Patents Assigned to The Trustee of the University of Pennsylvania
  • Sensitizing cells to proton radiation
    Patent number: 11779644
    Abstract: Materials and methods for enhancing the effectiveness of proton radiation therapy (e.g., high linear energy transfer (LET) proton radiation therapy) against tumor cells are provided herein.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: October 10, 2023
    Assignees: Humanetics Corporation, Trustees of the University of Pennsylvania
    Inventors: Adam J. Harvey, Michael D. Kaytor, Keith Cengel, Eric Stanton Diffenderfer
  • Gene therapy for treating hemophilia A
    Patent number: 11779656
    Abstract: Compositions and regimens useful in treating hemophilia A are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving expression of a human Factor VIII.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: October 10, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Lili Wang, James M. Wilson, Jenny Agnes Sidrane
  • Method for inhibiting dengue virus infection
    Patent number: 11779570
    Abstract: The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.
    Type: Grant
    Filed: June 28, 2022
    Date of Patent: October 10, 2023
    Assignees: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Hengli Tang, Emily M. Lee, Wei Zheng, Ruili Huang, Miao Xu, Wenwei Huang, Khalida Shamim, Guoli Ming, Hongjun Song
  • TROPHIN GENOME EDITING FOR TREATING DUCHENNE MUSCULAR DYSTROPHY (DMD)
    Publication number: 20230313186
    Abstract: The invention relates to compositions and methods for improving a dystrophic phenotype in a human subject having myopathies, such as Duchenne Muscular Dystrophy (DMD). In one embodiment, the invention relates to compositions comprising an adenoviral vector targeting the let-7c miRNA binding sequence in 3?-UTR genome editing of the utrophin gene and methods of treatment comprising administration thereof.
    Type: Application
    Filed: July 26, 2021
    Publication date: October 5, 2023
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Tejvir S. KHURANA
  • Methods and compositions for gene editing in hematopoietic stem cells
    Patent number: 11771719
    Abstract: The present invention relates to compositions and methods of generating modified hematopoietic stem or progenitor cells. One aspect of the invention includes a modified hematopoietic stem or progenitor cell comprising a nucleic acid capable of decreasing expression of an endogenous gene or a portion thereof, wherein the endogenous gene encodes a polypeptide comprising an antigen domain targeted by a chimeric antigen receptor (CAR). Another aspect of the invention includes a method for generating a modified hematopoietic stem or progenitor cell. Also included are methods and pharmaceutical compositions comprising the modified cell for adoptive therapy and treating a condition, such as an autoimmune disease or cancer.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: October 3, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Saar Gill, Miriam Kim
  • Copper alloys for interconnectors and methods for making the same
    Patent number: 11776893
    Abstract: Metallic alloy interconnects (which can comprise copper) with low electrical resistivity and methods for making the same are disclosed. The electrical resistivity of thin film copper alloys was reduced by 36% with niobium solute and by 51% with iron solute compared to pure copper counterpart in dilute solute regimes (0-1.5 atomic %). The fabrication method is operated at room temperature, and does not require a high temperature annealing step.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: October 3, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Daniel S. Gianola, Gyuseok Kim
  • Compositions and methods comprising prostate stem cell antigen (PSCA) chimeric antigen receptors (CARs)
    Patent number: 11766453
    Abstract: The present disclosure provides modified immune cells or precursors thereof (e.g. T cells) comprising a chimeric antigen receptor (CAR) capable of binding human PSCA. CARs capable of binding human PSCA, and nucleic acids encoding the same are also provided. Provided herein are bispecific CARs capable of binding human PSCA and human PSMA, nucleic acids encoding the same, and modified immune cells comprising the same. Modified immune cells comprising a PSMA CAR and a PSCA CAR are also provided. Compositions and methods of treatment are also provided.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: September 26, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Yangbing Zhao
  • Active nematic colloids in microrobotics
    Patent number: 11767473
    Abstract: Provided are compositions that include a nematic colloid, the nematic colloid comprising a nematic liquid crystal and a key colloid; and a lock colloid, the lock colloid optionally having at least two arms extending therefrom, the lock colloid being configured for assembly with the key colloid of the nematic colloid, the assembly optionally being mediated by a dipole interaction between the colloid and the lock colloid, by a disinclination line of the nematic colloid, or any combination thereof. Also provided are related methods. The disclosed compositions and methods can be used to, e.g., assemble chain and lattice structures from the key colloids by exploiting disinclination lines and dipole defects of the components of the compositions.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: September 26, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Tianyi Yao, Kathleen J Stebe
  • Compositions and methods for altering tissue specificity and improving AAV9-mediated gene transfer
    Patent number: 11766448
    Abstract: A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (AAV) viral vector having a capsid containing an AAV9 cell surface binding domain is described. The method involves modifying a clade F cell surface receptor which comprises a glycan having a terminal sialic acid residue and a penultimate ?-galactose residue. The modification may involve retargeting the vector by temporarily functionally ablate AAV9 binding in a subset of cells, thereby redirecting the vector to another subset of cells. Alternatively, the modification may involve increasing cellular update efficiency by treating the cells with a neuraminidase to expose cell surface ?-galactose. Also provided are compositions containing the AAV9 vector and a neuraminidase. Also provided is a method for purifying AAV9 using ?-galactose linked to solid support.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: September 26, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Christie L. Bell, Luc H. Vandenberghe
  • Blood biomarker that predicts persistent cognitive dysfunction after concussion
    Patent number: 11761959
    Abstract: The invention relates to methods for providing prognosis, diagnosis, and treatment of a mild traumatic brain injury (mTBI) in a computed tomography (CT)-negative subject. The invention further relates to monitoring the severity of brain damage resulting from TBI in a subject and determining the prognosis of a subject that has suffered from mTBI. This invention also relates to methods of predicting who is at risk for developing brain damage and long-term dysfunction.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 19, 2023
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Robert Siman
  • Topology optimization for modeling and prediction of complex fabric structures and properties
    Patent number: 11761128
    Abstract: A method for modeling textile structures using bicontinuous surfaces includes selecting a virtual scaffold of bicontinuous surfaces defining textile fabrication pathways to model spatial relationships between the pathways and yarns in a desired yarn pattern of a textile fabric design. The method further includes constructing a yarn pathway across the bicontinuous surfaces that form the virtual scaffold. The method further includes removing or releasing tension from the virtual scaffold, thereby allowing yarns to relax and determining a physical property of the textile fabric design.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: September 19, 2023
    Assignees: Drexel University, The Trustees of the University of Pennsylvania
    Inventors: Genevieve Eugenie Dion, Randall Kamien, Michael David Tanis, Amy Lynne Stoltzfus, Chelsea E. Amanatides, Toen Castle, David Edward Breen, Paras Wadekar
  • Compositions and methods for suppressing or reducing systemic immune response in a subject
    Patent number: 11752159
    Abstract: The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: September 12, 2023
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Taku Kambayashi
  • Non-blood contacting mechanical device that improves heart function after injury
    Patent number: 11752321
    Abstract: A method and device are provided for non-blood contact mechanically assisting an injured (e.g., infarcted) ventricle by coupling an inflatable bladder or other volume adjustable device to the injured ventricle and selectively inflating the bladder or increasing the size of the volume in systole to apply force against the injured ventricle and deflating the bladder or reducing the size of the volume in diastole to remove force against the injured ventricle. When no mechanical assistance is being provided to the injured ventricle, the inflatable bladder or volume adjustable device is preferably maintained at a predetermined pressure so as to selectively stiffen the injured tissue and alter ventricular geometry a desired amount.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: September 12, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James J Pilla, Robert C Gorman, Joseph H Gorman, III
  • Biomarkers predictive of cytokine release syndrome
    Patent number: 11747346
    Abstract: The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: September 5, 2023
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Alfred Garfall, Alex Ganetsky, Saar Gill, Simon Lacey, Jan J. Melenhorst, David Teachey, Eric Lancaster, Adam David Cohen, Pamela Shaw
  • CANINE AND FELINE INDUCIBLE EXPRESSION CONSTRUCTS FOR GENE THERAPY APPLICATIONS
    Publication number: 20230272419
    Abstract: Provided herein are nucleic acid molecules, vectors, and recombinant AAV comprising an inducible gene expression system. The system includes a transgene encoding a gene product operably linked to expression control sequences comprising a promoter; an activation domain comprising a canine or feline transactivation domain and a FKBP12-rapamycin binding (FRB) domain of canine or feline FKBP12-rapamycin-associated protein (FRAP); a DNA binding domain comprising a zinc finger homeodomain (ZFHD) and one, two or three FK506 binding protein domain (FKBP) subunit genes; and at least 8 copies of the binding site for ZFHD (8XZFHD) followed by a minimal IL2 promoter. The presence of an effective amount of a rapamycin or a rapalog induces expression of the transgene in a host cell.
    Type: Application
    Filed: July 26, 2021
    Publication date: August 31, 2023
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Christian Hinderer, Makoto Horiuchi
  • PANEL OF INFLAMMASOME PROTEINS AS RADIATION BIODOSIMETER
    Publication number: 20230273223
    Abstract: The present invention relates to a panel of inflammasone biomarkers for detecting exposure to ionizing radiation and/or for determining absorbed dose of ionizing radiation in a subject exposed thereto.
    Type: Application
    Filed: August 5, 2021
    Publication date: August 31, 2023
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Melpo CHRISTOFIDOU-SOLOMIDOU, Shampa Chatterjee, Thais Sielecki-Dzurd, Ralph Pietrofesa
  • Genetically modified immune cells targeting NY-ESO-1 and methods of use thereof
    Patent number: 11738047
    Abstract: The present disclosure provides modified immune cell (e.g., modified T cell) comprising an exogenous T cell receptor (TCR) having specificity for NY-ESO-1. The present disclosure provides modified immune cells or precursors thereof (e.g., modified T cells) comprising an exogenous TCR and a switch receptor. Gene edited modified cells are also provided, such that the expression of one or more of an endogenous T-cell receptor gene (e.g., TRAC, TRBC) or an endogenous immune checkpoint gene (e.g., PD-1 or TIM-3) is downregulated.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: August 29, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Xiaojun Liu
  • Indomethacin analogs for the treatment of castrate-resistant prostate cancer
    Patent number: 11738004
    Abstract: Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: August 29, 2023
    Assignees: Vanderbilt University, The Trustees of the University of Pennsylvania
    Inventors: Lawrence J. Marnett, Andy J. Liedtke, Trevor M. Penning, Adegoke O. Adeniji, Michael C. Byrns
  • Compositions useful in treatment of ornithine transcarbamylase (OTC) deficiency
    Patent number: 11732246
    Abstract: Viral vectors comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine transcarbamylase deficiency and symptoms associated therewith. Also provided are methods of using hOTC for treatment of liver fibrosis and/or cirrhosis in OTCD patients by administering hOTC.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: August 22, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Lili Wang, James M. Wilson
  • Scalable purification method for AAV9
    Patent number: 11732245
    Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: August 22, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Martin Lock, Mauricio Alvira