Patents Assigned to The Trustees Of Columbia Univesity In The City Of New York
  • Potent Non-Urea Inhibitors Of Soluble Epoxide Hydrolase
    Publication number: 20120029022
    Abstract: The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
    Type: Application
    Filed: July 7, 2011
    Publication date: February 2, 2012
    Applicant: The Trustees Of Columbia Univesity In The City Of New York
    Inventors: Donald W. Landry, Yuli Xie, Yidong Liu, Gangli Gong, Shi-Xian Deng, Kirsten Alison Rinderspacher