Abstract: The present invention provides a polymer, preferably a degradable polymer, derived from monomers (A) and (B) and/or comprising a repeat unit of formula (Ii) and at least one terminal group of formula (II).

Abstract: Disclosed herein are antisense oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA at the 5?-end of UBE3A-AS, which is downstream of SNORD115-45 snoRNA. Also disclosed are pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: A method of removing pollutants from flue gas includes cooling the flue gas to remove condensed water. The flue gas is then compressed and dehydrated. The dehydrated flue gas is chilled to separate pollutants.

Abstract: An autonomous landing system includes a vertical landing aircraft, a visual cue coupled to an offshore landing platform and including a visual indicator located that extends vertically across a horizon and is maintained parallel with the horizon, and an autonomous control system configured to control a position of the aircraft with respect to the visual indicator to maneuver the aircraft into a hovering, predefined landing position above the offshore landing platform, and control the position of the aircraft with respect to the visual indicator to cause the aircraft to descend from the landing position and land on the offshore landing platform.

Abstract: In an embodiment, the present disclosure pertains to a method of treating or preventing C. difficile infections. In some embodiments, the method includes administering an antitoxin to a subject in need thereof. In some embodiments, the antitoxin includes a designed ankyrin repeat protein (DARPin). In an additional embodiments, the present disclosure pertains to a composition including an antitoxin for treating or preventing C. difficile infections. In some embodiments, the anti-toxin includes a DARPin. In some embodiments, the anti-toxin is a monomeric or dimeric DARPin for the neutralization of Clostridium difficile toxin B (TcdB).

Abstract: A method for predictive fire control, comprising identifying a plurality of wildfire risk points on a power grid, calculating a route for an unmanned aerial vehicle (UAV) to intersect with a maximum number of points as a function of a range of the UAV, controlling the UAV to traverse the route, monitoring one or more sensors for an indication of a wildfire event and controlling the UAV to release a fire retardant on the fire.

Abstract: In an embodiment, the present disclosure pertains to a supercapacitor composed of a cathode material, a gel electrolyte, and a zinc foil anode. In some embodiments, the cathode material, the gel electrolyte, and the zinc foil anode are in a multilayered configuration. In some embodiments, the cathode and anode materials provide load-bearing capability. In an additional embodiment, the present disclosure pertains to a method of making a supercapacitor. In general, the method includes fabricating a cathode material, preparing a gel electrolyte, coating a zinc foil electrode with the gel electrolyte, and sandwiching the zinc foil electrode with the cathode material. In some embodiments, the sandwiching forms a multilayered configuration composed of the cathode material, the gel electrolyte, and the zinc foil anode.

Abstract: A photonic biosensor including a biological probe disposed on a mid-infrared-transparent waveguide can be used to detect biological analytes in biological samples, using specific binding of the analyte to the probe in conjunction with absorption spectroscopy. In various embodiments, the biosensor is used for molecular diagnostics, e.g., to detect oligonucleotides or proteins associated with a coronavirus.

Abstract: The present disclosure provides intrabody compositions comprising i) an intrabody and ii) one or more inserts. The disclosure also provides methods for activating and deactivating intracellular and extracellular interactions utilizing the compositions, for instance via chemical and/or light.

Abstract: Chalcogenide waveguides with high width-to-height aspect ratios and a smooth exposed surfaces can serve as mid-infrared evanescent-absorption-based sensors for detecting and identifying volatile organic compounds and/or determining their concentration, optionally in real-time. The waveguide sensors may be manufactured using a modified sputtering process in which the sputtering target and waveguide substrate are titled and/or laterally offset relative to each other and the substrate is continuously rotated.

Abstract: Architectures of millimeter-wave (mm-wave) fully-integrated frequency-division duplex (FDD) transmitting-receiving (T/R) front-end (FE) modules include a duplexer (DUX), power amplifier (PA), and low noise amplifier (LNA) on a single semiconductor substrate to facilitate the development of system on a chip (SoC) for mm-wave 5th Generation (5G) wireless communications applications. The first FE module adopts a passive DUX consisting of Wilkinson power divider and ground-center-tap transformer to achieve high isolation between PA output and LNA inputs. Another FE module combines the advantages of passive DUX and power-efficient cancellation circuits to accomplish high TX-RX isolation and low noise performance at the same time. The DUX can stand alone as a single unit in a system and is used together with external PA and LNA provided in the system, or it can include its own internal PA and LNA to form a DUX FE module.

Abstract: A method of characterizing brain activity includes receiving an electroencephalogram (EEG) output. In addition, the method includes determining a mathematical model of a brain using the EEG output, wherein the mathematical model comprises a plurality of ordinary differential equations (ODEs) that are determined based on the EEG output. Further, the method includes characterizing brain activity of a subject using the mathematical model.

Abstract: A method of fabrication processing a pre-preg material includes applying electromagnetic heating to a composition including a fiber and a resin. The electromagnetic heating is conducted with at least one fringing field capacitor utilizing radio frequency (RF) alternating current (AC) and controlling cross-linking of the resin in the composition via the electromagnetic heating.

Abstract: A method and system for decoding low density parity check (LDPC) codes. An LDPC code decoder includes LDPC decoding circuitry comprising a Q message generator and a P sum adder array. The Q message generator combines an R message from a previous iteration with a P message to produce a Q message. The P sum adder array adds the P message to a difference of an R message from a current iteration and the R message from the previous iteration to produce an updated P message.

Abstract: A process for continuously upgrading heavy oil to produce light hydrocarbon gases which are recycled in the process as a carrier gas used in spark-discharge hydrocarbon cracking within the process. The process also produces light hydrocarbon liquids which are used to upgrade the heavy oil. An apparatus for continuously upgrading heavy oil to produce light hydrocarbon gases which are recycled in the as a carrier gas used in spark-discharge hydrocarbon cracking within the apparatus. The apparatus also produces light hydrocarbon liquids which are used to upgrade the heavy oil.

Abstract: Provided herein are stably-modified cell lines such as HEK293 cell lines. The cell lines are modified with an insertion, such as, a transposon containing an inducible recombinase and a promoter and one of a DNA cassette encoding an excisable mitogen, a DNA cassette encoding an inducible gene of interest or a DNA cassette encoding the excisable mitogen and the inducible gene of interest. The stably-modified cell lines are used in methods for producing a biological medical product, for example, in a scalable process for producing biopharmaceuticals.

Abstract: In an embodiment, the present disclosure pertains to a method of performing circulating tumor cell (CTC) analysis. In general, the method includes flowing a sample through a CTC microfluidic platform, deforming a CTC within the sample, measuring CTC deformation through an imprint of the deformed CTC, processing data related to the measuring, and at least one of identifying or characterizing parameters related to the data that enables at least one of detection of CTCs, enumeration of CTCs in the sample, characterization of biophysical properties, CTC cell size, CTC cell membrane deformability, stresses on CTC cell membranes, adhesion stress on CTC cells, normal stress of CTC cells, or combinations thereof. In some embodiments, the flowing includes passing the sample through at least one channel of the CTC microfluidic platform having a constricted section.

Abstract: A 3D strobo-stereoscopic imaging system includes a rotary drive configured to couple to a sample to be imaged by the system, wherein the rotary drive is configured to rotate the sample about a rotational axis when coupled to the rotary drive, a stroboscopic illuminator, a stroboscopic control module coupled to the rotary drive and the stroboscopic illuminator, wherein the stroboscopic control module is configured to repeatedly activate the stroboscopic illuminator at a frequency that is based on a rotational speed of the sample about the rotational axis, a stereoscopic imaging unit including a pair of laterally spaced cameras orientable in the direction of the sample, and an image reconstruction module coupled to the stereoscopic imaging unit and configured to reconstruct a 3D image of the sample from images produced by the pair of cameras of the stereoscopic imaging unit.

Abstract: A system for customer notification system based on outage state of risk prediction, comprising a correlator system operating on a processor and configured to receive uncorrelated outage data, weather data and graph data and to generate geographically and temporally correlated outage data, weather data and graph data. A machine learning system operating on a processor and configured to receive geographically and temporally correlated outage data, weather data and graph data and forecast data and to generate prediction data. A state of risk system operating on a processor and configured to receive the prediction data and to generate state of risk data. A customer notification system operating on a processor and configured to receive the state of risk data and to generate customer notifications as a function of the state of risk.

Abstract: Disclosed are RNA inhibitors, such as small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) specific for RND3, alternatively referred to as RhoE. Also disclosed are methods of treating subjects by administering RNA inhibitors. Further disclosed are methods of detecting potential modulators of RND3.