Patents Assigned to The Trustee of Columbia University in the city of New York
  • Systems and methods for fabricating water-responsive actuators
    Patent number: 11603827
    Abstract: Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: March 14, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Ozgur Sahin, Onur Cakmak, Xi Chen
  • Combination therapy of lymphoma
    Patent number: 11597933
    Abstract: The present disclosure provides for methods and compositions for treating cancer. A subject having lymphoma is administered an EZH2 inhibitor and an HDAC inhibitor. The combination of the EZH2 inhibitor and the HDAC inhibitor produces a synergistic effect on the cancer compared to the effect of the EZH2 inhibitor or the HDAC inhibitor alone.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: March 7, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jennifer Effie Amengual, Jennifer Lue, Owen A. O'Connor
  • Detecting return-oriented programming payloads by evaluating data for a gadget address space address and determining whether operations associated with instructions beginning at the address indicate a return-oriented programming payload
    Patent number: 11599628
    Abstract: Systems, methods, and media for detecting the presence of return-oriented programming (ROP) payloads are provided, comprising: identifying a potential gadget address space; determining if a piece of the data corresponds to an address of the potential gadget address space; and in response to determining that the piece of the data corresponds to an address of the potential gadget address space: determining whether a plurality of operations, each associated one of a plurality instructions beginning at the address, indicates that an ROP payload is present in the data, and indicating that an ROP payload is present in the data in response to making a determination that a plurality of operations indicates that an ROP payload is present in the data a given number of times.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: March 7, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Michalis Polychronakis, Angelos D. Keromytis
  • Apparatus, method, and system for selectively effecting and/or killing bacteria
    Patent number: 11590359
    Abstract: Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: February 28, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow
  • SYSTEMS AND METHODS FOR FABRICATING WATER-RESPONSIVE ACTUATORS
    Publication number: 20230058338
    Abstract: Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position.
    Type: Application
    Filed: May 10, 2019
    Publication date: February 23, 2023
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Ozgur Sahin, Onur Cakmak, Xi Chen
  • Tilapia virus and uses thereof
    Patent number: 11583579
    Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: February 21, 2023
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, RAMOT AT TEL-AVIV UNIVERSITY LTD., KIMRON VETERINARY INSTITUTE
    Inventors: W. Ian Lipkin, Thomas Briese, Nischay Mishra, Eran Bacharach, Avi Eldar
  • Systems and methods for modulation and mapping of brain tissue using an ultrasound assembly
    Patent number: 11577096
    Abstract: Methods and systems for modulation and mapping of brain tissue in a subject using an ultrasound assembly are provided. An exemplary method for modulation uses an ultrasound assembly including a housing and an ultrasound transducer joined to the housing. The method includes securing the housing to the head of the subject with the ultrasound transducer aligned with a region of the brain tissue to target the region of the brain tissue for modulating, and providing focused ultrasound at an acoustic pressure to the targeted region using the ultrasound transducer to induce cavitation proximate the targeted region. The method further includes detecting a cavitation signal magnitude from the induced cavitation corresponding to the acoustic pressure and modulating the targeted region.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: February 14, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elisa E. Konofagou, Gesthimani Samiotaki
  • METHODS FOR TREATING HAIR LOSS DISORDERS
    Publication number: 20230043374
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: July 19, 2022
    Publication date: February 9, 2023
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Monitoring Treatment of Peripheral Artery Disease (PAD) Using Diffuse Optical Imaging
    Publication number: 20230031593
    Abstract: A plurality of modules are simultaneously positioned at locations that correspond to different angiosomes. Each of these modules has a front surface shaped and dimensioned for contacting a person's skin, a plurality of different-wavelength light sources aimed in a forward direction, and a plurality of light detectors aimed to detect light arriving from in front of the front surface. Each module is supported by a support structure (e.g., a strap or a clip) that is shaped and dimensioned to hold the front surface adjacent to the person's skin at a respective position. Perfusion in each of the angiosomes is monitored using these modules, and the surgeon can rely on this information to guide his or her intervention.
    Type: Application
    Filed: August 5, 2022
    Publication date: February 2, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. HIELSCHER, Christopher J. FONG, Jennifer HOI, Hyun K. KIM, Michael KHALIL
  • METHODS OF PREVENTING CANCER METASTASIS
    Publication number: 20230037014
    Abstract: A method of preventing metastasis of a cancer in a patient in need thereof includes administering to the patient a therapeutically effective amount of ibudilast, or a pharmaceutical salt thereof.
    Type: Application
    Filed: July 25, 2022
    Publication date: February 2, 2023
    Applicants: MediciNova, Inc., The Trustees of Columbia University in the City of New York
    Inventors: Kazuko Matsuda, Grazia Ambrosini, Gary K. Schwartz, Alex J. Rai
  • Catalyst compositions including metal chalcogenides, processes for forming the catalyst compositions, and uses thereof
    Patent number: 11565247
    Abstract: Aspects of the present disclosure generally relate to catalyst compositions including metal chalcogenides, processes for producing such catalyst compositions, processes for enhancing catalytic active sites in such catalyst compositions, and uses of such catalyst compositions in, e.g., processes for producing conversion products. In an aspect, a process for forming a catalyst composition is provided. The process includes introducing an electrolyte material and an amphiphile material to a metal chalcogenide to form the catalyst composition. In another aspect, a catalyst composition is provided. The catalyst composition includes a metal chalcogenide, an electrolyte material, and an amphiphile material. Devices for hydrogen evolution reaction are also provided.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: January 31, 2023
    Assignees: HONDA MOTOR CO., LTD., THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Xufan Li, Avetik Harutyunyan, Xiangye Liu, Baiching Li, James Curtis Hone, Daniel V. Esposito
  • MAP kinase modulators and uses thereof
    Patent number: 11566016
    Abstract: The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38? MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: January 31, 2023
    Assignees: The Trustees of Columbia University in the City of New York, Northwestern University
    Inventors: Ottavio Arancio, Daniel Martin Watterson, Jeffrey Claude Pelletier, Saktimayee Mitra Roy
  • In vivo imaging of matrix metalloproteinases in lung disease
    Patent number: 11565004
    Abstract: The present invention provides a method of imaging a subject's lung which comprises contacting the subject's lung with a matrix metalloproteinase inhibitor labeled with a radioisotope under conditions such that the inhibitor binds to matrix metalloproteinase in the lung, and then imaging the radiolabeled inhibitor bound to matrix metalloproteinase in the subject's lung. The invention also provides Ro 32-3555 labeled with a radioisotope.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: January 31, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jeanine D'Armiento, Lynne Johnson, Monica Goldklang, Yared Tekabe
  • METHOD OF MAKING A PERSONALIZED BONE GRAFT
    Publication number: 20230026247
    Abstract: An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.
    Type: Application
    Filed: August 18, 2022
    Publication date: January 26, 2023
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gordana Vunjak-Novakovic, Warren Grayson, Keith Yeager
  • NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20230028321
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.
    Type: Application
    Filed: March 7, 2022
    Publication date: January 26, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Xin Chen, Xiaoxu Li, Zengmin Li, Min-Kang Hsieh, Minchen Chien, Shundi Shi, Jianyi Ren, Cheng Guo, Shiv Kumar, James Russo, Chuanjuan Tao, Steffen Jockusch, Sergey Kalachikov
  • Stabilization of Retromer for the Treatment of Alzheimer's Disease and Other Neurodegenerative Disorders
    Publication number: 20230021959
    Abstract: The present disclosure relates to methods and compositions for elevating and stabilizing retromer for treating and/or preventing Alzheimer's disease and other neurodegenerative disorders. Additionally, the disclosure relates to adenoviral based therapy for treating Alzheimer's disease (AD), and other neurodegenerative conditions such as Parkinson's Disease (PD), neuronal ceroid lipofuscinosis (NCL), and transmissible spongiform encephalopathies (TSEs or prion disease), multiple system atrophy (MSA), Down's syndrome, and hereditary spastic paraplegia, as well as tauopathies such as progressive supranuclear palsy (PSP), frontotemporal lobar dementia linked to chromosome 17q21-22 and its subtypes (FTLD-17/FTLD-Tau), Lewy Body Disease (LBD), amyotrophic lateral sclerosis (ALS), frontal-temporal degeneration (FTD), ALS-FTD, and chronic traumatic encephalopathy (CTE).
    Type: Application
    Filed: December 7, 2020
    Publication date: January 26, 2023
    Applicants: The Trustees of Columbia University in the City of New York, Cornell University, Meiragtx UK II Limited
    Inventors: Scott A. SMALL, Gregory PETSKO, Rebecca COX, Samuel D. WAKSAL, Alexandria FORBES, Yasir H. QURESHI
  • DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS
    Publication number: 20230028388
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
    Type: Application
    Filed: August 1, 2022
    Publication date: January 26, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Xiaoxu Li, Xin Chen, Zengmin Li, Shiv Kumar, Shundi Shi, Cheng Guo, Jianyi Ren, Min-Kang Hsieh, Minchen Chien, Chuanjuan Tao, Ece Erturk, Sergey Kalachikov, James J. Russo
  • Laser induced collagen crosslinking in tissue
    Patent number: 11559433
    Abstract: The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: January 24, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sinisa Vukelic, Gerard A. Ateshian
  • Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor ATF5
    Patent number: 11555057
    Abstract: The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating dominant-negative ATF5 (“CP-d/n-ATF5”), wherein the CP-d/n-ATF5 is capable of inhibiting ATF5 function and/or activity.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: January 17, 2023
    Assignees: The Trustees of Columbia University in the City of New York, The Regents of the University of California
    Inventors: Lloyd A. Greene, James Angelastro
  • DNA SEQUENCING BY SYNTHESIS USING MODIFIED NUCLEOTIDES AND NANOPORE DETECTION
    Publication number: 20230010731
    Abstract: This disclosure is related to a method of sequencing a single-stranded DNA using deoxynucleotide polyphosphate analogues and translocation of tags from incorporated deoxynucleotide polyphosphate analogues through a nanopore.
    Type: Application
    Filed: May 5, 2022
    Publication date: January 12, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Shiv Kumar, Zengmin Li, Chuanjuan Tao, Minchen Chien, James J. Russo, Sergey Kalachikov, Ken Shepard, Jacob Karl Rosenstein