Patents Assigned to The Trustee of Columbia University in the city of New
York
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Patent number: 11937981Abstract: An ultrasound phased array integrated in flexible CMOS technology is provided. The CMOS IC chip is fabricated through various chip-thinning techniques, resulting in mechanical flexibility, robustness, and minimized mechanical loading for the piezoelectric transducers. The ultrasound phased array CMOS patch can allow for the generation of high intensity focal regions for maximum penetration in regions of interest.Type: GrantFiled: December 27, 2017Date of Patent: March 26, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Kenneth Shepard, Tiago Costa, Kevin Tien, Chen Shi
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Publication number: 20240093183Abstract: The present disclosure relates to the methods and systems for multimodal profiling. The method can include stabilizing a target, performing a tagmentation on the target using an agent, and generating a library using a reverse transcriptase enzyme. The agent can include a Tn5 transposome complex, a Tn5 transposase reagent, or a combination thereof, and the Tn5 transposome complex or the Tn5 transposase reagent can be loaded with an adapter. The reverse transcriptase enzyme can be configured to transcribe DNA from both a DNA template and an RNA template and perform a terminal transferase activity by template switching and an introduction of an adapter sequence into a cDNA and a transposed chromatin of the target.Type: ApplicationFiled: June 22, 2023Publication date: March 21, 2024Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Elena E. Kandror, Abbas Haider Rizvi, Thomas Maniatis
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Publication number: 20240093407Abstract: Systems and methods for generating one or more single crystal monolayers from two-dimensional van der Waals crystals are disclosed herein. Example methods include providing a bulk material including a plurality of van der Waals crystal layers, and exfoliating one or more single crystal monolayers of van der Waals crystal from the bulk material by applying a flexible and flat metal tape to a surface of the bulk material. In certain embodiments, the one or more single crystal monolayers can be assembled into an artificial lattice. The present disclosure also provides techniques for manufacturing flexible and flat metal tape for generating one or more single crystal monolayers from two-dimensional van der Waals crystals. The present disclosure also provides compositions for creating a macroscopic artificial lattice.Type: ApplicationFiled: November 29, 2023Publication date: March 21, 2024Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Fang Liu, Xiaoyang Zhu, James Hone, Sang Hoon Chae
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Publication number: 20240085690Abstract: A structured material is provided that includes a substrate and a porous structured polymer layer disposed thereon. The porous structured polymer layer includes a plurality of voids, and has a high hemispherical reflectance a high a hemispherical thermal emittance. The structured material is thus particularly advantageous for cool-roof coatings, enabling surfaces coated by the material to stay cool, even under strong sunlight. The material can be produced via structuring of polymers in a mixture including a solvent and a non-solvent. Sequential evaporation of the solvent and the non-solvent provide a polymer layer with the plurality of voids.Type: ApplicationFiled: August 8, 2023Publication date: March 14, 2024Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Jyotirmoy MANDAL, Yuan YANG, Nanfang YU
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Publication number: 20240085681Abstract: This application describes Swept, Confocally-Aligned Planar Excitation (SCAPE) microscopy systems that incorporate a gradient index (GRIN) lens to relay images from their distal tip to their proximal tip so that 3D images of deep tissue can be captured, without undue loss of light. A zero working distance feature can be designed into the third objective to ensure that the light that exits the second objective in the SCAPE system is not lost. Alternatively, a tapered fiber bundle may be positioned between the second objective and the third objective in the SCAPE system to ensure that the light that exits the second objective is not lost. As yet another alternative, direct detection at the intermediate image plane without using a third objective can ensure that the light that exits the second objective in the SCAPE system is not lost.Type: ApplicationFiled: November 13, 2023Publication date: March 14, 2024Applicant: The Trustees of Columbia University in the City of New YorkInventors: Elizabeth M.C. HILLMAN, Wenxuan LIANG
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Patent number: 11927593Abstract: The present invention is methods and assays for identifying single proteins from a sample, without the use of affinity reagents. The methods and assays combine endopeptidase-based component of conventional peptide mapping with single molecule labeling and a microreactor array platform. The invention also includes kits for performing the methods and assays.Type: GrantFiled: May 18, 2020Date of Patent: March 12, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventor: Peter A. Sims
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Patent number: 11918828Abstract: Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.Type: GrantFiled: May 17, 2021Date of Patent: March 5, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow
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Patent number: 11919913Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R4 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 13, 2021Date of Patent: March 5, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Nicoleta Dobri, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
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Patent number: 11920138Abstract: The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.Type: GrantFiled: July 10, 2019Date of Patent: March 5, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Antonio Iavarone, Anna Lasorella, Raul Rabadan
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Patent number: 11918192Abstract: A medical apparatus having an elongate tubular body with a proximal end, an opening at the proximal end, and a distal end defining an interior space therebetween and the distalmost end of the elongate tubular body is configured to matingly engage a filter assembly; a filter assembly configured to matingly engage the distal portion of the elongate tubular body and to provide a seal with the interior space thereof, the filter assembly comprising a filter membrane and a border that is sectionable for mounting on a slide for analysis on a microscope; and a base member configured to releasably engage the distalmost end of the elongate tubular body and to receive the filter assembly therein.Type: GrantFiled: June 27, 2022Date of Patent: March 5, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Anjali Saqi, Keith Yeager
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Patent number: 11918702Abstract: Described herein are new methods for making lung bud organoids (LBOs) that have the capacity of developing into branching airways and alveolar structures that a least partially recapitulate human lung development from mammalian, preferably human, pluripotent stem cells including embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSC), either by culturing branched LBO in a 3D matrix or by transplanting the LBO under the kidney capsule of immune deficient mice. Branched LBOs contain pulmonary endoderm and mesoderm compatible with pulmonary mesenchyme, and undergo branching morphogenesis. Also described are LBOs harboring certain mutations that induce a fibrotic phenotype, and methods of making same. The mutated (B)LBOs can be used for screening agents that may treat pulmonary fibrosis.Type: GrantFiled: March 26, 2018Date of Patent: March 5, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Hans-Willem Snoeck, Ya-Wen Chen
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Patent number: 11912147Abstract: A system may mitigate leakage currents in non-isolated charging stations for electric vehicles. The system may include a bank of one or more parallel capacitors per phase electrically coupled to an AC voltage source, wherein a neutral point of the one or more parallel capacitors is electrically coupled to a DC ground; a bank of one or more inductors per phase electrically coupled to the one or more parallel capacitors, wherein each inductor is in series with and downstream from one capacitor; a rectifier electrically coupled to and downstream from the one or more parallel inductors, wherein the rectifier converts the AC voltage source to a DC voltage for supply to a battery; a DC bus electrically coupled to the rectifier; and a controller, wherein the controller is configured to mitigate leakage currents by controlling a voltage of at least one of the bank of one or more parallel capacitors.Type: GrantFiled: February 11, 2021Date of Patent: February 27, 2024Assignees: The Trustees of Columbia University in the City of New York, Longmax Corporation LTD.Inventors: William-Michael Eull, Liwei Zhou, Weizhong Wang, Gangqi Cen, Matthias Preindl
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Patent number: 11912707Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.Type: GrantFiled: March 2, 2021Date of Patent: February 27, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Andrew Kruegel, Dalibor Sames, Madalee G. Wulf, Jonathan A. Javitch
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Publication number: 20240060199Abstract: A copper concentrate such as chalcopyrite is contacted with an aqueous solution includes acids and a reducing agent, such as vanadium (II) ions, chromium (II) ions, or tungstozincic acid (H6ZnW12O40). The aqueous solution reduces the copper in the copper concentrate, which can then dissolve into the solution for recovery therefrom, or precipitate out of solution as copper compounds or elemental copper for recovery in as a solid phase product. The solid phase product can then be isolated, dissolved, and further electrowinned to recover a copper product from the copper concentrate. Oxidized reducing agent can be recovered in an electrochemical device with ferrous iron reactants. Hydrometallurgical routes to convert copper concentrates to copper are potentially less expensive and less polluting than current pyrometallurgical processing and an advantageous response to environmental and economic pressures for increased copper production.Type: ApplicationFiled: December 29, 2021Publication date: February 22, 2024Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Jonathan VARDNER, Alan WEST, Scott BANTA
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Publication number: 20240058199Abstract: Rehabilitation or ambulation assistance can be provided to a user by sensing at least one first pressure beneath the user's right foot, sensing at least one second pressure beneath the user's left foot, and predicting the user's gait based on the sensed at least one first pressure and the sensed at least one second pressure. A plurality of motors are energized at a plurality of times that are synchronized with phases of the user's gait so that the plurality of motors pull on respective cables at respective times in a coordinated sequence. Each of the cables has a first end affixed to a pelvic belt or harness that is shaped and dimensioned to fit securely on the user's pelvis, and the timing of the energizing is based on the gait predictions.Type: ApplicationFiled: August 16, 2023Publication date: February 22, 2024Applicant: The Trustees of Columbia University in the City of New YorkInventors: Sunil K. AGRAWAL, Danielle STRAMEL, Jesus Antonio PRADO DE LA MORA
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Patent number: 11906698Abstract: Techniques for creating a replacement for optical elements with diffractive planar components based on metasurfaces are provided. In one example, a substantially flat optical component for lensing incoming electromagnetic radiation having at least one wavelength and a first phase into outgoing electromagnetic radiation having a second phase is provided.Type: GrantFiled: November 22, 2019Date of Patent: February 20, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Nanfang Yu, Adam Overvig, Sajan Shrestha
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Patent number: 11898168Abstract: The current invention provides for methods of promoting differentiation of human pluripotent stem cells into esophageal progenitor cells as well as the cells obtained from the methods, solutions, compositions, and pharmaceutical compositions comprising such cells. The current invention also provides for methods of using the esophageal progenitor cells for treatment and prevention of disease, and kits.Type: GrantFiled: October 10, 2018Date of Patent: February 13, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jianwen Que, Yongchun Zhang
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Patent number: 11899014Abstract: The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.Type: GrantFiled: June 19, 2020Date of Patent: February 13, 2024Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Virginia Wood Cornish, Nili Ostrov, Miguel Jimenez, Sonja Billerbeck
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Patent number: 11896407Abstract: Techniques measuring post contrast phase include collecting 3D medical imagery of a subject after injection with a contrast agent. A first set of slices is obtained in which each includes a first anatomical feature selected from a portal vein, aorta, inferior vena cava, liver, spleen or renal cortex. A second set of slices is obtained in which each includes a different second anatomical feature. A first image region is obtained from the first set and a different second image region from the second set. A trained convolutional neural network is configured to input the first image region to a first plurality of convolutional hidden layers and the second image region to a second plurality of convolutional hidden layers and output from both to a fully connected hidden layer that outputs a post contrast phase. Output data is presented based on the post contrast phase.Type: GrantFiled: May 21, 2021Date of Patent: February 13, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jingchen Ma, Laurent Dercle, Binsheng Zhao, Lin Lu, Lawrence H. Schwartz
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Publication number: 20240041349Abstract: A quantitative gait training and/or analysis system employs instrumented footwear and an independent processing module. The instrumented footwear may have sensors that permit the extraction of gait kinematics in real time and provide feedback from it. Embodiments employing calibration-based estimation of kinematic gait parameters are described. An artificial neural network identifies gait stance phases in real-time.Type: ApplicationFiled: October 12, 2023Publication date: February 8, 2024Applicant: The Trustees of Columbia University in the City of New YorkInventors: Sunil K. AGRAWAL, Jesus Antonio PRADO DE LA MORA