017
    Assignee: Portland State University
    Inventors: James Nathan McNames, Mahmoud El-Gohary, Sean Christopher Pearson
  • Pyridine-oxyphenyl coordinated iridium (III) complexes and methods of making and using
    Patent number: 9598449
    Abstract: Iridium (III) complexes are described together with methods to prepare and use such complexes. Also described are devices that utilize the iridium (III) complexes.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: March 21, 2017
    Assignee: ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Jian Li, Eric Turner, Nathan J. Bakken
  • Use of genes and proteins for peptide production
    Patent number: 9598686
    Abstract: The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: March 21, 2017
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Heather E. Hallen-Adams, John S. Scott-Craig, Jonathan D. Walton, Hong Luo
  • Indolyl or indolinyl hydroxamate compounds
    Patent number: 9598364
    Abstract: Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: March 21, 2017
    Assignees: Taipei Medical University, Ohio State University, National Taiwan University
    Inventors: Ching-Shih Chen, Jing-Ping Liou, Hsing-Jin Liu, Kuo-Sheng Hung, Pei-Wen Shan, Wen-Ta Chiu, Che-Ming Teng
  • Endoscope for analyte consumption rate determination with single cell resolution for in vivo applications
    Patent number: 9597026
    Abstract: Novel methods and devices including modified endoscopes that employ fiber optic technology and multiple extrinsic optical sensors for enablement of simultaneous determination of change rates of biological analytes in vivo with single-cell resolution. The devices employ dynamic oscillatory actuation to determine the gradient of analytes of interest along one or multiple directions with respect to the cell. The change rate or flux of the analyte of interest can be easily determined by applying the first Fick's law that relates the flux with the concentration gradient. The dual operation mode of the device markedly increases measurement sensitivity and accuracy.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: March 21, 2017
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Deirdre Meldrum, Laimonas Kelbauskas, Jeff Houkal, Roger Johnson, Yanqing Tian, Cody Youngbull
  • Photo-induced phase transfer of luminescent quantum dots
    Patent number: 9598635
    Abstract: A method for the photo-mediated phase transfer of inorganic nanocrystals, such as luminescent quantum dots, QDs, is provided. Irradiation, specifically UV excitation (?ex<400 nm), promotes the in-situ ligand exchange of hydrophobic quantum dots with hydrophilic ligands and their facile transfer to polar solvents and buffer media. The technique enables transfer of quantum dots and other nanocrystal materials from hydrophobic to polar and hydrophilic solutions.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: March 21, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Igor Alabugin, Goutam Palui, Tommaso Avellini
  • Surface treatments for vascular stents and methods thereof
    Patent number: 9597434
    Abstract: Surface modified medical devices with nanotubes and polyelectrolyte multilayers, methods of promoting endothelialization, and methods of modifying a medical device surface are disclosed. Nanotubes may be formed on the surface of the medical device and may further be coated with polyelectrolyte multilayers of a polycation and a polyanion. The surface modification is characterized by a nanopattern on the surface of the medical device, with biomimetic properties.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 21, 2017
    Assignee: Colorado State University Research Foundation
    Inventors: Matthew Kipper, Ketul Popat, Melissa Reynolds, Victoria Leszczak, Raimundo Romero
  • Method and system for automatic tool position determination for minimally-invasive surgery training
    Patent number: 9601025
    Abstract: The present invention may be embodied as a method of minimally-invasive surgery (“MIS”) training using a video of an MIS comprising the steps of providing a processor, a display, and a first input device. The method comprises the step of processing the video using the processor to determine a location of the first surgical tool in each of the frames, determining whether the configuration of the first input device substantially corresponds to the location of the first surgical tool in each frame of the video while the video is displayed. The present invention may be embodied as a system for MIS training. The system comprises a processor, a communication device, and a first input device in communication with the processor. The processor is programmed perform any or all of the described disclosed methods.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: March 21, 2017
    Assignees: Health Research, Inc., The Research Foundation for The State University of New York
    Inventors: Thenkurussi Kesavadas, Khurshid Guru
  • Tobacco inbred and hybrid plants and tobacco products made thereof
    Patent number: 9596822
    Abstract: The present disclosure provides tobacco inbred plants NC174 SRC, CMS NC174 SRC, NC821-11 SRC, NC775 Bmr/Bmr SRC, CMS NC775 Bmr/Bmr SRC, NC645 Bmr/Bmr SRC, and hybrids NC 5 SRC and NC 8 SRC. The present disclosure also provides parts of such plants and cured tobacco and tobacco products made from those parts. The present disclosure also includes progenies of the provided plants including hybrids.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 21, 2017
    Assignee: North Carolina State University
    Inventors: Ramsey S. Lewis, Ralph E. Dewey
  • Therapeutic and diagnostic method for ataxia-telangiectasia
    Patent number: 9599626
    Abstract: ATM kinase is shown to regulate proteasome-mediated protein turnover through suppression of the expression of the ubiquitin-like protein ISG15 (Interferon Stimulated Gene 15). Silencing of the ISG15 pathway restored both the ubiquitin and autophagy pathways, and the UV-mediated degradation of their substrates in A-T cells. The ATM kinase negatively regulates the ISG15 pathway, and the constitutively elevated ISG15 pathway induces proteinopathy in A-T cells, and in A-T patients. These findings indicate that proteasome-mediated protein degradation is impaired in A-T cells due to elevated expression of the ISG15 conjugation pathway, which contributes to progressive neurodegeneration in A-T patients. The ISG15 pathway is a new target for both detection and treatment of A-T Inhibitors if ISG15 expression can be used to inhibit or attenuate neurodegeneration in A-T patients.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: March 21, 2017
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventor: Shyamal D. Desai
  • Tobacco inbred and hybrid plants and tobacco products made thereof
    Patent number: 9596823
    Abstract: The present disclosure provides tobacco inbred plants Banket A1 SRC, CMS Banket A1 SRC, NC 2000 SRC, CMS NC 2000 SRC, NC 2002 SRC, CMS NC 2002 SRC, Burley 21 SRC, and CMS Burley 21 SRC. The present disclosure also provides parts of such plants and cured tobacco and tobacco products made from those parts. The present disclosure also includes progenies of the provided plants including hybrids.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 21, 2017
    Assignee: North Carolina State University
    Inventors: Ramsey S. Lewis, Ralph E. Dewey
  • Microbial nanowires and methods of making and using
    Patent number: 9601227
    Abstract: Electrically conductive nanowires, and genetically or chemically modified production and use of such nanowires with altered conductive, adhesive, coupling or other properties are described. The disclosed nanowires are used as device or device components or may be adapted for soluble metal remediation.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: March 21, 2017
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Gemma Reguera, Dena Cologgi, Robert Mark Worden, Angelines A. Castro-Forero, Rebecca Steidl
  • Palladium, rhenium and alumina catalysts for the selective hydrogenation of carbonyls, their synthesis, and methods of using the same
    Patent number: 9597667
    Abstract: Catalysts useful for the selective hydrogenation of carbonyl groups, including for the reduction of aldehydes to alcohols, are described. The catalysts incorporate palladium and rhenium on an alumina support. Methods of making the catalysts, and methods of using the catalysts for the selective hydrogenation of furanyl 2-carbaldehydes to 2-furanmethanols, are also presented.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: March 21, 2017
    Assignee: North Carolina State University
    Inventors: H. Henry Lamb, Simon T. Thompson