Abstract: Disclosed are methods of forming an antimicrobial and/or antiviral metal coating on a substrate comprising surface groups that bond to a metal alkoxide to form a 3-dimensional metal oxide/alkoxide adhesion layer. The methods include A) soaking or spraying a substrate comprising a 3-dimensional metal oxide/alkoxide layer with a solution of a transition metal salt, and reduction of the transition metal salt to form a continuous network of transition metal within the 3-D layer, or B) soaking or spraying a substrate comprising a 3-dimensional metal oxide/alkoxide layer with a solution of a post-transition metal salt, sintering at high temperature to form a continuous post-transition metal network within the 3-D layer, and electrolyzing to replace post-transition metal with a transition metal.
Type:
Application
Filed:
September 28, 2021
Publication date:
September 14, 2023
Applicants:
THE TRUSTEES OF PRINCETON UNIVERSITY, ORTHOBOND CORPORATION
Inventors:
Jeffrey Schwartz, Carlos E. Caicedo-Carvajal, Gregorg E. Lutz, Siyang Yang
Abstract: Compositions and methods are provided for DNA barcoding of designer mononucleosome and polynucleosome (chromatin array) libraries for use, for example, for the profiling of chromatin readers, writers, erasers, and modulators thereof.
Type:
Grant
Filed:
August 24, 2018
Date of Patent:
September 12, 2023
Assignee:
The Trustees of Princeton University
Inventors:
Tom W. Muir, Uyen T. T. Nguyen, Manuel M. Mueller
Abstract: Provided herein is an isolated fusion protein comprising a light-responsive domain and a heterologous peptide component. Exposure of the fusion protein to light induces a conformational change in the fusion protein that alters an activity of the fusion protein and the activity is a binding activity selected from an in vitro binding activity, an in vivo extracellular binding activity and an in vivo intracellular binding activity. Also provided are methods of using and identifying the fusion proteins.
Type:
Grant
Filed:
June 1, 2020
Date of Patent:
September 5, 2023
Assignee:
The Trustees of Princeton University
Inventors:
Jared Toettcher, Jose Avalos, Maxwell Wilson, Alexander Goglia, Evan M. Zhao, Agnieszka Gil, Cesar Carrasco-Lopez
Abstract: Systems and methods are described, and one method includes illuminating a target-of-interest (TI) with an RF energy configured to effect, over a time duration extending from a first time to a second time, an increase in a temperature of the TI. At a first detection time within the time duration, a first temperature NQR signal spectrum of the TI is detected, and a corresponding first temperature NQR spectrum data set is generates. At a second detection time, subsequent to the first detection time, a second temperature NQR signal spectrum of the TI is detected and corresponding second temperature NQR spectrum data set is output. Based at least in part on the first temperature NQR spectral dataset and the second temperature NQR spectral dataset, the TI is classified between including the SI and not including the SI.
Abstract: Disclosed herein are solar cells with kesterite-based absorbers that hold promise as a low-cost and durable technology to renewably produce electricity using solar energy conversion. The current state-of-the-art (SOA) for such kesterite solar cells is Cu2ZnSn(S,Se)4 and novel materials are required to suppress the formation bandgap-fluctuation- and charge-carrier-recombination-inducing defects and eventually to achieve solar cell efficiencies higher than the SOA. Three important material properties that govern the efficiency of a solar cell are the concentrations of performance-degrading defects, band gap, and chemical stability. Disclosed here is a stable material, specifically Cu2CdGe(S,Se)4, as a new candidate that can exhibit higher defect formation energies than Cu2ZnSnS4 and a nearly optimal bandgap, which can eventually result in higher solar-cell efficiencies in solar energy conversion.
Type:
Application
Filed:
July 19, 2021
Publication date:
August 24, 2023
Applicant:
The Trustees of Princeton University
Inventors:
Emily A. CARTER, Robert B. WEXLER, Sai Gautam GOPALAKRISHNAN
Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.
Abstract: A method for controlling the encapsulation efficiency and burst release of water soluble molecules from nanoparticle and microparticle formulations produced by the inverted Flash NanoPrecipitation (iFNP) process and subsequent processing steps is presented. The processing steps and materials used can be adjusted to tune the encapsulation efficiency and burst release of the encapsulated water-soluble material. The encapsulation efficiency of the soluble agent in the particles and the burst release of the soluble agent from the particles can be controlled by: (1) the copolymers used in the assembly or coating process, (2) the degree of crosslinking of the nanoparticle core, (3) the incorporation of small molecule or polymeric additives, and/or (4) the processing and release conditions employed.
Type:
Grant
Filed:
July 19, 2019
Date of Patent:
August 22, 2023
Assignee:
The Trustees of Princeton University
Inventors:
Robert K. Prud'homme, Robert F. Pagels, Chester E. Markwalter
Abstract: Various embodiments are directed to Reed-Muller decoding systems and methods based on recursive projections and aggregations of cosets decoding, exploiting the self-similarity of RM codes, and extended with list-decoding procedures and with outer-code concatenations. Various embodiments are configured for decoding RM codes (and variants thereof) over binary input memoryless channels, such as by, for each received word of RM encoded data, projecting the received word onto each of a plurality of cosets of different subspaces to form thereby a respective plurality of projected words; recursively decoding each of the respective plurality of projected words to form a respective plurality of decoded projected words; and aggregating each of the respective decoded projected words to obtain thereby a decoding of the corresponding received word of RM encoded data.
Abstract: Disclosed are dielectric barrier discharge (DBD) devices and methods of use for sterilizing surfaces. The DBD devices generally include one or more first electrodes, one or more second electrodes or chemical reagent layers, and at least one dielectric layer between the one or more first electrodes and the one or more second electrodes or chemical reagent layers. In various configurations, the at least one dielectric layer is either (a) in contact with at least one of the first electrodes or (if present) at least one chemical reagent layer, or (b) is separated from the one or more first electrodes by a first gap and is also separated from the one or more second electrodes or chemical reagent layers by a second gap.
Abstract: Disclosed are systems and techniques for increasing heat transfer from a substrate to a working fluid. The systems may include a substrate comprising a plurality of grooves or cavities on at least one external surface. The system may also include an infusing liquid filling at least a majority of the plurality of grooves. The system may also include a working fluid configured to flow parallel to the external surface.
Type:
Application
Filed:
February 17, 2023
Publication date:
August 17, 2023
Applicants:
The Trustees of Princeton University, Board of Regents, The University of Texas System, KTH Royal Institute of Technology
Inventors:
Marcus Hultmark, Shervin Bagheri, Johan Sundin, Stefano Leonardi, Umberto Ciri
Abstract: Various embodiments comprise systems, methods, architectures, mechanisms or apparatus for providing programmable or pre-programmed in-memory computing operations.
Abstract: When one looks at a face, one cannot help but ‘read’ it: in the blink of an eye, people form reliable impressions of both transient psychological states (e.g., happiness) and stable character traits (e.g., trustworthiness). Such impressions are irresistible, formed with high levels of consensus, and important for social decisions. Disclosed herein is a large-scale data-driven methodology that allows for the easy manipulation of social trait information in hyper-realistic face images. For example, a given face image could be made to look more or less trustworthy by moving a simple slider. Further, this method can not only generate faces, but can ‘read’ faces as well, providing confidence estimates of different social traits for any arbitrary image. The disclosed approach is both fast and accurate, and represents a paradigm shift in facial photo manipulation.
Type:
Grant
Filed:
January 4, 2022
Date of Patent:
August 15, 2023
Assignees:
THE TRUSTEES OF PRINCETON UNIVERSITY, THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY
Inventors:
Alexander T. Todorov, Stefan D. Uddenberg, Joshua C. Peterson, Thomas L. Griffiths, Jordan W. Suchow
Abstract: The present application provides a method of assaying pyruvate dehydrogenase complex (PDHC) activity in a mammalian cell that expresses human sirtuin 4 (SIRT4) comprising measuring a level of a dihydrolipoyllysine acetyltransferase (DLAT) lipoamide peptide comprising the amino acid sequence TDK[lipoyl]AT in the cell. The present application also demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.
Type:
Grant
Filed:
August 12, 2020
Date of Patent:
August 15, 2023
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY
Inventors:
Thomas Shenk, Todd M. Greco, Ileana M. Cristea, Rommel A. Mathias, Adam Oberstein
Abstract: A quantum information processing system comprises a light source, a detector, at least one spatial light modulator and at least one optical lens. The light source is configured to provide a beam of entangled photons. The at least one optical lens is configured to project the resultant beam onto the spatial light modulator, either by direct imaging or by performing a full or partial optical Fourier transform. Said spatial light modulator includes a plurality of discrete pixels and is configured to select one or more of the plurality of discrete pixels to generate a resultant beam from said beam of entangled photons. The resultant beam from said spatial light modulator is projected onto the detector. For optical computation, such as search algorithms, the configuration and projections are repeated to find the optimal solution.
Type:
Grant
Filed:
July 28, 2017
Date of Patent:
August 15, 2023
Assignee:
Trustees of Princeton University
Inventors:
Jason W. Fleischer, Chien-Hung Lu, Xiaohang Sun, Matthew Reichert, Hugo Defienne
Abstract: The present disclosure relates to iron-containing compounds including a 2,6-diimino(heteroaryl) ligand useful for producing substituted-cyclo-alkanes, such as vinyl cyclobutanes. The present disclosure provides new and improved iron-containing catalysts with enhanced solubility in hydrophobic (nonpolar) solvents.
Type:
Application
Filed:
January 19, 2023
Publication date:
August 10, 2023
Applicants:
EXXONMOBIL CHEMICAL PATENTS INC., THE TRUSTEES OF PRINCETON UNIVERSITY
Inventors:
Irene C. Cai, Gursu Culcu, Tzu-Pin Lin, Jo Ann M. Canich, Frank N. Raushel, Alex E. Carpenter, Hua Zhou, Danielle G. Singleton, Paul J. Chirik, Megan Mohadjer Beromi, Carli Kovel
Abstract: The invention described herein relates to colloidal particles useful for photoacoustic imaging. The particles comprise a photoacoustic imaging agent with an absorbance maximum or plateau in the range of wavelengths 700-1100 nm. The imaging agent also displays low optical absorbance at some wavelength in the range 700-1100 nm. This combination of high and low optical absorbance enables background subtraction in photoacoustic imaging applications. The imaging agent is an organic compound having low aqueous solubility so that it is stably encapsulated in the hydrophobic core of the particle. The particle is stabilized by a polymeric surface coating, and the polymeric stabilizing layer on the surface of the particle may contain targeting ligands for targeted diagnostics or therapeutic delivery. The particle core may also contain therapeutic agents or other imaging agents.
Type:
Application
Filed:
April 21, 2023
Publication date:
August 10, 2023
Applicant:
The Trustees of Princeton University
Inventors:
Robert K. Prud'homme, Vikram J. Pansare, Shahram Hejazi, Hoang D. Lu, James Bruce Pitner, Jonathan Lindsey
Abstract: Various embodiments comprise systems, methods, architectures, mechanisms, apparatus, and improvements thereof for in-memory computing using charge-domain circuit operation to provide energy efficient, high speed, capacitor-based in-memory computing. Various embodiments contemplate controlling input signal presentation within in-memory computing structures/macros in accordance with predefined or dynamic switch selection criteria to reduce energy consumption associated with charging and/or discharging summing capacitors during reset and evaluation operating modes of multiplying bit-cells (M-BCs).