Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
Type:
Grant
Filed:
June 2, 2022
Date of Patent:
April 23, 2024
Assignees:
The University of Chicago, J. Craig Venter Institute, Inc., The University of Sheffield, Institute for Systems Biology, The University of Leeds, The University of Strathclyde, The Government of the United States
Inventors:
Rima McLeod, Martin McPhillie, Colin W. G. Fishwick, Hernan Alejandro Lorenzi, Kai Wang, Taek-Kyun Kim, Yong Zhou, Leroy E. Hood, Ying Zhou, Kamal El Bissati, Mark Hickman, QiGui Li, Craig Roberts
Abstract: In a plurality of data analysis apparatuses communicatively coupled to one another, a database is accessed at a given access level. Based on the data acquired from the database, an application program is executed to perform data analysis. Communication control is performed to allow transmission and reception of a data analysis result with respect to another data analysis apparatus at a different access level.
Type:
Grant
Filed:
November 7, 2013
Date of Patent:
June 20, 2017
Assignees:
Okinawa Institute of Science and Technology Graduate University, SBX Corporation, The Systems Biology Institute
Abstract: In a plurality of data analysis apparatuses communicatively coupled to one another, a database is accessed at a given access level. Based on the data acquired from the database, an application program is executed to perform data analysis. Communication control is performed to allow transmission and reception of a data analysis result with respect to another data analysis apparatus at a different access level.
Type:
Application
Filed:
November 7, 2013
Publication date:
October 1, 2015
Applicants:
Okinawa Institute of Science and Technology Graduate University, SBX Corporation, The Systems Biology Institute
Abstract: The present invention involves retrieving edges that do not constitute a designated network model which is a network model designated by a user and are linked to nodes that constitute the designated network model, displaying retrieval results that include the retrieved edges and network model IDs corresponding to the edges in a selectable manner, and generating an integrated network model in which, when the retrieval results are selected by the user, the edges that are included in the selected retrieval results and the nodes that do not constitute the designated network model and are linked to the edges, are integrated into the designated network model.
Type:
Grant
Filed:
March 31, 2011
Date of Patent:
September 15, 2015
Assignees:
OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY, The Systems Biology Institute
Abstract: The present invention acquires compound structure data and candidate protein structure data on a candidate protein serving as a candidate for interaction with the compound. The present invention calculates a binding strength between the candidate protein and the compound using a docking simulation method, determines a predicted binding strength corresponding to the binding strength predicted by making a comprehensive evaluation of the binding strength, and determines a predicted protein corresponding to the candidate protein predicted to interact with the compound. The present invention calculates an interaction strength using a binding strength simulation method and determines a predicted interaction strength corresponding to the interaction strength predicted by making the comprehensive evaluation of the interaction strength.
Type:
Application
Filed:
June 13, 2013
Publication date:
June 18, 2015
Applicants:
Okinawa Institute of Science and Technology Graduate University, The Systems Biology Institute
Abstract: A simulation system includes an interface component connected to a public or shared network that has less restrictive access than networks inside the firewall, generating a simulation job and registering the simulation job in a database, a job control component accessing said database to retrieve the simulation job and scheduling the simulation job for execution, and a simulation execution component receiving the simulation job from the job control component, creating executable codes for numerical and parallel computing algorithms and distributing computing processes to multiple computers to execute the simulation job.
Type:
Application
Filed:
July 11, 2013
Publication date:
March 26, 2015
Applicants:
OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION, THE SYSTEMS BIOLOGY INSTITUTE
Abstract: The present invention involves retrieving edges that do not constitute a designated network model which is a network model designated by a user and are linked to nodes that constitute the designated network model, displaying retrieval results that include the retrieved edges and network model IDs corresponding to the edges in a selectable manner, and generating an integrated network model in which, when the retrieval results are selected by the user, the edges that are included in the selected retrieval results and the nodes that do not constitute the designated network model and are linked to the edges, are integrated into the designated network model.
Type:
Application
Filed:
March 31, 2011
Publication date:
July 18, 2013
Applicants:
The Systems Biology Institute, OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY
Abstract: The present invention sets, for each cells or each condition, a production output of the cells or the biomass based on the measured data and a variable indicating an extent of variation of the production output, calculates a variable range of the production output and the variable in case of combining the multiple cells or conditions based on the production output and the variable set, and calculates an optimum combination within the variable range by using an optimization method.
Type:
Application
Filed:
March 31, 2011
Publication date:
March 28, 2013
Applicants:
The Systems Biology Institute, Okinawa Institute of Science and Technology Graduate University