Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: System and methods for monitoring cardiac ablation procedures are disclosed. The system can comprise an imaging device and an image processor. The imaging device can be configured to acquire successive frames and radio frequency signal data of a heart. The image process, coupled to the imaging device, can be configured to obtain a signal envelope of the radio frequency signal data, generate a strain map based on the signal envelope, apply a strain threshold to the strain map for classification of lesion tissue, and provide an image which visualizes lesion formation during the cardiac ablation procedures in real-time.

Abstract: The present disclosure provides energy storages devices that include electrodes that comprise an alkali metal. The present disclosure also provides related methods of using and fabricating the disclosed devices.

Abstract: The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.

Abstract: Systems and methods of performing temperature swing solvent extraction (TSSE) descaling of produced water and desalination of high-salinity brines, e.g., those having a total dissolved solids (TDS) greater than about 250,000 ppm are capable of producing descaled water products including less than about 5% weight percent TDS. The brine/produced water feedstreams and combined with a solvent having temperature-dependent water solubility at a temperature TL. Water is extracted from the feedstream into the solvent to form a water-in-solvent extract component and a raffinate component, from which a solid phase can be precipitated as more water is portioned in the solvent and basicity increases. Heating of the water-in-solvent extract component reduces the solubility of the water therein, producing a biphasic mixture of dewatered solvent and descaled water that can be separated.

Abstract: This invention provides nucleoside polyphosphate analogues each of which comprises a tag comprising a plurality of Raman-scattering moieties; compounds comprising said nucleoside polyphosphate analogs. This invention also provides nucleotide polymerases with one or more attached and/or conjugated noble metal nanoparticles, wherein the noble metal nanoparticles are surface-enhanced Raman spectroscopy (SERS) substrates thereby creating a region of enhanced sensitivity for surface enhanced Raman spectroscopy (SERS) within or adjacent to the polymerase. This invention also provides a surface with regions of enhanced sensitivity for surface enhanced Raman spectroscopy comprising interspersed rough or nanostructured noble metal surface. This invention also provides methods for determining the sequence of a single stranded DNA or RNA polynucleotide using one or more of nucleoside polyphosphate analogues, polymerase with noble metal nanoparticles, and surface with noble metal.

Abstract: Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method that includes determining whether an operation to access a memory location containing executable code comprises a general-purpose memory access operation, and changing content of the memory location in response to a determination that the operation to access the memory location containing the executable code comprises the general-purpose memory access operation to the memory location.

Abstract: The present disclosure provides organic compounds having pseudocapacitive performance and methods of preparing said compounds. The organic compounds can include perylene diamine (PDI) subunits and hexaazatrinaphthylene (HATN) subunits.

Abstract: All-temperature flexible supercapacitors are prepared using a hydrogel electrolyte including a poly(vinyl alcohol) (PVA) substrate a montmorillonite (MMT) dopant, along with a 2M sulfuric acid and dimethyl sulfoxide/water aqueous electrolyte dispersed therein. Incorporation of MMT material enhances the thermal stability of PVA polymers, whereas the DMSO/H2O binary system endows the hydrogel with an ultralow freezing point below ?50° C. The hydrogel electrolyte displays good mechanical properties and shows superior electrochemical properties in a wide temperature range. The ionic conductivities are 0.17×10?4 and 0.76×10?4 S cm?1 under operation temperatures of ?50 and 90° C., respectively. The supercapacitor exhibits a high specific capacity of 161 F g?1 with a high rate capability and life over 10,000 cycles.

Abstract: The disclosed subject matter provides systems and methods for identifying bioactivities of biopolymers from sequence data of the biopolymers. The disclosed system can include a processor configured to receive the input data and a storage medium including instructions operable when executed by the processors. The instructions can cause the system to obtain the input data and generate an evaluative model configured to acquire a biophysical model parameter, a model interaction parameter, a count table parameter, or combinations thereof utilizing the input data. The evaluative model can be configured to simultaneously use multiple biophysical models to represent one or more sequence recognition modes of the biopolymers, evaluate the biopolymers using the evaluative model, and generate a value using the evaluating model that corresponds to the bioactivity of each biopolymer.

Abstract: Exemplary computer-accessible medium, systems, and methods are described herein which can provide an excited fluorescence radiation. In accordance with certain exemplary embodiments of the present disclosure, an excited fluorescence radiation can be provided using a beam of a probe so as to excite a molecule to an excited state for a fluorescence emission to effectuate the excited fluorescence radiation. The molecule can be detected based on the fluorescence emission. For example, the beam of the probe can be either the near-infrared spectrum or the visible light spectrum.

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

Abstract: A circulator, comprising: a gyrator having a first side (1S) and a second side (2S) connected to a third port; a first transmission line section (TLS) having a 1 S connected to the 1 S of the gyrator and a 2S connected to a first port; a second TLS having a 1S connected to the first port and having a 2S connected to a second port; a third TLS having a 1S connected to the second port and having a 2S connected to the third port; a first cancellation path (CP) that is connected between the first port and the third port and introduces a current that is 90 degrees out of phase with a first voltage at the first port; and a second CP that is connected between the second port and the third port and introduces a current that is orthogonal to the current introduces by the first CP.

Abstract: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.

Abstract: The disclosed subject matter includes a wearable device for blood pressure monitoring. The embodiments employ a set of sensors to calculate a relative external pressure. A transmural pressure error can be calculated based on the relative external pressure. A measured transmural pressure can be corrected based on the transmural pressure error. Some embodiments track altitude to calculate relative external pressure error. Some embodiments track arm orientation to calculate relative external pressure error.

Abstract: The present invention provides, inter alia, a compound having the structure of Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.

Abstract: The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

Abstract: Methods and compositions for treating frailty in mammals, preferably humans, are provided. The methods generally involve modulation of the OST-PTP signaling pathway or the PTP-1B signaling pathway involving gamma-carboxylase and osteocalcin, e.g., by administration of undercarboxylated/uncarboxylated osteocalcin. The methods comprise alleviating at least one of: muscle wasting or a lung disorder while also alleviating at least one of: a metabolic disorder, a male reproductive disorder, or a cognitive disorder.

Abstract: Methods, systems, and media for testing insider threat detection systems are provided.

Abstract: A method of forming an emitting array of waveguides, comprising providing a plurality of waveguides that exhibit different propagation constants so as to ensure that nearby waveguides do not couple evenly over parallel propagation lengths by varying a length in one or more dimensions of respective waveguides, whereby the respective waveguides are phase mismatched with at least their nearest neighbor.