Patents Assigned to The Thomas Jefferson University
  • Process and medium for cloning and long-term serial cultivation of human endothelial cells
    Patent number: 4994387
    Abstract: Vigorous growth of endothelial cells from human umbilical vein endothelial cells in vitro is achieved using a culture medium containing endothelial cell growth factor and heparin and/or dextran sulfate. Cell population doubling times of 13 to 21 hours for 60 to 85 populations doublings are obtained, and cloned human endothelial cell strains are established having similar proliferative capacities.
    Type: Grant
    Filed: June 17, 1988
    Date of Patent: February 19, 1991
    Assignees: The Wistar Institute, The Thomas Jefferson University
    Inventors: Elliot M. Levine, Sandor S. Shapiro, Bruce E. Jarrell