Abstract: Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.
Type:
Application
Filed:
August 24, 2007
Publication date:
July 24, 2008
Applicant:
The Trustees of Columbia University in the City of New York, Office of the General Counsel
Inventors:
Sally A. Amundson, Daniel Attinger, Chee Wei Wong