Patents Assigned to The Trustees of the University of Michigan
  • Methods for treating restenosis with p21
    Patent number: 6218372
    Abstract: The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G0/G1, alteration in morphology, and cell differentiation.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: April 17, 2001
    Assignee: The Trustees of the University of Michigan
    Inventors: Gary J. Nabel, Zhi-yong Yang, Elizabeth G. Nabel