Abstract: Systems and methods are provided for reducing power in in-memory computing, matrix-vector computations, and neural networks. An apparatus for in-memory computing using charge-domain circuit operation includes transistors configured as memory bit cells, transistors configured to perform in-memory computing using the memory bit cells, capacitors configured to store a result of in-memory computing from the memory bit cells, and switches, wherein, based on a setting of each of the switches, the charges on at least a portion of the plurality of capacitors are shorted together. Shorting together the plurality of capacitors yields a computation result.
Type:
Grant
Filed:
February 18, 2022
Date of Patent:
August 13, 2024
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY
Inventors:
Eric G. Nestler, Naveen Verma, Hossein Valavi
Abstract: According to various embodiments, a system for using magnetic reconnection to accelerate plasma is disclosed. The system includes a pair of electrodes including two concentric rings separated by an electrode gap and held at different electrostatic potential by applying a voltage to generate an inter-electrode electric field. The system further includes a plurality of magnetic coils configured to produce magnetic field lines that connect the pair of electrodes. The system additionally includes a gas injector configured to inject gas into the electrode gap, the injected gas being partially ionized by the inter-electrode electric field to generate a poloidal current that flows along open magnetic field lines across the electrode gap.
Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
Type:
Grant
Filed:
October 1, 2021
Date of Patent:
August 6, 2024
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY
Inventors:
Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
Abstract: Provided herein are novel heterocyclic compounds, for example, compounds of Formula (IV-C). Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
Type:
Grant
Filed:
October 17, 2023
Date of Patent:
August 6, 2024
Assignees:
KayoThera Inc., The Trustees of Princeton University
Inventors:
Mark Esposito, John Proudfoot, Yibin Kang, John Piwinski
Abstract: Disclosed is a miniaturized plasma propulsion device with minimized surface area of the thruster walls exposed to the plasma and, as a result, reduced plasma-surface interactions including a set of segmented electrodes to facilitate the following improvements compared to relevant existing technologies: 1) control of the plasma flow including focusing of the plasma plume 2) increase of the thrust 2) reduction of inefficiencies associated with the electron cross field current, and 3) mitigation of low frequency oscillations. The electrodes affect all these actions when a DC or modulated voltage is applied to one or all of them with the same or different amplitudes, with the same or different frequencies or phases which are all optimized to realize the best performance through changes in the acceleration and/or ionization regions. In addition, the applied voltage to the main electrodes may also be modulated.
Abstract: Disclosed herein is an ultrafast, variable multi-focal technique using a laser (such as a picosecond laser or a femtosecond laser) to generate a pulsed laser beam, and a tunable acoustic gradient of index (TAG) lens ahead of an objective lens to achieve multi-focal laser scribing by shaping the pulsed laser beam pulse-by-pulse into a plurality of focal points along an axial axis of the laser beam at one or more selected positions without mechanically moving any optics or sample repositioning. The location of the focal points can be customized and even varied during processing.
Type:
Application
Filed:
January 24, 2024
Publication date:
July 25, 2024
Applicant:
The Trustees of Princeton University
Inventors:
Craig B. Arnold, Xiaohan Du, Camilo Florian Baron
Abstract: Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches.
Type:
Grant
Filed:
October 14, 2021
Date of Patent:
July 23, 2024
Assignees:
AT&T Intellectual Property I, L.P., The Trustees of Princeton University
Inventors:
Yaron Koral, Simon Tse, Steven A. Monetti, Tzuu-Yi Wang, Jennifer L. Rexford, Xiaoqi Chen, Shir Landau Feibish
Abstract: Systems and methods are described, and one method includes illuminating a target-of-interest (TI) with an RF energy configured to effect, over a time duration extending from a first time to a second time, an increase in a temperature of the TI. At a first detection time within the time duration, a first temperature NQR signal spectrum of the TI is detected, and a corresponding first temperature NQR spectrum data set is generates. At a second detection time, subsequent to the first detection time, a second temperature NQR signal spectrum of the TI is detected and corresponding second temperature NQR spectrum data set is output. Based at least in part on the first temperature NQR spectral dataset and the second temperature NQR spectral dataset, the TI is classified between including the SI and not including the SI.
Abstract: According to various embodiments, a system for using magnetic reconnection to accelerate plasma is disclosed. The system includes a pair of electrodes including two concentric rings separated by an electrode gap and held at different electrostatic potential by applying a voltage to generate an inter-electrode electric field. The system further includes a plurality of magnetic coils configured to produce magnetic field lines that connect the pair of electrodes. The system additionally includes a gas injector configured to inject gas into the electrode gap, the injected gas being partially ionized by the inter-electrode electric field to generate a poloidal current that flows along open magnetic field lines across the electrode gap.
Abstract: Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2? to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.
Abstract: Disclosed is a fast-response sensor system to measure a fluid vector in a plurality of dimensions. This system, known as ‘MAST’ (for MEMS Anemometry Sensing Tower), utilizes microelectromechanical (MEMS) hot-wire devices to produce a solid-state, lightweight, and robust flow sensor system suitable for, e.g., real-time wind estimation onboard a UAV. The MAST uses three through eighteen polygonally-arranged microscale flow sensors to determine the fluid's vector's direction and magnitude.
Type:
Application
Filed:
September 12, 2023
Publication date:
June 20, 2024
Applicant:
The Trustees of Princeton University
Inventors:
Nathaniel Simon, Alexander Piqué, David Snyder, Kyle Ikuma, Anirudha Majumdar, Marcus Hultmark
Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.
Abstract: Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.
Abstract: According to aspects of embodiments described herein, an optical computing device (100) comprises a plurality of input waveguides (101), a photonic meta-surface (103) in contact with the plurality of input waveguides, and a plurality of output waveguides (105) in contact with the transformational meta-surface. The optical computing device may be configured to perform a mathematical operation may be a matrix multiplication. A computer-implemented method (300) of designing an optical computing device includes a plurality of input waveguides, a photonic meta-surface, and a plurality of output waveguides, the method includes exciting each input waveguide one-by-one (303) and measuring the energy at the input region and the output region (305) to determine a contribution of the current input waveguide. The sum of contributions (307) of all input waveguides are compared to a target transformation (315) to determine a loss value used to update a set of design parameters (317).
Type:
Application
Filed:
March 9, 2022
Publication date:
May 30, 2024
Applicants:
Siemens Corporation, THE TRUSTEES OF PRINCETON UNIVERSITY, The Penn State University-College of Earth & Mineral Sciences
Inventors:
Heng Chi, Huijuan Xu, Alejandro Rodriguez, Mohamed El Amine Houyou, Wesley Reinhart, Sean Molesky, Pengning Chao
Abstract: Disclosed is a method for experimentally optimizing information quality and engagement in crowd sourced evaluation systems. It allows estimating efficiencies of different strategies to provide the greatest opportunity for social learning. It can be used for continuous tuning of social feedback. Also disclosed is a system that allows experimentation with crowd sourced evaluations of virtual services. The experimental system supports large scale online recruitment of participants into web-browser 3D virtual world. The virtual world can be designed to approximate several types of real-world, distributed information systems. Social influences can be experimentally introduced into the feedback system in order to empirically optimize its utility.
Type:
Grant
Filed:
March 15, 2022
Date of Patent:
May 28, 2024
Assignees:
THE TRUSTEES OF PRINCETON UNIVERSITY, THE CITY UNIVERSITY OF NEW YORK
Abstract: Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
Type:
Grant
Filed:
September 8, 2021
Date of Patent:
May 14, 2024
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY
Inventors:
David MacMillan, Daniel Novoa, Stefan McCarver
Abstract: Various embodiments comprise systems, methods, architectures, mechanisms, apparatus, and improvements thereof for the processing of text-based content such as from a collection of content items including unstructured and structured text of different formats and types so as to automatically derive therefrom an organized, trend-indicative representation of underlying topics/subtopics within the collection of content items.
Abstract: According to various embodiments, a method for detecting security vulnerabilities in at least one of cyber-physical systems (CPSs) and Internet of Things (IoT) devices is disclosed. The method includes constructing an attack directed acyclic graph (DAG) from a plurality of regular expressions, where each regular expression corresponds to control-data flow for a known CPS/IoT attack. The method further includes performing a linear search on the attack DAG to determine unexploited CPS/IoT attack vectors, where a path in the attack DAG that does not represent a known CPS/IoT attack vector represents an unexploited CPS/IoT attack vector. The method also includes applying a trained machine learning module to the attack DAG to predict new CPS/IoT vulnerability exploits. The method further includes constructing a defense DAG configured to protect against the known CPS/IoT attacks, the unexploited CPS/IoT attacks, and the new CPS/IoT vulnerability exploits.
Type:
Grant
Filed:
February 25, 2020
Date of Patent:
April 30, 2024
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY
Inventors:
Tanujay Saha, Najwa Aaraj, Niraj K. Jha
Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I, I-P, II, II-P, III, or IV. Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases, retinoid pathway activation, and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH) or as a male contraceptive.
Type:
Application
Filed:
October 17, 2023
Publication date:
April 25, 2024
Applicants:
KayoThera Inc., The Trustees of Princeton University
Inventors:
Mark ESPOSITO, John PROUDFOOT, Yibin KANG, John PIWINSKI