Patents Assigned to The Trustees of Columbia University
  • Patent number: 10386097
    Abstract: Systems and methods for radiative cooling and heating are provided. For example, systems for radiative cooling can include a top layer including one or more polymers, where the top layer has high emissivity in at least a portion of the thermal spectrum and an electromagnetic extinction coefficient of approximately zero, absorptivity of approximately zero, and high transmittance in at least a portion of the solar spectrum, and further include a reflective layer including one or more metals, where the reflective layer has high reflectivity in at least a portion of the solar spectrum.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: August 20, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Nanfang Yu, Jyotirmoy Mandal, Adam Overvig, Norman Nan Shi, Meng Tian
  • Patent number: 10388020
    Abstract: Techniques for segmentation of organs and tumors and cells in image data include revising a position of a boundary by evaluating an evolution equation that includes differences of amplitude values for voxels on the boundary from a statistical metric of amplitude of voxels inside, and from a statistical metric of amplitude of voxels outside, for a limited region that lies within a distance r of the boundary. The distance r is small compared to a perimeter of the first boundary. Some techniques include determining a revised position of multiple boundaries by evaluating an evolution equation that includes differences in a first topographical distance from a first marker and a second topographical distance from a second marker for each voxel on the boundary, and also includes at least one other term related to boundary detection.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: August 20, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Xiaotao Guo, Binsheng Zhao, Lawrence H. Schwartz
  • Patent number: 10385150
    Abstract: The present invention provides, inter alia, a process for incorporating a cyclopropenium ion into a polymeric system. Processes for making cross-linked polymers, linear polymers, and dendritic polymers, as well as for incorporating a cyclopropenium ion onto a preformed polymer are also provided. Further provided are stable, polycationic compounds, various polymers that contain stable cyclopropenium cations, and substrates containing such polymers. The use of these polymers in water purification systems, antimicrobial coatings, ion-transport membranes, cell supports, drug delivery vehicles, and gene therapeutic vectors are also provided.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: August 20, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Tristan Hayes Lambert, Luis M. Campos, Jeffrey Bandar, Emma Jane Dell
  • Publication number: 20190250388
    Abstract: In a first invention, a SCAPE system routes light from a tilted intermediate image plane (170) to an infinity space disposed behind a third objective (180). A first dichroic beam splitter (52) positioned in the infinity space routes light from the intermediate image plane with different wavelengths in different directions. First and second light detector arrays (90) capture first and second wavelength images, respectively, and optical components (54,56,58,82) route light having the first and second wavelengths towards the first and second light detectors, respectively. In a second invention, a SCAPE system is used to capture a plurality of images while a sample is perturbed (e.g., vibrated, deformed, pushed, pulled, stretched, or squeezed) in order to visualize the impact of the perturbation on the sample.
    Type: Application
    Filed: September 12, 2017
    Publication date: August 15, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Elizabeth M.C. HILLMAN, Kripa B. PATEL
  • Publication number: 20190246907
    Abstract: The present application discloses methods, devices, and systems for generating spatially-resolved quantification of cross-linking in cartilage based on Raman scattering of excitation light. The examples presented demonstrate that the method provides a discriminating power sufficient to distinguish early onset of osteo-arthritis even before a patient is symptomatic.
    Type: Application
    Filed: June 10, 2017
    Publication date: August 15, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Sinisa VUKELIC, Gerard A. ATESHIAN
  • Publication number: 20190247678
    Abstract: Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one or more ultrasound parameters to a location on the peripheral nerve, and modulating the peripheral nerve. The methods can further include eliciting and measuring a physiological response from the FUS modulation, generating tissue deformation in the vicinity of the FUS modulation, and imaging the nerve and the tissue deformation simultaneously with FUS modulation. Systems for use in the modulation of peripheral nerves are also provided.
    Type: Application
    Filed: February 1, 2019
    Publication date: August 15, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Elisa E. Konofagou, Matthew Downs, Stephen Lee, Min Gon Kim, Hermes Arytto Salles Kamimura
  • Patent number: 10376150
    Abstract: An imaging interface for diffuse optical tomography of breast includes a plurality of concentric rings. Each concentric ring can include a plurality of optical input/output apertures arranged on a radially inner surface thereof. The rings can have different inner and outer diameters from each other and can be arranged in a stacked configuration. The rings can translate independently of each other along a central axis of the stack. During imaging the breast is inserted into an inner region of the stacked rings. The rings can be translated such that the optical input/output apertures are brought into touch contact (i.e., non-compressing contact) with the surface of the breast, so as to accommodate different size breasts. The rings may be translated such that the spacing between adjacent rings is increased for large breasts and reduced for smaller breasts. Rings may be removed or additional rings added to further accommodate additional breast sizes.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: August 13, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. Hielscher, Molly L. Flexman, Keith Yeager
  • Publication number: 20190239751
    Abstract: An optical imaging device and system can be used to visualize and/or provide a quantitative measure of changes in patient vasculature, for example, to monitor responsiveness of a tumor to a particular chemotherapy treatment. A plurality of detectors (e.g., two) are spaced from a plurality of substantially monochromatic light sources (e.g., four) on an interrogation face of the handheld device. Wavelengths of light in the near-infrared range are used to measure the content of hemoglobin, water, and lipid of the tissue that the interrogation face comes in contact with. The light can be modulated so that the effect of ambient light is not minimized or at least reduced. The detected signal is amplified, filtered, and digitized within the device by appropriate electronics. In embodiments, handheld device can include a wireless communication module, such as a Bluetooth device, for wireless transmission of data to/from the remote processor or computer.
    Type: Application
    Filed: September 13, 2018
    Publication date: August 8, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andreas H. HIELSCHER, Molly L. Flexman, Ronny Stoll, Hyun K. Kim
  • Patent number: 10369379
    Abstract: Certain exemplary embodiments of the present disclosure can provide an apparatus and method for generating at least one radiation can be provided. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range can be provided.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: August 6, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow
  • Patent number: 10367797
    Abstract: Methods, systems, and media for automatically authenticating a user account using multiple services are provided. In accordance with some embodiments of the disclosed subject matter, methods for authenticating a user using multiple services are provided, the methods comprising: receiving, from a client device, first credentials for a target service account; authenticating the target service account based on the first credentials; issuing a redirecting request that directs the client device to at least one vouching service in response to authenticating the target service account; receiving a vouching response indicating that the client device has authenticated a vouching service account with the at least one vouching service, wherein the vouching response includes a vouching token; and providing the client device with access to the target service account in response to determining that the vouching service account is associated with the target service account.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: July 30, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Angelos D. Keromytis, Elias Athanasopoulos, Georgios Kontaxis, Georgios Portokalidis
  • Publication number: 20190225925
    Abstract: A perfusion bioreactor chamber for engineering a broad spectrum of tissues. The bioreactor allows controlled distribution of fluid through or around scaffolding materials of various shapes, structures and topologies during prolonged periods of cultivation.
    Type: Application
    Filed: April 2, 2019
    Publication date: July 25, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Gordana Vunjak-Novakovic, Sarindr Bhumiratana, Keith Yeager
  • Publication number: 20190228056
    Abstract: Systems and methods are presented for content extraction from markup language text. The content extraction process may parse markup language text into a hierarchical data model and then apply one or more filters. Output filters may be used to make the process more versatile. The operation of the content extraction process and the one or more filters may be controlled by one or more settings set by a user, or automatically by a classifier. The classifier may automatically enter settings by classifying markup language text and entering settings based on this classification. Automatic classification may be performed by clustering unclassified markup language texts with previously classified markup language texts.
    Type: Application
    Filed: August 24, 2018
    Publication date: July 25, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Suhit Gupta, Gail Kaiser, Salvatore J. Stolfo
  • Patent number: 10358678
    Abstract: Seven protective alleles for IgA nephropathy have been discovered that can be identified by analyzing a DNA sample for seven respective SNPs. A method is provided for identifying and treating subjects at risk of developing IgA neuropathy based on a new seven-SNP genetic risk score. Also provided are screening methods to identify compounds that bind to and reduce the expression or biological activity of a either CFHR1 or CFHR3.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: July 23, 2019
    Assignees: The Trustees of Columbia University in the City of New York, Yale University
    Inventors: Ali Gharavi, Krzysztof Kiryluk, Richard Lifton
  • Patent number: 10358461
    Abstract: The invention is directed to a Ca2+ precipitable polypeptide tags and cassettes useful for purification of molecules from heterogeneous samples. The invention also relates to methods for bioseparation of molecules comprising Ca2+ precipitable tags and cassettes.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: July 23, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Scott Banta, Oren Shur
  • Patent number: 10354377
    Abstract: Techniques for segmentation include determining an edge of voxels in a range associated with a target object. A center voxel is determined. Target size is determined based on the center voxel. In some embodiments, edges near the center are suppressed, markers are determined based on the center, and an initial boundary is determined using a watershed transform. Some embodiments include determining multiple rays originating at the center in 3D, and determining adjacent rays for each. In some embodiments, a 2D field of amplitudes is determined on a first dimension for distance along a ray and a second dimension for successive rays in order. An initial boundary is determined based on a path of minimum cost to connect each ray. In some embodiments, active contouring is performed using a novel term to refine the initial boundary. In some embodiments, boundaries of part-solid target objects are refined using Markov models.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: July 16, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Yongqiang Tan, Binsheng Zhao, Lawrence H. Schwartz
  • Patent number: 10350216
    Abstract: The present invention relates to preventing and treating leukemia and diseases and disorders of the blood, by inhibiting canonical Wnt signaling in the osteoblasts. The inhibition is accomplished by blocking specific molecules and receptors in the pathway. The present invention also relates to a method of diagnosing leukemia and disorders of the blood, and methods and assay for drug screening and basic research.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: July 16, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Stavroula Kousteni
  • Publication number: 20190209570
    Abstract: The present invention provides, inter alia, methods for treating, preventing, or ameliorating the effects of a lymphoid malignancy, such as those associated with a mutated phosphatase and tensin homolog (PTEN) gene, or T-cell acute lymphoblastic leukemia (T-ALL). These methods include administering to a subject an effective amount of a phosphoinositide 3-kinase-delta (PI3K?) inhibitor and a phosphoinositide 3-kinase-gamma (PI3K?) inhibitor. The present invention also provides pharmaceutical compositions for treating the effects of a lymphoid malignancy. This invention further provides a method for identifying a subject who may benefit from co-treatment with a PI3K? inhibitor and a PI3K? inhibitor. This method includes determining from a sample of the subject whether the subject has a mutated PTEN gene. Additionally, this invention provides methods for identifying a compound that has both PI3K? and PI3K? inhibitory activity.
    Type: Application
    Filed: December 6, 2018
    Publication date: July 11, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventor: Thomas DIACOVO
  • Publication number: 20190215328
    Abstract: A system and methods for detecting intrusions in the operation of a computer system comprises a sensor configured to gather information regarding the operation of the computer system, to format the information in a data record t, and to transmit the data. A database is configured to receive the data record from the sensor and to store the data record. A detection model generator is configured to request training data from data record, generate an intrusion detection model based on said training data, and to transmit the intrusion detection model to the data warehouse according to the predetermined data format. A detector is configured to receive a data record from the sensor and to determine whether said data record corresponds to an attack based on said intrusion detection model.
    Type: Application
    Filed: March 19, 2019
    Publication date: July 11, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew Honig, Andrew Howard, Eleazar Eskin, Salvatore J. Stolfo
  • Publication number: 20190210883
    Abstract: Methods and systems for producing highly activated silicate materials are disclosed. A silicate source material is provided for reaction with a reforming agent in a reforming process. The reforming process is a hydrothermal process and/or a high temperature silicate reforming (HTSR) process. The reaction materials are brought to the suitable reaction temperature via a heat source in the presence of the suitable reaction medium. For the hydrothermal reaction process, the reaction medium and heat source can be exhausted steam that is the byproduct of another industrial process. For the HTSR process, the silicate source material and the heat source can be a molten slag byproduct from another industrial process. The activated silicate materials exhibit improved reactivity compared to non-activated silicate materials and thus are advantageously employed in elemental extraction processes to produce a value material product.
    Type: Application
    Filed: September 19, 2017
    Publication date: July 11, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Ah-Hyung Alissa PARK, Xiaozhou ZHOU, Chengchuan ZHOU
  • Publication number: 20190202723
    Abstract: Methods and systems for controlling a denitrification reaction in a biological nitrogen removal reactor including denitrifying bacteria to favor denitratation of nitrate to nitrite and limit denitritation of nitrite to nitrogen gas are disclosed. pH, dissolved oxygen levels, solids retention time, and chemical oxygen demand to nitrogen ratio are controlled to favor this reaction. Wastewater or contaminated groundwater including concentrations of ammonium and nitrate are continuously fed to the biological nitrogen removal reactor along with a source of carbon and electrons as an influent, which is treated to form a nitrite effluent. The nitrite effluent may then be fed to an anammox reactor including anammox bacteria for production of nitrogen gas. The system may be operated under substantially anoxic conditions, which provides significant cost savings without sacrificing efficiency or productivity compared to traditional wastewater treatment systems and processes.
    Type: Application
    Filed: June 22, 2017
    Publication date: July 4, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Kartik CHANDRAN, Luke PLANTE