Abstract: Derivatives of camptothecin are disclosed and are represented by the general formula: ##STR1## wherein when R.sub.2 is H, R.sub.1 is a C.sub.2 -C.sub.4 alkyl group, a C.sub.6 -C.sub.15 alkl group, a C.sub.3 -C.sub.8 cycloalkyl group, a C.sub.2 -C.sub.15 alkenyl group or a C.sub.2 -C.sub.15 epoxy group; and when R.sub.2 is a nitro group, R.sub.1 is a C.sub.1 -C.sub.15 alkyl group, a C.sub.2 -C.sub.15 alkenyl group, a C.sub.3 -C.sub.8 cycloalkyl group, or an epoxy group. Processes for mailing these derivatives and for using them in cancer treatment are also disclosed.
Type:
Grant
Filed:
February 25, 1998
Date of Patent:
October 19, 1999
Assignee:
The Stehlin Foundation for Cancer Research
Abstract: A method is disclosed for the preparation of 9-nitrocamptothecin which involves reacting 20-camptothecin with at least one inorganic nitrate salt and at least one acid effective in catalyzing the formation of a nitronium ion, where the reaction occurs at a temperature and for a time sufficient to form the 9-nitrocamptothecin. Also, methods of further purifying the 9-nitrocamptothecin by column chromatography or by reprecipatation is also disclosed.
Type:
Grant
Filed:
August 5, 1997
Date of Patent:
July 13, 1999
Assignee:
The Stehlin Foundation for Cancer Research
Abstract: A method of treating specific forms of cancer with water-insoluble 20(S)-camptothecin compounds with the closed-lactone ring intact and/or derivatives thereof is disclosed. The method includes administering the compounds intramuscularly, orally and transdermally.
Type:
Grant
Filed:
December 17, 1996
Date of Patent:
March 30, 1999
Assignee:
The Stehlin Foundation for Cancer Research
Inventors:
Beppino C. Giovanella, Hellmuth R. Hinz, Anthony J. Kozielski
Abstract: Derivatives of camptothecin are disclosed and are represented by the general formula: ##STR1## wherein when R.sub.2 is H, R.sub.1 is a C.sub.2 -C.sub.15 alkyl group, a C.sub.2 -C.sub.15 alkenyl group or an epoxy group; and when R.sub.2 is a nitro group, R.sub.1 is a C.sub.1 -C.sub.15 alkyl group, a C.sub.1 -C.sub.15 alkenyl group or an epoxy group. Processes for making these derivatives and for using them in cancer treatment are also disclosed.
Type:
Grant
Filed:
January 30, 1996
Date of Patent:
March 24, 1998
Assignee:
The Stehlin Foundation for Cancer Research
Abstract: A method of treating specific forms of cancer with water-insoluble 20(S)-camptothecin compounds with the closed-lactone ring intact and/or derivatives thereof is disclosed. The method includes administering the compounds intramuscularly, orally and transdermally.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
July 29, 1997
Assignee:
The Stehlin Foundation for Cancer Research
Inventors:
Beppino C. Giovanella, Hellmuth R. Hinz, Anthony J. Kozielski, John S. Stehlin
Abstract: A method of treating specific forms of cancer with water-insoluble 20(S)-camptothecin compounds with the closed-lactone ring intact and/or derivatives thereof is disclosed. The method includes administering the compounds intramuscularly, orally and transdermally.
Type:
Grant
Filed:
September 7, 1994
Date of Patent:
September 3, 1996
Assignee:
The Stehlin Foundation for Cancer Research
Inventors:
Beppino C. Giovanella, Hellmuth R. Hinz, Anthony J. Kozielski, John S. Stehlin
Abstract: Methods for purifying camptothecin compounds are described. The camptothecin compounds in purified form are useful in the treatment of cancer.
Type:
Grant
Filed:
February 25, 1993
Date of Patent:
October 4, 1994
Assignee:
The Stehlin Foundation for Cancer Research