Abstract: We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) a real capacitor, whose value exactly emulates the value of the quantum constant ? termed a Planck capacitor; 2) a ‘quantum admittance’ element, which has no classical equivalent, but which can be emulated by approximately 18 transistors of a coupled transconductor system; 3) an emulated ‘quantum transadmittance element’ that can couple emulated quantum admittances to each other; and 4) an emulated ‘quantum transadmittance mixer element’ that can couple quantum admittances to each other under the control of an input. We describe how these parts may be composed together to emulate arbitrary two-state and discrete-state quantum or quantum-inspired systems including stochastics, state preparation, probability computations, state amplification, state attenuation, control, dynamics, and loss compensation.

Abstract: Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation and allergic disorders is disclosed herein.

Abstract: We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) capacitors that represent ? termed Planck capacitors; 2) a ‘quantum admittance’ element, which can be emulated efficiently via coupled transconductors; 3) an emulated ‘quantum transadmittance element’ that can couple emulated quantum admittances to each other; and 4) an emulated ‘quantum transadmittance mixer element’ that can couple emulated quantum admittances to each other under the control of an input. We describe a ‘Quantum Cochlea’, a biologically-inspired quantum traveling-wave system with coupled emulated quantum two-state systems for efficient spectrum analysis that uses all of these parts.

Abstract: Provided herein are photochromic organic compounds of Formula I or Formula II, which are useful as molecular switches capable of being triggered via a cis/trans isomerization process. Methods of using the molecular switch compounds to form photopharmaceutical compounds that may be used to provide selective spatiotemporal activation of pharmaceutical agents are also disclosed.

Abstract: A system for measuring responses of magnetic nanoparticles has static magnetic bias field along first axis, and AC driving coils providing AC magnetic field along second axis perpendicular to the first axis, both fields passing through an imaging zone. Sensing coils are oriented to sense fields parallel to the first axis, but not parallel to the second axis. A processor determines responses of nanoparticles in the imaging zone to the AC field. Another system has DC bias on first axis and AC driving coils providing an AC magnetic field along a second axes, magnetic gradient oriented along the first and/or second axis, and the second axis is rotated mechanically or electronically. The signal processor provides a voxel-based model of magnetic nanoparticle distribution in imaging zone. In some embodiments, the static magnet is a main magnet of a magnetic resonance imaging system.

Abstract: A method for cardiovascular-dynamics correlated imaging includes receiving a time series of images of at least a portion of a patient, receiving a time series of cardiovascular data for the patient, evaluating correlation between the time series of images and the time series of cardiovascular data, and determining a property of the at least a portion of a patient, based upon the correlation. A system for cardiovascular-dynamics correlated imaging includes a processing device having: a processor, a memory communicatively coupled therewith, and a correlation module including machine-readable instructions stored in the memory that, when executed by the processor, perform the function of correlating a time series of images of at least a portion of a patient with a time series of cardiovascular data of the patient to determine a property of the at least a portion of a patient.

Abstract: We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) capacitors that represent ? termed Planck capacitors; 2) a ‘quantum admittance’ element, which can be emulated efficiently via coupled transconductors; 3) an emulated ‘quantum transadmittance element’ that can couple emulated quantum admittances to each other; and 4) an emulated ‘quantum transadmittance mixer element’ that can couple emulated quantum admittances to each other under the control of an input. We describe a ‘Quantum Cochlea’, a biologically-inspired quantum traveling-wave system with coupled emulated quantum two-state systems for efficient spectrum analysis that uses all of these parts.

Abstract: A system for providing monitored radiation therapy has a high energy radiation source, apparatus for excluding uncontrolled ambient light, and apparatus for collecting light emitted from a subject. The system has apparatus for spectrally analyzing the collected light, and a processor for determining oxygenation or other metabolic function of tissue within the subject from spectral analysis of the collected light. The system monitors radiation therapy by providing a beam of high energy radiation; collecting Cherenkov and/or photoluminescent light from the subject, the light generated along the beam; spectrally analyzing the light; and determining oxygenation or metabolic function of tissue from the spectral analysis. Beam profile of the system is calibrated by imaging from multiple angles Cherenkov and/or photoluminescent light emitted by a phantom placed in the beam in lieu of a subject, captured images are analyzed to determine beam profile.

Abstract: Disclosed herein are new face-centered cubic (f.c.c.) high-entropy alloys with compositions (in atomic %) of FeaNibMncAldCreCf where a is between 37-43 atomic %, b is between 8-14 atomic %, c is between 32-38 atomic %, d is 4.5-10.5 atomic %, e is between 2.5-9 atomic % and f is between 0-2 atomic %. The undoped alloy has strength of 159 MPa and 40% elongation to failure, but the doped, carbon-containing alloy having 1.1 atomic percent carbon has yield strength of 360 MPa, an ultimate tensile strength (UTS) of 1200 MPa and 50% elongation to failure at room temperature. At 700° C., the yield strength is 214 MPa with 24% elongation to failure. Thus, the present alloy may replace austenitic stainless steels in applications where better strength is needed at both room temperature and elevated temperature in an oxidation resistant alloy.

Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided.

Abstract: A method for producing a porous piezoelectric polymer film with a dense surface, includes depositing a polymer solution onto a substrate to form a polymer film including a solvent; evaporating a portion of the solvent to form the dense surface away from the substrate; forming water droplets in interior of the polymer film; and substantially evaporating the water droplets and remaining solvent to form porous interior. A piezoelectric composition includes a piezoelectric material with a porous interior and a dense surface for interfacing with an electrode. A piezoelectric device includes a first electrode; a porous piezoelectric film with a dense surface and porous interior, wherein the porous piezoelectric film is deposited on the first electrode and the dense surface is away from the first electrode; and a second electrode deposited on the dense surface for, together with the first electrode, providing an electrical interface for the porous piezoelectric film.

Abstract: A system for dielectric testing of wine in a bottle includes (a) a coaxial probe for interrogating the wine, wherein the coaxial probe has an open end for contacting an exterior surface of the bottle, and (b) a measurement module for determining a dielectric property associated with the wine by generating and measuring radio waves propagating through the coaxial cable. A method for dielectric testing of wine in a bottle includes measuring a radio-wave reflection signal associated with the wine by interrogating the wine, through the bottle, with radio waves, and determining a dielectric property associated with the wine from the radio-wave reflection signal. A probe for radio-wave interrogation of wine in a bottle has an inner conductor, an outer conductor, and an open end with curvature matching the curvature of an exterior surface of the bottle.

Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.

Abstract: Intergenic non-coding RNA molecules that regulate the expression of HWP1 and ALS3 of Candida are provided as are methods of using the non-coding RNA molecules and complementary molecules thereof in modulating HWP1 or ALS3 expression; adherence, yeast-to-hyphal transition, or biofilm development of Candida; and preventing or treating candidiasis.

Abstract: A multilayer conductor includes at least one separation dielectric layer and a plurality of conductor layers stacked in an alternating manner. Each of the plurality of conductor layers includes a first conductor sublayer and a second conductor sublayer separated from the first conductor sublayer by a sublayer dielectric layer. The second conductor sublayer at least partially overlaps with the first conductor sublayer in each of the plurality of conductor layers. The multilayer conductor is included, for example, in a device including a magnetic core adjacent to at least part of the multilayer conductor.

Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA: Cholesterol Acyltransferase 1, but not Acyl-CoA: Cholesterol Acyltransferase 2.

Abstract: Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of Thermoanaerobacterium saccharolyticum with acetate kinase and phosphotransacetylase expression eliminated are disclosed herein. Further, strain ALK1 has been engineered by site directed homologous recombination to knockout both acetic acid and lactic acid production. Continuous culture involving a substrate concentration challenge lead to evolution of ALK1, and formation of a more robust strain designated ALK2. The organisms may be utilized for example in thermophilic SSF and SSCF reactions performed at temperatures that are optimal for cellulase activity to produce near theoretical ethanol yields without expressing pyruvate decarboxylase.

Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed. In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.

Abstract: A molecularly imprinted polymer sensor for sensing a target molecule includes (a) a polymer film that is molecularly imprinted with the target molecule and includes a conductive polymer having resistance sensitive to binding with the target molecule and a structural polymer providing porosity to the polymer film, and (b) interdigitated electrodes, located on a surface of the polymer film, for measuring a change in the resistance to sense said binding.

Abstract: The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in S. aureus. The compositions also have the ability to inhibit growth of S. aureus and as such are useful as antibiotic compounds.