Patents Assigned to The Trustees of Columbia Unviersity in the City of New York
  • METHODS AND COMPOSITIONS FOR PREDICTING THERAPEUTIC EFFICACY OF KINASE INHIBITORS IN PATIENTS WITH MYELODYSPLASTIC SYNDROME OR RELATED DISORDERS
    Publication number: 20160102363
    Abstract: The invention discloses a diagnostic method for predicting the therapeutic efficacy of a broad specificity kinase inhibitor in a subject with refractory cancer comprising determining the locus-specific DNA methylation profile of the subject, wherein the locus-specific DNA methylation profile predicts the therapeutic efficacy of a broad specificity kinase inhibitor for treatment of a subject with refractory cancer.
    Type: Application
    Filed: May 28, 2014
    Publication date: April 14, 2016
    Applicants: ONCONOVA THERAPEUTICS, INC., THE TRUSTEES OF COLUMBIA UNVIERSITY IN THE CITY OF NEW YORK
    Inventors: BENJAMIN TYCKO, AZRA RAZA, FRANCOIS WILHELM
  • Compounds and methods for inhibiting serotonin synthesis
    Patent number: 8815883
    Abstract: Compounds having the structures below that are TPH1 inhibitors are provided: The compounds are useful of, e.g., to increase bone mass. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: August 26, 2014
    Assignee: The Trustees of Columbia Unviersity in the City of New York
    Inventors: Donald Landry, Shi-Xian Deng