Abstract: Polynucleotide sequences which encode ecdysone receptors have been isolated and expressed in host cells.

Abstract: The human DNA polymerase .alpha. catalytic polypeptide has been functionally over-expressed by a recombinant baculovirus in insect cells at >1000 fold higher levels than that found in cultured normal human cells.

Abstract: This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase promoter region complement and then anti-sense RNA (aRNA) is transcribed from the cDNA by introducing an RNA polymerase capable of binding to the promoter region. Additional processes using the resulting aRNA are also described.

Abstract: Compositions and methods are provided for the detection and treatment of Schistosoma parasites. These compositions and methods are based on nucleic acid and amino acid sequences of Schistosoma phosphofructokinase.

Abstract: Optical communication apparatus for simultaneously and reconfigurably establishing optical communication channels, comprises at least one light source and a plurality of wavelength-selective detectors optically associated with each light source, the detectors arranged one behind another. The apparatus uses wavelength-division-multiplexing (WDM) to facilitate simultaneous and reconfigurable communication of one-to-many 2-D optical planes. This advance dramatically increases the system functionality of optical-plane interconnects. Such a system is realized by incorporating several multiple wavelength vertical-cavity surface-emitting lasers (VCSEL) into each transmitting pixel and incorporating wavelength selectivity into each subsequent detecting plane which will absorb one wavelength and be transparent to the rest; these structures can be fabricated by slightly modifying existing technology.

Abstract: Polynucleotide sequences which encode ecdysone receptors have been isolated and expressed in host cells.

Abstract: A combined atomic force and near field microscope assembly for atomic level inspection of a target object. The assembly includes a scanning probe with a sharp tip and a photosensitive region on its lower surface. A sample is disposed on a glass substrate and exposed to an evanescent wave generated on the glass substrate by total internal reflection. An optical probe comprising a microfabricated cantilever having an apex in close proximity to a photosensitive region is disposed in close proximity to a sample. The photosensitive region collects light generated by FTR at the apex of the optical probe due to local disruptions of the evanescent field caused by the probe tip. A cantilever displacement mechanism is included so as to allow for operation in a second mode as a conventional atomic force microscope.

Abstract: A long RF pulse is segmented into a plurality of RF pulses segments with nuclei spin refocusing pulses provided after each RF pulse segment to maintain phase coherence off resonance and decrease nuclei spin sensitivity to magnetic field inhomogeneity. The refocusing pulses are preferably 180.degree. rectangular pulses. Magnetic gradient segments associated with the RF pulse segments have supplemental gradients at the beginning and at the end of the gradient segment to ensure that the position in k-space for the segment corresponds to the k-space position of the gradient waveform before division into segments.

Abstract: A Brillouin fiber optic gyroscope has a cavity loop that includes a first length of optical fiber wound as a first number of turns in a first direction to provide a selected system response that includes the dynamic range of gyroscope rotation rate, the resolution of the gyroscope rotation rate measurement, the relative lock-in range and the relative Kerr-effect-induced beat-frequency bias. The cavity loop further includes a second length of optical fiber wound as a second number of turns in the same direction as the first number of turns and wound as a third number of turns in an opposite direction to the winding direction of the first and second number of turns. The effect of the second and third number of turns is to increase the overall length of the optical fiber in the cavity loop to reduce the pump power required to generate Brillouin laser light within the cavity loop without increasing the Sagnac effect within the cavity loop.

Abstract: An insertion device for extracting polarized electromagnetic energy from a beam of particles is disclosed. The insertion device includes four linear arrays of magnets which are aligned with the particle beam. The magnetic field strength to which the particles are subjected is adjusted by altering the relative alignment of the arrays in a direction parallel to that of the particle beam. Both the energy and polarization of the extracted energy may be varied by moving the relevant arrays parallel to the beam direction. The present invention requires a substantially simpler and more economical superstructure than insertion devices in which the magnetic field strength is altered by changing the gap between arrays of magnets.

Abstract: A method for modelling the electron density distribution of a macromolecule in a defined asymmetric unit of a crystal lattice having locations of uniformly diffracting electron density includes the steps of: producing an initial distribution of scattering bodies with a asymmetric unit having the same dimensions as the defined asymmetric unit; calculating scattering amplitudes of the initial distribution and determining the correlation between the calculated scattering amplitudes and the normalized amplitudes; moving at least one of the scattering bodies within the asymmetric unit to create a modified distribution; calculating scattering amplitudes and phases of the modified distribution and determining the correlation between the calculated amplitudes and producing a final distribution of scattering bodies by repeating moving and calculating steps until the correlation between the calculated scattering amplitudes and the normalized amplitudes is effectively maximized, the final distribution of scattering bodi

Abstract: An interferometer used as a rotation sensor is constructed using a strand of optical fiber, a portion of which is formed into a sensing loop. A pair of light waves are caused to counterpropagate in the sensing loop and are combined to form an optical output signal that has an intensity that varies in accordance with the difference in the phases of the two counterpropagating light waves. A phase modulator is positioned on the optical fiber in the sensing loop at a location such that the two counterpropagating light waves are modulated approximately 180 degrees out of phase. The time-varying phase modulation causes a time-varying phase difference that is combined with a rotationally-induced Sagnac effect phase to provide a total phase difference that is detected by a photodetector. The photodetector provides an electrical output signal that is processed to determine the Sagnac phase difference. The rotation rate is then calculated from the Sagnac phase difference.

Abstract: A method for constructing an image of a macromolecular crystal includes steps of providing an envelope which defines the region of a unit cell occupied by the macromolecule; distributing a collection of scattering bodies within the envelope; condensing the collection of scattering bodies to an arrangement that maximizes the correlation between the diffraction pattern of the crystal and a pattern of Fourier amplitudes for the collection of scattering bodies; determining the phase associated with at least one of the Fourier amplitudes of the condensed collection of scattering bodies; calculating an electron density distribution of the crystal from the phase information; and defining an image of the macromolecule in the electron density distribution.

Abstract: A Brillouin fiber optic gyroscope having a feedback system which monitors the difference between counterpropagating Brillouin intensities and utilizes this difference in the form of a correction signal to control one of the circulating pump intensities so as to equalize the circulating pump intensities. The Brillouin fiber optic gyroscope further includes a second feedback system which detects electrical signals proportional to the phase-modulated, counterpropagating intensities in the gyroscope, and utilizes a combination of the electrical signals as an error signal to stabilize the resonant cavity at a length substantially equal to a length midway between the resonant lengths of the counterpropagating pump signals. The Brillouin fiber optic gyroscope of the present invention also provides a dynamic range of the gyroscope rotation rate that is twice the dynamic range of existing gyroscopes.

Abstract: An interferometer used as a rotation sensor is constructed using a strand of optical fiber, a portion of which is formed into a sensing loop. A pair of light waves are caused to counterpropagate in the sensing loop and are combined to form an optical output signal that has an intensity that varies in accordance with the difference in the phases of the two counterpropagating light waves. A phase modulator is positioned on the optical fiber in the sensing loop at a location such that the two counterpropagating light waves are modulated approximately 180 degrees out of phase. The time-varying phase modulation causes a time-varying phase difference that is combined with a rotationally-induced Sagnac effect phase to provide a total phase difference that is detected by a photodetector. The photodetector provides an electrical output signal this is processed to determine the Sagnac phase difference. The rotation rate is then calculated from the Sagnac phase difference.

Abstract: A integrated mass memory device is formed by combining a piezoelectric bimorph cantilever (214) with a recording surface (212) having a number of storage locations to and from which digital information is transferred using a scanning tunneling microscope or an atomic force microscope mode of operation. Controls circuits (240) are provided for controlling the scanning of the recording surface (212) and for writing and reading information into and from the recording surface. An image storage system stores images captured from an optical sensor using piezoelectric bimorph cantilevers for reading and writing digital information on recording surfaces.

Abstract: An optical mode coupling apparatus includes an Erbium-doped optical waveguide in which an optical signal at a signal wavelength propagates in a first spatial propagation mode and a second spatial propagation mode of the waveguide. The optical signal propagating in the waveguide has a beat length. The coupling apparatus includes a pump source of perturbational light signal at a perturbational wavelength that propagates in the waveguide in the first spatial propagation mode. The perturbational signal has a sufficient intensity distribution in the waveguide that it causes a perturbation of the effective refractive index of the first spatial propagation mode of the waveguide in accordance with the optical Kerr effect. The perturbation of the effective refractive index of the first spatial propagation mode of the optical waveguide causes a change in the differential phase delay in the optical signal propagating in the first and second spatial propagation modes.

Abstract: A laser source comprises an optical fiber doped with a homogeneously broadened lasing medium, preferably with Erbium, pumped by a laser pump source and an intracavity acousto-optic modulator. When the acousto-optic modulator is driven by a variable frequency source, the Erbium fluorescence line emitted by the Erbium-doped optical fiber can be electronically tuned. In another embodiment, an electronic sweep waveform is used to frequency modulate the acoustic signal produced by the acousto-optic modulator. Without the low-rate frequency modulation, Erbium in a silica optical fiber is a mostly homogeneously broadened gain medium with a narrow laser linewidth. When measured on a long time scale, low-rate frequency modulation provides a broader spectral width, on the order of 19 nm, which makes such a source an ideal source for certain optical applications such as fiber optic gyroscopes.

Abstract: MOS transistors are formed in thin films of Ge/Si alloys (Ge.sub.x Si.sub.1-x). According to the process of the present invention, polycrystalline films of Ge/Si are deposited using commercially-available LPCVD equipment, which in the preferred process uses silane and germane as the sources of Ge and Si. The deposited Ge.sub.x Si.sub.1-x films are polycrystalline at temperatures for processing down to as below 400.degree. C., and the films can be doped heavily by ion implantation and annealing at temperatures as low as 600.degree. C. to give high mobility and dopant activation yielding very low resistivity. By carrying out the annealing step in the formation of the thin film transistors in the temperature range of 400.degree. to 500.degree. C., the films provide very large grain size, minimizing the impact of grain boundaries in the polycrystalline films where the thin film transistors are to be formed. As a result, thin film MOS transistors are fabricated at temperatures below 500.degree. C.

Abstract: A method is provided for determining the packing conformation of amino acid side chains on a fixed peptide backbone. Using a steric interaction potential, the side chain atoms are rotated about carbon-carbon bonds such that the side chains preferably settle in a low energy packing conformation. Rotational moves are continued according to a simulated annealing procedure until a set of low energy conformations are identified. These conformations represent the structure of the actual peptide. The method may be employed to identify the packing configuration of mutant peptides.